Milk-Derived Proteins and Peptides in Head and Neck Carcinoma Treatment
Research investigating milk-derived proteins has brought to light the potential for their use as novel anticancer agents. This paper aims to systematically review studies examining the effectiveness of milk-derived proteins in the treatment of head and neck cancer. A systematic literature search of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/2/290 |
| _version_ | 1797482187766890496 |
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| author | Theresa Wang Xinyi Liu Yah Ying Ng Kiera Tarleton Amy Tran Thomas Tran Wen Yue Xue Paul Youssef Peiyu Yuan Daniel Zhang Rita Paolini Antonio Celentano |
| author_facet | Theresa Wang Xinyi Liu Yah Ying Ng Kiera Tarleton Amy Tran Thomas Tran Wen Yue Xue Paul Youssef Peiyu Yuan Daniel Zhang Rita Paolini Antonio Celentano |
| author_sort | Theresa Wang |
| collection | DOAJ |
| description | Research investigating milk-derived proteins has brought to light the potential for their use as novel anticancer agents. This paper aims to systematically review studies examining the effectiveness of milk-derived proteins in the treatment of head and neck cancer. A systematic literature search of Medline, Evidence-Based Medicine, and Web of Science databases including papers published from all dates was completed. Inter-rater reliability was high during the title, abstract, and full-text screening phases. Inclusion criteria, exclusion criteria, and data extraction were based on the PICOS tool and research questions. Reporting followed the Preferred Reporting Items for Systematic Review and Meta-Analysis criteria. Eligible in vitro and in vivo studies (<i>n</i> = 8/658) evaluated lactoferrin, α-lactalbumin, and its complexes, such as HAMLET, BAMLET and lactalbumin-oleic acid complexes, as well as lactoperoxidase, whey, and casein. Their effectiveness in the treatment of head and neck cancer cells lines found that these compounds can inhibit tumour growth modulate cancer gene expression, and have cytotoxic effects on cancer cells. However, the exact mechanisms by which these effects are achieved are not well understood. Systematically designed, large, optimally controlled, collaborative studies, both in vitro and in vivo, will be required to gain a better understanding of their potential role in the treatment of head and neck cancer. |
| first_indexed | 2024-03-09T22:29:37Z |
| format | Article |
| id | doaj.art-22305186e1694d78be7cbebdd17bb967 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T22:29:37Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-22305186e1694d78be7cbebdd17bb9672023-11-23T18:59:31ZengMDPI AGBiomolecules2218-273X2022-02-0112229010.3390/biom12020290Milk-Derived Proteins and Peptides in Head and Neck Carcinoma TreatmentTheresa Wang0Xinyi Liu1Yah Ying Ng2Kiera Tarleton3Amy Tran4Thomas Tran5Wen Yue Xue6Paul Youssef7Peiyu Yuan8Daniel Zhang9Rita Paolini10Antonio Celentano11Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, AustraliaMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, AustraliaMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, AustraliaMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, AustraliaMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, AustraliaMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, AustraliaMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, AustraliaMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, AustraliaMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, AustraliaMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, AustraliaMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, AustraliaMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, AustraliaResearch investigating milk-derived proteins has brought to light the potential for their use as novel anticancer agents. This paper aims to systematically review studies examining the effectiveness of milk-derived proteins in the treatment of head and neck cancer. A systematic literature search of Medline, Evidence-Based Medicine, and Web of Science databases including papers published from all dates was completed. Inter-rater reliability was high during the title, abstract, and full-text screening phases. Inclusion criteria, exclusion criteria, and data extraction were based on the PICOS tool and research questions. Reporting followed the Preferred Reporting Items for Systematic Review and Meta-Analysis criteria. Eligible in vitro and in vivo studies (<i>n</i> = 8/658) evaluated lactoferrin, α-lactalbumin, and its complexes, such as HAMLET, BAMLET and lactalbumin-oleic acid complexes, as well as lactoperoxidase, whey, and casein. Their effectiveness in the treatment of head and neck cancer cells lines found that these compounds can inhibit tumour growth modulate cancer gene expression, and have cytotoxic effects on cancer cells. However, the exact mechanisms by which these effects are achieved are not well understood. Systematically designed, large, optimally controlled, collaborative studies, both in vitro and in vivo, will be required to gain a better understanding of their potential role in the treatment of head and neck cancer.https://www.mdpi.com/2218-273X/12/2/290head and neckcancertreatmentmilk-derived peptidesproteinshuman α-lactalbumin made lethal to tumour cells |
| spellingShingle | Theresa Wang Xinyi Liu Yah Ying Ng Kiera Tarleton Amy Tran Thomas Tran Wen Yue Xue Paul Youssef Peiyu Yuan Daniel Zhang Rita Paolini Antonio Celentano Milk-Derived Proteins and Peptides in Head and Neck Carcinoma Treatment Biomolecules head and neck cancer treatment milk-derived peptides proteins human α-lactalbumin made lethal to tumour cells |
| title | Milk-Derived Proteins and Peptides in Head and Neck Carcinoma Treatment |
| title_full | Milk-Derived Proteins and Peptides in Head and Neck Carcinoma Treatment |
| title_fullStr | Milk-Derived Proteins and Peptides in Head and Neck Carcinoma Treatment |
| title_full_unstemmed | Milk-Derived Proteins and Peptides in Head and Neck Carcinoma Treatment |
| title_short | Milk-Derived Proteins and Peptides in Head and Neck Carcinoma Treatment |
| title_sort | milk derived proteins and peptides in head and neck carcinoma treatment |
| topic | head and neck cancer treatment milk-derived peptides proteins human α-lactalbumin made lethal to tumour cells |
| url | https://www.mdpi.com/2218-273X/12/2/290 |
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