Cyclic Stretch Force Induces Periodontal Ligament Cells to Secrete Exosomes That Suppress IL-1β Production Through the Inhibition of the NF-κB Signaling Pathway in Macrophages

Cyclic Stretch Force Induces Periodontal Ligament Cells to Secrete Exosomes That Suppress IL-1β Production Through the Inhibition of the NF-κB Signaling Pathway in Macrophages

In the oral mechanical environment, periodontal ligament cells (PDL cells) contribute to maintaining periodontal tissue homeostasis. Recent studies showed that exosomes, which are small vesicles secreted by various types of cells, play a pivotal role in cell-to-cell communication in biological proce...

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Bibliographic Details
Main Authors: Zhuyu Wang, Kentarou Maruyama, Yukihiko Sakisaka, Shigeki Suzuki, Hiroyuki Tada, Mizuki Suto, Masahiro Saito, Satoru Yamada, Eiji Nemoto
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
exosomes
cyclic stretch
NF-κB signaling
inflammasome
periodontal ligament cells
macrophages
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01310/full

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