Sdhd and SDHD/H19 knockout mice do not develop paraganglioma or pheochromocytoma.

Sdhd and SDHD/H19 knockout mice do not develop paraganglioma or pheochromocytoma.

BACKGROUND: Mitochondrial succinate dehydrogenase (SDH) is a component of both the tricarboxylic acid cycle and the electron transport chain. Mutations of SDHD, the first protein of intermediary metabolism shown to be involved in tumorigenesis, lead to the human tumors paraganglioma (PGL) and pheoch...

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Bibliographic Details
Main Authors: Jean-Pierre Bayley, Ivonne van Minderhout, Pancras C W Hogendoorn, Cees J Cornelisse, Annemieke van der Wal, Frans A Prins, Luc Teppema, Albert Dahan, Peter Devilee, Peter E M Taschner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2776493?pdf=render

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http://europepmc.org/articles/PMC2776493?pdf=render

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