Murine hyperglycemic vasculopathy and cardiomyopathy: whole-genome gene expression analysis predicts cellular targets and regulatory networks influenced by mannose binding lectin
Hyperglycemia, in the absence of type 1 or 2 diabetes, is an independent risk factor for cardiovascular disease. We have previously demonstrated a central role for mannose binding lectin (MBL)-mediated cardiac dysfunction in acute hyperglycemic mice. In this study, we applied whole genome microarray...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-02-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00015/full |
| _version_ | 1818986651525840896 |
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| author | Chenhui eZou Laura eLa Bonte Vasile ePavlov Gregory eStahl |
| author_facet | Chenhui eZou Laura eLa Bonte Vasile ePavlov Gregory eStahl |
| author_sort | Chenhui eZou |
| collection | DOAJ |
| description | Hyperglycemia, in the absence of type 1 or 2 diabetes, is an independent risk factor for cardiovascular disease. We have previously demonstrated a central role for mannose binding lectin (MBL)-mediated cardiac dysfunction in acute hyperglycemic mice. In this study, we applied whole genome microarray data analysis to investigate MBL’s role in systematic gene expression changes. The data predict possible intracellular events taking place in multiple cellular compartments such as enhanced insulin signaling pathway sensitivity, promoted mitochondrial respiratory function, improved cellular energy expenditure and protein quality control, improved cytoskeleton structure and facilitated intracellular trafficking, all of which may contribute to the organismal health of MBL null mice against acute hyperglycemia. Our data show a tight association between gene expression profile and tissue function which might be a very useful tool in predicting cellular targets and regulatory networks connected with in vivo observations, providing clues for further mechanistic studies. |
| first_indexed | 2024-12-20T18:54:11Z |
| format | Article |
| id | doaj.art-2233cac775ac4f76a12650e2325a777e |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-20T18:54:11Z |
| publishDate | 2012-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-2233cac775ac4f76a12650e2325a777e2022-12-21T19:29:33ZengFrontiers Media S.A.Frontiers in Immunology1664-32242012-02-01310.3389/fimmu.2012.0001517261Murine hyperglycemic vasculopathy and cardiomyopathy: whole-genome gene expression analysis predicts cellular targets and regulatory networks influenced by mannose binding lectinChenhui eZou0Laura eLa Bonte1Vasile ePavlov2Gregory eStahl3Brigham and Women's HospitalBrigham and Women's HospitalBrigham and Women's HospitalBrigham and Women's HospitalHyperglycemia, in the absence of type 1 or 2 diabetes, is an independent risk factor for cardiovascular disease. We have previously demonstrated a central role for mannose binding lectin (MBL)-mediated cardiac dysfunction in acute hyperglycemic mice. In this study, we applied whole genome microarray data analysis to investigate MBL’s role in systematic gene expression changes. The data predict possible intracellular events taking place in multiple cellular compartments such as enhanced insulin signaling pathway sensitivity, promoted mitochondrial respiratory function, improved cellular energy expenditure and protein quality control, improved cytoskeleton structure and facilitated intracellular trafficking, all of which may contribute to the organismal health of MBL null mice against acute hyperglycemia. Our data show a tight association between gene expression profile and tissue function which might be a very useful tool in predicting cellular targets and regulatory networks connected with in vivo observations, providing clues for further mechanistic studies.http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00015/fullHyperglycemiaMicroarraycardiomyopathycomplementmannose binding lectinvasculolpathy |
| spellingShingle | Chenhui eZou Laura eLa Bonte Vasile ePavlov Gregory eStahl Murine hyperglycemic vasculopathy and cardiomyopathy: whole-genome gene expression analysis predicts cellular targets and regulatory networks influenced by mannose binding lectin Frontiers in Immunology Hyperglycemia Microarray cardiomyopathy complement mannose binding lectin vasculolpathy |
| title | Murine hyperglycemic vasculopathy and cardiomyopathy: whole-genome gene expression analysis predicts cellular targets and regulatory networks influenced by mannose binding lectin |
| title_full | Murine hyperglycemic vasculopathy and cardiomyopathy: whole-genome gene expression analysis predicts cellular targets and regulatory networks influenced by mannose binding lectin |
| title_fullStr | Murine hyperglycemic vasculopathy and cardiomyopathy: whole-genome gene expression analysis predicts cellular targets and regulatory networks influenced by mannose binding lectin |
| title_full_unstemmed | Murine hyperglycemic vasculopathy and cardiomyopathy: whole-genome gene expression analysis predicts cellular targets and regulatory networks influenced by mannose binding lectin |
| title_short | Murine hyperglycemic vasculopathy and cardiomyopathy: whole-genome gene expression analysis predicts cellular targets and regulatory networks influenced by mannose binding lectin |
| title_sort | murine hyperglycemic vasculopathy and cardiomyopathy whole genome gene expression analysis predicts cellular targets and regulatory networks influenced by mannose binding lectin |
| topic | Hyperglycemia Microarray cardiomyopathy complement mannose binding lectin vasculolpathy |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00015/full |
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