Murine hyperglycemic vasculopathy and cardiomyopathy: whole-genome gene expression analysis predicts cellular targets and regulatory networks influenced by mannose binding lectin

Murine hyperglycemic vasculopathy and cardiomyopathy: whole-genome gene expression analysis predicts cellular targets and regulatory networks influenced by mannose binding lectin

Hyperglycemia, in the absence of type 1 or 2 diabetes, is an independent risk factor for cardiovascular disease. We have previously demonstrated a central role for mannose binding lectin (MBL)-mediated cardiac dysfunction in acute hyperglycemic mice. In this study, we applied whole genome microarray...

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Bibliographic Details
Main Authors: Chenhui eZou, Laura eLa Bonte, Vasile ePavlov, Gregory eStahl
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-02-01
Series:Frontiers in Immunology
Subjects:
Hyperglycemia
Microarray
cardiomyopathy
complement
mannose binding lectin
vasculolpathy
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00015/full

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