Acarbose glycosylation by AcbE for the production of acarstatins with enhanced α-amylase inhibitory activity

Acarbose glycosylation by AcbE for the production of acarstatins with enhanced α-amylase inhibitory activity

Acarbose is a potent glycosidase inhibitor widely used in the clinical treatment of type 2 diabetes mellitus (T2DM). Various acarbose analogs have been identified while exploring compounds with improved pharmacological properties. In this study, we found that AcbE from Actinoplanes sp. SE50/110 cata...

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Bibliographic Details
Main Authors:	Xin Zhang, Qungang Huang, Ziyue Guo, Feifei Cai, Qianjin Kang, Linquan Bai
Format:	Article
Language:	English
Published:	KeAi Communications Co., Ltd. 2024-06-01
Series:	Synthetic and Systems Biotechnology
Subjects:	Acarbose analogs α-amylase inhibitory activity Actinoplanes sp. Transglycosylase
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405805X24000401

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