The COVID-19 Pandemic Affects Male Patients With Chronic Spontaneous Urticaria More Than Female Patients
IntroductionThe COVID-19 pandemic dramatically disrupts health care for patients with chronic diseases including chronic spontaneous urticaria (CSU). As of now, it is unknown if the effects of the pandemic in CSU are different than in other chronic diseases. We also do not know, if different groups...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.722406/full |
| _version_ | 1818842658007678976 |
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| author | Huzeyfe Kulu Mustafa Atasoy Kemal Özyurt Marcus Maurer Atıl Avcı Muhammet Reşat Akkuş Ragıp Ertaş |
| author_facet | Huzeyfe Kulu Mustafa Atasoy Kemal Özyurt Marcus Maurer Atıl Avcı Muhammet Reşat Akkuş Ragıp Ertaş |
| author_sort | Huzeyfe Kulu |
| collection | DOAJ |
| description | IntroductionThe COVID-19 pandemic dramatically disrupts health care for patients with chronic diseases including chronic spontaneous urticaria (CSU). As of now, it is unknown if the effects of the pandemic in CSU are different than in other chronic diseases. We also do not know, if different groups of CSU patients, for example female and male patients, are affected differently.AimTo understand how CSU patients and subgroups are affected by the COVID-19 pandemic in their disease activity and control and treatment, using psoriasis as control.Patients and MethodsWe analyzed 399 patients (450 visits) with CSU or psoriasis assessed during August 2019, i.e. before the pandemic, or August 2020, i.e. during the pandemic, for changes in disease activity, disease control, and the treatment they used, and how these changes are linked to age, gender, and disease duration.ResultsMale but not female patients with CSU had markedly increased disease activity during the pandemic. CSU patients’ age or disease duration were not linked to changes. Male and female patients with psoriasis showed similar increases in disease activity and decreases in disease control. The rate of omalizumab treatment, during the pandemic, was unchanged in male patients and increased in female patients with CSU. The efficacy of omalizumab treatment, during the pandemic, was reduced in male patients but not female patients with CSU.ConclusionMale but not female CSU patients, during the COVID-19 pandemic, show loss of disease control linked to loss of omalizumab efficacy. The reasons for this need to be investigated. |
| first_indexed | 2024-12-19T04:45:28Z |
| format | Article |
| id | doaj.art-2235f84cafb444e08816173bda9b54e6 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-19T04:45:28Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-2235f84cafb444e08816173bda9b54e62022-12-21T20:35:29ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-10-011210.3389/fimmu.2021.722406722406The COVID-19 Pandemic Affects Male Patients With Chronic Spontaneous Urticaria More Than Female PatientsHuzeyfe Kulu0Mustafa Atasoy1Kemal Özyurt2Marcus Maurer3Atıl Avcı4Muhammet Reşat Akkuş5Ragıp Ertaş6Urticaria Center of Reference and Excellence (UCARE), Chronic Skin Diseases Unit, Department of Dermatology, Kayseri City Hospital, Kayseri, TurkeyUrticaria Center of Reference and Excellence (UCARE), Chronic Skin Diseases Unit, Department of Dermatology, Kayseri City Hospital, Kayseri, TurkeyUrticaria Center of Reference and Excellence (UCARE), Chronic Skin Diseases Unit, Department of Dermatology, Kayseri City Hospital, Kayseri, TurkeyUrticaria Center of Reference and Excellence (UCARE), Dermatological Allergology, Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, GermanyUrticaria Center of Reference and Excellence (UCARE), Chronic Skin Diseases Unit, Department of Dermatology, Kayseri City Hospital, Kayseri, TurkeyUrticaria Center of Reference and Excellence (UCARE), Chronic Skin Diseases Unit, Department of Dermatology, Kayseri City Hospital, Kayseri, TurkeyUrticaria Center of Reference and Excellence (UCARE), Chronic Skin Diseases Unit, Department of Dermatology, Kayseri City Hospital, Kayseri, TurkeyIntroductionThe COVID-19 pandemic dramatically disrupts health care for patients with chronic diseases including chronic spontaneous urticaria (CSU). As of now, it is unknown if the effects of the pandemic in CSU are different than in other chronic diseases. We also do not know, if different groups of CSU patients, for example female and male patients, are affected differently.AimTo understand how CSU patients and subgroups are affected by the COVID-19 pandemic in their disease activity and control and treatment, using psoriasis as control.Patients and MethodsWe analyzed 399 patients (450 visits) with CSU or psoriasis assessed during August 2019, i.e. before the pandemic, or August 2020, i.e. during the pandemic, for changes in disease activity, disease control, and the treatment they used, and how these changes are linked to age, gender, and disease duration.ResultsMale but not female patients with CSU had markedly increased disease activity during the pandemic. CSU patients’ age or disease duration were not linked to changes. Male and female patients with psoriasis showed similar increases in disease activity and decreases in disease control. The rate of omalizumab treatment, during the pandemic, was unchanged in male patients and increased in female patients with CSU. The efficacy of omalizumab treatment, during the pandemic, was reduced in male patients but not female patients with CSU.ConclusionMale but not female CSU patients, during the COVID-19 pandemic, show loss of disease control linked to loss of omalizumab efficacy. The reasons for this need to be investigated.https://www.frontiersin.org/articles/10.3389/fimmu.2021.722406/fullchronic spontaneous urticariachronic skin diseasesCOVID-19psoriasispandemic (COVID19) |
| spellingShingle | Huzeyfe Kulu Mustafa Atasoy Kemal Özyurt Marcus Maurer Atıl Avcı Muhammet Reşat Akkuş Ragıp Ertaş The COVID-19 Pandemic Affects Male Patients With Chronic Spontaneous Urticaria More Than Female Patients Frontiers in Immunology chronic spontaneous urticaria chronic skin diseases COVID-19 psoriasis pandemic (COVID19) |
| title | The COVID-19 Pandemic Affects Male Patients With Chronic Spontaneous Urticaria More Than Female Patients |
| title_full | The COVID-19 Pandemic Affects Male Patients With Chronic Spontaneous Urticaria More Than Female Patients |
| title_fullStr | The COVID-19 Pandemic Affects Male Patients With Chronic Spontaneous Urticaria More Than Female Patients |
| title_full_unstemmed | The COVID-19 Pandemic Affects Male Patients With Chronic Spontaneous Urticaria More Than Female Patients |
| title_short | The COVID-19 Pandemic Affects Male Patients With Chronic Spontaneous Urticaria More Than Female Patients |
| title_sort | covid 19 pandemic affects male patients with chronic spontaneous urticaria more than female patients |
| topic | chronic spontaneous urticaria chronic skin diseases COVID-19 psoriasis pandemic (COVID19) |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.722406/full |
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