Can Physical Activity Support the Endocannabinoid System in the Preventive and Therapeutic Approach to Neurological Disorders?
The worldwide prevalence of neurological and neurodegenerative disorders, such as depression or Alzheimer’s disease, has spread extensively throughout the last decades, becoming an enormous health issue. Numerous data indicate a distinct correlation between the altered endocannabinoid signaling and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/12/4221 |
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| author | Tomasz Charytoniuk Hubert Zywno Karolina Konstantynowicz-Nowicka Klaudia Berk Wiktor Bzdega Adrian Chabowski |
| author_facet | Tomasz Charytoniuk Hubert Zywno Karolina Konstantynowicz-Nowicka Klaudia Berk Wiktor Bzdega Adrian Chabowski |
| author_sort | Tomasz Charytoniuk |
| collection | DOAJ |
| description | The worldwide prevalence of neurological and neurodegenerative disorders, such as depression or Alzheimer’s disease, has spread extensively throughout the last decades, becoming an enormous health issue. Numerous data indicate a distinct correlation between the altered endocannabinoid signaling and different aspects of brain physiology, such as memory or neurogenesis. Moreover, the endocannabinoid system is widely regarded as a crucial factor in the development of neuropathologies. Thus, targeting those disorders via synthetic cannabinoids, as well as phytocannabinoids, becomes a widespread research issue. Over the last decade, the endocannabinoid system has been extensively studied for its correlation with physical activity. Recent data showed that physical activity correlates with elevated endocannabinoid serum concentrations and increased cannabinoid receptor type 1 (CB1R) expression in the brain, which results in positive neurological effects including antidepressant effect, ameliorated memory, neuroplasticity development, and reduced neuroinflammation. However, none of the prior reviews presented a comprehensive correlation between physical activity, the endocannabinoid system, and neuropathologies. Thus, our review provides a current state of knowledge of the endocannabinoid system, its action in physical activity, as well as neuropathologies and a possible correlation between all those fields. We believe that this might contribute to finding a new preventive and therapeutic approach to both neurological and neurodegenerative disorders. |
| first_indexed | 2024-03-10T19:11:50Z |
| format | Article |
| id | doaj.art-223a1a4fe8c5447a85adf7d9d1fbe42c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T19:11:50Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-223a1a4fe8c5447a85adf7d9d1fbe42c2023-11-20T03:43:45ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-06-012112422110.3390/ijms21124221Can Physical Activity Support the Endocannabinoid System in the Preventive and Therapeutic Approach to Neurological Disorders?Tomasz Charytoniuk0Hubert Zywno1Karolina Konstantynowicz-Nowicka2Klaudia Berk3Wiktor Bzdega4Adrian Chabowski5Department of Physiology, Medical University of Bialystok, 15-089 Białystok, PolandDepartment of Physiology, Medical University of Bialystok, 15-089 Białystok, PolandDepartment of Physiology, Medical University of Bialystok, 15-089 Białystok, PolandDepartment of Physiology, Medical University of Bialystok, 15-089 Białystok, PolandDepartment of Physiology, Medical University of Bialystok, 15-089 Białystok, PolandDepartment of Physiology, Medical University of Bialystok, 15-089 Białystok, PolandThe worldwide prevalence of neurological and neurodegenerative disorders, such as depression or Alzheimer’s disease, has spread extensively throughout the last decades, becoming an enormous health issue. Numerous data indicate a distinct correlation between the altered endocannabinoid signaling and different aspects of brain physiology, such as memory or neurogenesis. Moreover, the endocannabinoid system is widely regarded as a crucial factor in the development of neuropathologies. Thus, targeting those disorders via synthetic cannabinoids, as well as phytocannabinoids, becomes a widespread research issue. Over the last decade, the endocannabinoid system has been extensively studied for its correlation with physical activity. Recent data showed that physical activity correlates with elevated endocannabinoid serum concentrations and increased cannabinoid receptor type 1 (CB1R) expression in the brain, which results in positive neurological effects including antidepressant effect, ameliorated memory, neuroplasticity development, and reduced neuroinflammation. However, none of the prior reviews presented a comprehensive correlation between physical activity, the endocannabinoid system, and neuropathologies. Thus, our review provides a current state of knowledge of the endocannabinoid system, its action in physical activity, as well as neuropathologies and a possible correlation between all those fields. We believe that this might contribute to finding a new preventive and therapeutic approach to both neurological and neurodegenerative disorders.https://www.mdpi.com/1422-0067/21/12/4221endocannabinoid systemECScannabinoidsphytocannabinoidsphysical activityneurological disorders |
| spellingShingle | Tomasz Charytoniuk Hubert Zywno Karolina Konstantynowicz-Nowicka Klaudia Berk Wiktor Bzdega Adrian Chabowski Can Physical Activity Support the Endocannabinoid System in the Preventive and Therapeutic Approach to Neurological Disorders? International Journal of Molecular Sciences endocannabinoid system ECS cannabinoids phytocannabinoids physical activity neurological disorders |
| title | Can Physical Activity Support the Endocannabinoid System in the Preventive and Therapeutic Approach to Neurological Disorders? |
| title_full | Can Physical Activity Support the Endocannabinoid System in the Preventive and Therapeutic Approach to Neurological Disorders? |
| title_fullStr | Can Physical Activity Support the Endocannabinoid System in the Preventive and Therapeutic Approach to Neurological Disorders? |
| title_full_unstemmed | Can Physical Activity Support the Endocannabinoid System in the Preventive and Therapeutic Approach to Neurological Disorders? |
| title_short | Can Physical Activity Support the Endocannabinoid System in the Preventive and Therapeutic Approach to Neurological Disorders? |
| title_sort | can physical activity support the endocannabinoid system in the preventive and therapeutic approach to neurological disorders |
| topic | endocannabinoid system ECS cannabinoids phytocannabinoids physical activity neurological disorders |
| url | https://www.mdpi.com/1422-0067/21/12/4221 |
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