Hypertriglyceridemia Is Associated With White Blood Cell Count and Red Cell Distribution Width: A Gender Stratified Analysis in a Population-Based Study
Hypertriglyceridemia is a common form of dyslipidemia and is associated with several comorbidities, such as increased risk of pancreatitis and cardiovascular diseases (CVD). The white blood cell (WBC) count is a non-specific inflammatory marker associated with a wide variety of diseases such as diab...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2019-01-01
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| Series: | Acta Medica Iranica |
| Subjects: | |
| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/6501 |
| _version_ | 1819036989392945152 |
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| author | Alireza Heidari-Bakavoli Seyed Mahdi Hassanian Amir Avan Mojtaba Shafiee Afsane Bahrami Maryam Tayefi Samaneh Khakpouri Parvin Zamani Mohsen Moohebati Mahmoud Ebrahimi Farzad Rahmani Habibollah Esmaeili Mohsen Nematy Mohammad Safarian Gordon A. Ferns Mahmoud Reza Azarpajouh Mohammad Reza Parizadeh Majid Ghayour-Mobarhan |
| author_facet | Alireza Heidari-Bakavoli Seyed Mahdi Hassanian Amir Avan Mojtaba Shafiee Afsane Bahrami Maryam Tayefi Samaneh Khakpouri Parvin Zamani Mohsen Moohebati Mahmoud Ebrahimi Farzad Rahmani Habibollah Esmaeili Mohsen Nematy Mohammad Safarian Gordon A. Ferns Mahmoud Reza Azarpajouh Mohammad Reza Parizadeh Majid Ghayour-Mobarhan |
| author_sort | Alireza Heidari-Bakavoli |
| collection | DOAJ |
| description | Hypertriglyceridemia is a common form of dyslipidemia and is associated with several comorbidities, such as increased risk of pancreatitis and cardiovascular diseases (CVD). The white blood cell (WBC) count is a non-specific inflammatory marker associated with a wide variety of diseases such as diabetes, hypertension, and atherosclerotic cardiovascular disease. The objective of this study was to perform a gender-stratified examination of the association between hypertriglyceridemia and hematological parameters in a large sample of Iranian population. The triglyceride (TG) levels and hematological parameters were measured in 9,780 participants (40% males and 60% females) aged 35-65 years, enrolled in a population-based cohort (MASHAD) study in northeastern Iran. Participants were stratified into three groups based on the definition of hypertriglyceridemia: TG<150 mg/dl (n=6521), TG=150-199 mg/dl (n=1597), and TG≥200 mg/dl (n=1662). A complete blood count (CBC) was obtained for all the subjects. The mean WBC count increased with increasing severity of hypertriglyceridemia among both men and women. Participants with high and very high TG levels had significantly higher WBC count, RBC count, platelet count, hemoglobin, hematocrit, and mean corpuscular hemoglobin concentration and significantly lower RDW. After performing multivariate logistic regression, WBC count and RDW were independently related to hypertriglyceridemia. In conclusion, hypertriglyceridemia is associated with elevated WBC count which may partly explain the observed association between hypertriglyceridemia and CVD. |
| first_indexed | 2024-12-21T08:14:17Z |
| format | Article |
| id | doaj.art-223abeb2914f427d893dcd8525ae36d2 |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-12-21T08:14:17Z |
| publishDate | 2019-01-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-223abeb2914f427d893dcd8525ae36d22022-12-21T19:10:35ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942019-01-015610Hypertriglyceridemia Is Associated With White Blood Cell Count and Red Cell Distribution Width: A Gender Stratified Analysis in a Population-Based StudyAlireza Heidari-Bakavoli0Seyed Mahdi Hassanian1Amir Avan2Mojtaba Shafiee3Afsane Bahrami4Maryam Tayefi5Samaneh Khakpouri6Parvin Zamani7Mohsen Moohebati8Mahmoud Ebrahimi9Farzad Rahmani10Habibollah Esmaeili11Mohsen Nematy12Mohammad Safarian13Gordon A. Ferns14Mahmoud Reza Azarpajouh15Mohammad Reza Parizadeh16Majid Ghayour-Mobarhan17Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Medical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. AND Microanatomy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. AND Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. AND Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.Clinical Research Unit, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Medical Biotechnology, Mashhad University of Medical Sciences, Mashhad, Iran.Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Medical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. AND Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Brighton and Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK.Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Medical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. AND Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, IranMetabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. AND Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Hypertriglyceridemia is a common form of dyslipidemia and is associated with several comorbidities, such as increased risk of pancreatitis and cardiovascular diseases (CVD). The white blood cell (WBC) count is a non-specific inflammatory marker associated with a wide variety of diseases such as diabetes, hypertension, and atherosclerotic cardiovascular disease. The objective of this study was to perform a gender-stratified examination of the association between hypertriglyceridemia and hematological parameters in a large sample of Iranian population. The triglyceride (TG) levels and hematological parameters were measured in 9,780 participants (40% males and 60% females) aged 35-65 years, enrolled in a population-based cohort (MASHAD) study in northeastern Iran. Participants were stratified into three groups based on the definition of hypertriglyceridemia: TG<150 mg/dl (n=6521), TG=150-199 mg/dl (n=1597), and TG≥200 mg/dl (n=1662). A complete blood count (CBC) was obtained for all the subjects. The mean WBC count increased with increasing severity of hypertriglyceridemia among both men and women. Participants with high and very high TG levels had significantly higher WBC count, RBC count, platelet count, hemoglobin, hematocrit, and mean corpuscular hemoglobin concentration and significantly lower RDW. After performing multivariate logistic regression, WBC count and RDW were independently related to hypertriglyceridemia. In conclusion, hypertriglyceridemia is associated with elevated WBC count which may partly explain the observed association between hypertriglyceridemia and CVD.https://acta.tums.ac.ir/index.php/acta/article/view/6501HypertriglyceridemiaWhite blood cell countCardiovascular disease |
| spellingShingle | Alireza Heidari-Bakavoli Seyed Mahdi Hassanian Amir Avan Mojtaba Shafiee Afsane Bahrami Maryam Tayefi Samaneh Khakpouri Parvin Zamani Mohsen Moohebati Mahmoud Ebrahimi Farzad Rahmani Habibollah Esmaeili Mohsen Nematy Mohammad Safarian Gordon A. Ferns Mahmoud Reza Azarpajouh Mohammad Reza Parizadeh Majid Ghayour-Mobarhan Hypertriglyceridemia Is Associated With White Blood Cell Count and Red Cell Distribution Width: A Gender Stratified Analysis in a Population-Based Study Acta Medica Iranica Hypertriglyceridemia White blood cell count Cardiovascular disease |
| title | Hypertriglyceridemia Is Associated With White Blood Cell Count and Red Cell Distribution Width: A Gender Stratified Analysis in a Population-Based Study |
| title_full | Hypertriglyceridemia Is Associated With White Blood Cell Count and Red Cell Distribution Width: A Gender Stratified Analysis in a Population-Based Study |
| title_fullStr | Hypertriglyceridemia Is Associated With White Blood Cell Count and Red Cell Distribution Width: A Gender Stratified Analysis in a Population-Based Study |
| title_full_unstemmed | Hypertriglyceridemia Is Associated With White Blood Cell Count and Red Cell Distribution Width: A Gender Stratified Analysis in a Population-Based Study |
| title_short | Hypertriglyceridemia Is Associated With White Blood Cell Count and Red Cell Distribution Width: A Gender Stratified Analysis in a Population-Based Study |
| title_sort | hypertriglyceridemia is associated with white blood cell count and red cell distribution width a gender stratified analysis in a population based study |
| topic | Hypertriglyceridemia White blood cell count Cardiovascular disease |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/6501 |
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