Leiomyoma with Uncommon Localization—Incisive Papilla and Palatal Fibromucosa: A Case Report
The current paper presents a case of a 33-year-old female with an uncommon localization of a leiomyoma in the oral cavity—the anterior palatal fibromucosa and the incisive papilla. The patient referred to the Oro-Maxillo-Facial Surgery Clinic of Emergency City Hospital Timisoara, Romania, complainin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/7/1346 |
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| author | Marina Rakitovan Adrian Nicoara Raluca Maria Closca Nicolae Constantin Balica Eugen Horatiu Stefanescu Flavia Baderca |
| author_facet | Marina Rakitovan Adrian Nicoara Raluca Maria Closca Nicolae Constantin Balica Eugen Horatiu Stefanescu Flavia Baderca |
| author_sort | Marina Rakitovan |
| collection | DOAJ |
| description | The current paper presents a case of a 33-year-old female with an uncommon localization of a leiomyoma in the oral cavity—the anterior palatal fibromucosa and the incisive papilla. The patient referred to the Oro-Maxillo-Facial Surgery Clinic of Emergency City Hospital Timisoara, Romania, complaining of a slight discomfort in the act of mastication and the occurrence and persistence of a diastema between the upper central incisors, due to the presence of a nodule located in the anterior palatal mucosa, between the upper central incisors, without any changes of the subjacent bone structure in the anterior hard palate visible on a cone beam computed tomography image (CBCT). The lesion was removed using a surgical excisional biopsy and a histopathological examination was performed using morphological Hematoxylin–Eosin (HE) staining and additional immunohistochemical (IHC) reactions, in order to confirm the diagnosis. On microscopic examination, bundles of spindle cells were found with eosinophilic cytoplasm and vesicular nuclei, with finely granular chromatin. The immunohistochemical reactions were positive for smooth muscle actin (SMA) and desmin and negative for vimentin. The treatment of choice for leiomyoma of the oral cavity is surgical excision with clear margins, followed by periodical clinical monitoring. |
| first_indexed | 2024-03-11T00:50:35Z |
| format | Article |
| id | doaj.art-223c3708354044ea9a3a468e9edd4bdf |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-11T00:50:35Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-223c3708354044ea9a3a468e9edd4bdf2023-11-18T20:25:31ZengMDPI AGMedicina1010-660X1648-91442023-07-01597134610.3390/medicina59071346Leiomyoma with Uncommon Localization—Incisive Papilla and Palatal Fibromucosa: A Case ReportMarina Rakitovan0Adrian Nicoara1Raluca Maria Closca2Nicolae Constantin Balica3Eugen Horatiu Stefanescu4Flavia Baderca5Department of Microscopic Morphology, University of Medicine and Pharmacy “Victor Babes”, 300041 Timisoara, RomaniaOro-Maxillo-Facial Surgery Clinic of the Emergency City Hospital, 300062 Timisoara, RomaniaDepartment of Microscopic Morphology, University of Medicine and Pharmacy “Victor Babes”, 300041 Timisoara, RomaniaDepartment of Otorhinolaryngology, University of Medicine and Pharmacy “Victor Babes”, 300041 Timisoara, RomaniaDepartment of Otorhinolaryngology, University of Medicine and Pharmacy “Victor Babes”, 300041 Timisoara, RomaniaDepartment of Microscopic Morphology, University of Medicine and Pharmacy “Victor Babes”, 300041 Timisoara, RomaniaThe current paper presents a case of a 33-year-old female with an uncommon localization of a leiomyoma in the oral cavity—the anterior palatal fibromucosa and the incisive papilla. The patient referred to the Oro-Maxillo-Facial Surgery Clinic of Emergency City Hospital Timisoara, Romania, complaining of a slight discomfort in the act of mastication and the occurrence and persistence of a diastema between the upper central incisors, due to the presence of a nodule located in the anterior palatal mucosa, between the upper central incisors, without any changes of the subjacent bone structure in the anterior hard palate visible on a cone beam computed tomography image (CBCT). The lesion was removed using a surgical excisional biopsy and a histopathological examination was performed using morphological Hematoxylin–Eosin (HE) staining and additional immunohistochemical (IHC) reactions, in order to confirm the diagnosis. On microscopic examination, bundles of spindle cells were found with eosinophilic cytoplasm and vesicular nuclei, with finely granular chromatin. The immunohistochemical reactions were positive for smooth muscle actin (SMA) and desmin and negative for vimentin. The treatment of choice for leiomyoma of the oral cavity is surgical excision with clear margins, followed by periodical clinical monitoring.https://www.mdpi.com/1648-9144/59/7/1346oral pathologyleiomyomaincisive papillapalatal fibromucosasurgical excisionimmunohistochemical reaction |
| spellingShingle | Marina Rakitovan Adrian Nicoara Raluca Maria Closca Nicolae Constantin Balica Eugen Horatiu Stefanescu Flavia Baderca Leiomyoma with Uncommon Localization—Incisive Papilla and Palatal Fibromucosa: A Case Report Medicina oral pathology leiomyoma incisive papilla palatal fibromucosa surgical excision immunohistochemical reaction |
| title | Leiomyoma with Uncommon Localization—Incisive Papilla and Palatal Fibromucosa: A Case Report |
| title_full | Leiomyoma with Uncommon Localization—Incisive Papilla and Palatal Fibromucosa: A Case Report |
| title_fullStr | Leiomyoma with Uncommon Localization—Incisive Papilla and Palatal Fibromucosa: A Case Report |
| title_full_unstemmed | Leiomyoma with Uncommon Localization—Incisive Papilla and Palatal Fibromucosa: A Case Report |
| title_short | Leiomyoma with Uncommon Localization—Incisive Papilla and Palatal Fibromucosa: A Case Report |
| title_sort | leiomyoma with uncommon localization incisive papilla and palatal fibromucosa a case report |
| topic | oral pathology leiomyoma incisive papilla palatal fibromucosa surgical excision immunohistochemical reaction |
| url | https://www.mdpi.com/1648-9144/59/7/1346 |
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