Biological Roles and Delivery Strategies for Ions to Promote Osteogenic Induction
Bone is the most studied tissue in the field of tissue regeneration. Even though it has intrinsic capability to regenerate upon injury, several pathologies and injuries could hamper the highly orchestrated bone formation and resorption process. Bone tissue engineering seeks to mimic the extracellula...
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| Format: | Article |
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2020.614545/full |
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| author | Elia Bosch-Rué Leire Diez-Tercero Barbara Giordano-Kelhoffer Luis M. Delgado Begoña M. Bosch Mireia Hoyos-Nogués Miguel Angel Mateos-Timoneda Phong A. Tran Phong A. Tran Francisco Javier Gil Roman A. Perez |
| author_facet | Elia Bosch-Rué Leire Diez-Tercero Barbara Giordano-Kelhoffer Luis M. Delgado Begoña M. Bosch Mireia Hoyos-Nogués Miguel Angel Mateos-Timoneda Phong A. Tran Phong A. Tran Francisco Javier Gil Roman A. Perez |
| author_sort | Elia Bosch-Rué |
| collection | DOAJ |
| description | Bone is the most studied tissue in the field of tissue regeneration. Even though it has intrinsic capability to regenerate upon injury, several pathologies and injuries could hamper the highly orchestrated bone formation and resorption process. Bone tissue engineering seeks to mimic the extracellular matrix of the tissue and the different biochemical pathways that lead to successful regeneration. For many years, the use of extrinsic factors (i.e., growth factors and drugs) to modulate these biological processes have been the preferred choice in the field. Even though it has been successful in some instances, this approach presents several drawbacks, such as safety-concerns, short release profile and half-time life of the compounds. On the other hand, the use of inorganic ions has attracted significant attention due to their therapeutic effects, stability and lower biological risks. Biomaterials play a key role in such strategies where they serve as a substrate for the incorporation and release of the ions. In this review, the methodologies used to incorporate ions in biomaterials is presented, highlighting the osteogenic properties of such ions and the roles of biomaterials in controlling their release. |
| first_indexed | 2024-12-16T12:38:50Z |
| format | Article |
| id | doaj.art-223cc7aff0bd4038a9b39fb2b596a1ce |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-16T12:38:50Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-223cc7aff0bd4038a9b39fb2b596a1ce2022-12-21T22:31:28ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-01-01810.3389/fcell.2020.614545614545Biological Roles and Delivery Strategies for Ions to Promote Osteogenic InductionElia Bosch-Rué0Leire Diez-Tercero1Barbara Giordano-Kelhoffer2Luis M. Delgado3Begoña M. Bosch4Mireia Hoyos-Nogués5Miguel Angel Mateos-Timoneda6Phong A. Tran7Phong A. Tran8Francisco Javier Gil9Roman A. Perez10Bioengineering Institute of Technology, Universitat Internacional de Catalunya, Barcelona, SpainBioengineering Institute of Technology, Universitat Internacional de Catalunya, Barcelona, SpainBioengineering Institute of Technology, Universitat Internacional de Catalunya, Barcelona, SpainBioengineering Institute of Technology, Universitat Internacional de Catalunya, Barcelona, SpainBioengineering Institute of Technology, Universitat Internacional de Catalunya, Barcelona, SpainBioengineering Institute of Technology, Universitat Internacional de Catalunya, Barcelona, SpainBioengineering Institute of Technology, Universitat Internacional de Catalunya, Barcelona, SpainCentre for Biomedical Technologies, Queensland University of Technology (QUT), Brisbane, QLD, AustraliaInterface Science and Materials Engineering Group, School of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane, QLD, AustraliaBioengineering Institute of Technology, Universitat Internacional de Catalunya, Barcelona, SpainBioengineering Institute of Technology, Universitat Internacional de Catalunya, Barcelona, SpainBone is the most studied tissue in the field of tissue regeneration. Even though it has intrinsic capability to regenerate upon injury, several pathologies and injuries could hamper the highly orchestrated bone formation and resorption process. Bone tissue engineering seeks to mimic the extracellular matrix of the tissue and the different biochemical pathways that lead to successful regeneration. For many years, the use of extrinsic factors (i.e., growth factors and drugs) to modulate these biological processes have been the preferred choice in the field. Even though it has been successful in some instances, this approach presents several drawbacks, such as safety-concerns, short release profile and half-time life of the compounds. On the other hand, the use of inorganic ions has attracted significant attention due to their therapeutic effects, stability and lower biological risks. Biomaterials play a key role in such strategies where they serve as a substrate for the incorporation and release of the ions. In this review, the methodologies used to incorporate ions in biomaterials is presented, highlighting the osteogenic properties of such ions and the roles of biomaterials in controlling their release.https://www.frontiersin.org/articles/10.3389/fcell.2020.614545/fullbonescaffoldstissue engineeringbiomaterialstissue regenerationtherapeutic ions |
| spellingShingle | Elia Bosch-Rué Leire Diez-Tercero Barbara Giordano-Kelhoffer Luis M. Delgado Begoña M. Bosch Mireia Hoyos-Nogués Miguel Angel Mateos-Timoneda Phong A. Tran Phong A. Tran Francisco Javier Gil Roman A. Perez Biological Roles and Delivery Strategies for Ions to Promote Osteogenic Induction Frontiers in Cell and Developmental Biology bone scaffolds tissue engineering biomaterials tissue regeneration therapeutic ions |
| title | Biological Roles and Delivery Strategies for Ions to Promote Osteogenic Induction |
| title_full | Biological Roles and Delivery Strategies for Ions to Promote Osteogenic Induction |
| title_fullStr | Biological Roles and Delivery Strategies for Ions to Promote Osteogenic Induction |
| title_full_unstemmed | Biological Roles and Delivery Strategies for Ions to Promote Osteogenic Induction |
| title_short | Biological Roles and Delivery Strategies for Ions to Promote Osteogenic Induction |
| title_sort | biological roles and delivery strategies for ions to promote osteogenic induction |
| topic | bone scaffolds tissue engineering biomaterials tissue regeneration therapeutic ions |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2020.614545/full |
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