Delayed release dexlansoprazole in the treatment of GERD and erosive esophagitis
Eric T Wittbrodt1, Charles Baum2, David A Peura31Takeda Pharmaceuticals North America, Inc., 2Takeda Pharmaceuticals International, Inc., Deerfield, IL, USA; 3University of Virginia, School of Medicine, Charlottesville, VA, USAAbstract: Although proton pump inhibitors (PPI) have a record of remarkab...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2009-11-01
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| Series: | Clinical and Experimental Gastroenterology |
| Online Access: | http://www.dovepress.com/delayed-release-dexlansoprazole-in-the-treatment-of-gerd-and-erosive-e-a3739 |
| _version_ | 1818833206611279872 |
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| author | Eric T Wittbrodt Charles Baum David A Peura |
| author_facet | Eric T Wittbrodt Charles Baum David A Peura |
| author_sort | Eric T Wittbrodt |
| collection | DOAJ |
| description | Eric T Wittbrodt1, Charles Baum2, David A Peura31Takeda Pharmaceuticals North America, Inc., 2Takeda Pharmaceuticals International, Inc., Deerfield, IL, USA; 3University of Virginia, School of Medicine, Charlottesville, VA, USAAbstract: Although proton pump inhibitors (PPI) have a record of remarkable effectiveness and safety in the management of gastroesophageal reflux disease (GERD), several treatment challenges with PPI have emerged. Dexlansoprazole MR is the (R)-enantiomer of lansoprazole contained in a formulation that produces two distinct releases of drug and significantly extends the duration of active plasma concentrations and % time pH > 4 beyond that of conventional singlerelease PPI. Dexlansoprazole MR can be administered without regard to meals or the timing of meals in most patients. Dexlansoprazole MR 60 mg demonstrated similar efficacy for healing of erosive esophagitis at 8 weeks compared with lansoprazole 30 mg, and dexlansoprazole MR 30 mg was superior to placebo for maintenance of healed erosive esophagitis at 6 months with 99% of nights and 96% of days heartburn-free over 6 months in patients taking dexlansoprazole MR 30 mg. Superior relief of heartburn occurred in patients taking dexlansoprazole MR 30 mg (55% heartburn-free 24-hour periods) vs placebo (14%) for symptomatic nonerosive GERD. The safety profile of dexlansoprazole MR is similar to that of lansoprazole. The extended pharmacodynamic effects, added convenience, and efficacy and safety of dexlansoprazole MR offer a novel approach to gastric pH control in patients with acid-related disorders.Keywords: dexlansoprazole MR, gastroesophageal reflux disease, GERD, erosive esophagitis, TAK-390MR |
| first_indexed | 2024-12-19T02:15:14Z |
| format | Article |
| id | doaj.art-223da77930a54e5c807285a74baa53c4 |
| institution | Directory Open Access Journal |
| issn | 1178-7023 |
| language | English |
| last_indexed | 2024-12-19T02:15:14Z |
| publishDate | 2009-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical and Experimental Gastroenterology |
| spelling | doaj.art-223da77930a54e5c807285a74baa53c42022-12-21T20:40:26ZengDove Medical PressClinical and Experimental Gastroenterology1178-70232009-11-012009default117128Delayed release dexlansoprazole in the treatment of GERD and erosive esophagitisEric T WittbrodtCharles BaumDavid A PeuraEric T Wittbrodt1, Charles Baum2, David A Peura31Takeda Pharmaceuticals North America, Inc., 2Takeda Pharmaceuticals International, Inc., Deerfield, IL, USA; 3University of Virginia, School of Medicine, Charlottesville, VA, USAAbstract: Although proton pump inhibitors (PPI) have a record of remarkable effectiveness and safety in the management of gastroesophageal reflux disease (GERD), several treatment challenges with PPI have emerged. Dexlansoprazole MR is the (R)-enantiomer of lansoprazole contained in a formulation that produces two distinct releases of drug and significantly extends the duration of active plasma concentrations and % time pH > 4 beyond that of conventional singlerelease PPI. Dexlansoprazole MR can be administered without regard to meals or the timing of meals in most patients. Dexlansoprazole MR 60 mg demonstrated similar efficacy for healing of erosive esophagitis at 8 weeks compared with lansoprazole 30 mg, and dexlansoprazole MR 30 mg was superior to placebo for maintenance of healed erosive esophagitis at 6 months with 99% of nights and 96% of days heartburn-free over 6 months in patients taking dexlansoprazole MR 30 mg. Superior relief of heartburn occurred in patients taking dexlansoprazole MR 30 mg (55% heartburn-free 24-hour periods) vs placebo (14%) for symptomatic nonerosive GERD. The safety profile of dexlansoprazole MR is similar to that of lansoprazole. The extended pharmacodynamic effects, added convenience, and efficacy and safety of dexlansoprazole MR offer a novel approach to gastric pH control in patients with acid-related disorders.Keywords: dexlansoprazole MR, gastroesophageal reflux disease, GERD, erosive esophagitis, TAK-390MRhttp://www.dovepress.com/delayed-release-dexlansoprazole-in-the-treatment-of-gerd-and-erosive-e-a3739 |
| spellingShingle | Eric T Wittbrodt Charles Baum David A Peura Delayed release dexlansoprazole in the treatment of GERD and erosive esophagitis Clinical and Experimental Gastroenterology |
| title | Delayed release dexlansoprazole in the treatment of GERD and erosive esophagitis |
| title_full | Delayed release dexlansoprazole in the treatment of GERD and erosive esophagitis |
| title_fullStr | Delayed release dexlansoprazole in the treatment of GERD and erosive esophagitis |
| title_full_unstemmed | Delayed release dexlansoprazole in the treatment of GERD and erosive esophagitis |
| title_short | Delayed release dexlansoprazole in the treatment of GERD and erosive esophagitis |
| title_sort | delayed release dexlansoprazole in the treatment of gerd and erosive esophagitis |
| url | http://www.dovepress.com/delayed-release-dexlansoprazole-in-the-treatment-of-gerd-and-erosive-e-a3739 |
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