Insights into the Structures, Inhibitors, and Improvement Strategies of Glucose Oxidase
Glucose oxidase, which uses molecular oxygen as an electron acceptor to specifically catalyze the conversion of β-<span style="font-variant: small-caps;">d</span>-glucose to gluconic acid and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), has been consi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/17/9841 |
| _version_ | 1797495125296807936 |
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| author | Fan Wang Xiaona Chen Yonggang Wang Xing Li Minglai Wan Ge Zhang Feifan Leng Haibo Zhang |
| author_facet | Fan Wang Xiaona Chen Yonggang Wang Xing Li Minglai Wan Ge Zhang Feifan Leng Haibo Zhang |
| author_sort | Fan Wang |
| collection | DOAJ |
| description | Glucose oxidase, which uses molecular oxygen as an electron acceptor to specifically catalyze the conversion of β-<span style="font-variant: small-caps;">d</span>-glucose to gluconic acid and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), has been considered an important enzyme in increasing environmental sustainability and food security. However, achieving the high yield, low price and high activity required for commercial viability remains challenging. In this review, we first present a brief introduction, looking at the sources, characteristics, catalytic process, and applications of glucose oxidase. Then, the predictive structures of glucose oxidase from two different sources are comparatively discussed. We summarize the inhibitors of glucose oxidase. Finally, we highlight how the production of glucose oxidase can be improved by optimizing the culture conditions and microbial metabolic engineering. |
| first_indexed | 2024-03-10T01:43:58Z |
| format | Article |
| id | doaj.art-22433c20b6564085a6f016a7a5f2ec89 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T01:43:58Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-22433c20b6564085a6f016a7a5f2ec892023-11-23T13:18:04ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-08-012317984110.3390/ijms23179841Insights into the Structures, Inhibitors, and Improvement Strategies of Glucose OxidaseFan Wang0Xiaona Chen1Yonggang Wang2Xing Li3Minglai Wan4Ge Zhang5Feifan Leng6Haibo Zhang7Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, ChinaQingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, ChinaSchool of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, ChinaQingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, ChinaQingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, ChinaQingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, ChinaSchool of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, ChinaQingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, ChinaGlucose oxidase, which uses molecular oxygen as an electron acceptor to specifically catalyze the conversion of β-<span style="font-variant: small-caps;">d</span>-glucose to gluconic acid and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), has been considered an important enzyme in increasing environmental sustainability and food security. However, achieving the high yield, low price and high activity required for commercial viability remains challenging. In this review, we first present a brief introduction, looking at the sources, characteristics, catalytic process, and applications of glucose oxidase. Then, the predictive structures of glucose oxidase from two different sources are comparatively discussed. We summarize the inhibitors of glucose oxidase. Finally, we highlight how the production of glucose oxidase can be improved by optimizing the culture conditions and microbial metabolic engineering.https://www.mdpi.com/1422-0067/23/17/9841glucose oxidasestructuresinhibitorsyield improvement |
| spellingShingle | Fan Wang Xiaona Chen Yonggang Wang Xing Li Minglai Wan Ge Zhang Feifan Leng Haibo Zhang Insights into the Structures, Inhibitors, and Improvement Strategies of Glucose Oxidase International Journal of Molecular Sciences glucose oxidase structures inhibitors yield improvement |
| title | Insights into the Structures, Inhibitors, and Improvement Strategies of Glucose Oxidase |
| title_full | Insights into the Structures, Inhibitors, and Improvement Strategies of Glucose Oxidase |
| title_fullStr | Insights into the Structures, Inhibitors, and Improvement Strategies of Glucose Oxidase |
| title_full_unstemmed | Insights into the Structures, Inhibitors, and Improvement Strategies of Glucose Oxidase |
| title_short | Insights into the Structures, Inhibitors, and Improvement Strategies of Glucose Oxidase |
| title_sort | insights into the structures inhibitors and improvement strategies of glucose oxidase |
| topic | glucose oxidase structures inhibitors yield improvement |
| url | https://www.mdpi.com/1422-0067/23/17/9841 |
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