Repeated Measurements of Cardiac Troponin T and N-Terminal Pro-B-Type Natriuretic Peptide to Assess Long-Term Mortality Risk in Subjects with Osteoarthritis
Osteoarthritis (OA) is associated with higher cardiovascular mortality risk. High-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are well-characterized prognostic cardiac markers. We aimed to describe the changes in biomarkers measured one year apa...
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MDPI AG
2021-02-01
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| Online Access: | https://www.mdpi.com/2218-273X/11/2/230 |
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| author | Martin Rehm Gisela Büchele Rolf Erwin Brenner Klaus-Peter Günther Hermann Brenner Wolfgang Koenig Dietrich Rothenbacher |
| author_facet | Martin Rehm Gisela Büchele Rolf Erwin Brenner Klaus-Peter Günther Hermann Brenner Wolfgang Koenig Dietrich Rothenbacher |
| author_sort | Martin Rehm |
| collection | DOAJ |
| description | Osteoarthritis (OA) is associated with higher cardiovascular mortality risk. High-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are well-characterized prognostic cardiac markers. We aimed to describe the changes in biomarkers measured one year apart in a cohort of 347 subjects with OA who underwent hip or knee replacement surgery in 1995/1996 and to analyze the prognostic value of repeated measurements for long-term mortality. During a median follow-up of 19 years, 209 (60.2%) subjects died. Substantial changes in cardiac biomarkers, especially for NT-proBNP, and an independent prognostic value of NT-proBNP for long-term mortality were found for both baseline measurement concentration (hazard ratio (HR) 1.32, 95% confidence interval (CI) (1.13–1.55)) and follow-up measurement concentration (HR 1.39, 95% CI 1.18–1.64) (all HR per standard deviation increase after natural log-transformation). Baseline concentrations were correlated with follow-up concentrations of NT-proBNP and no longer showed prognostic value when included simultaneously in a single model (HR 1.08, 95% CI 0.86–1.37), whereas the estimate for the one-year measurement remained robust (HR 1.31, 95% CI 1.04–1.66). Therefore, no significant additional benefit of repeated NT-proBNP measurements was found in this cohort, facilitating the use of a single NT-proBNP measurement as a stable prognostic marker. |
| first_indexed | 2024-03-09T05:26:59Z |
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| language | English |
| last_indexed | 2024-03-09T05:26:59Z |
| publishDate | 2021-02-01 |
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| series | Biomolecules |
| spelling | doaj.art-2245bd41f81f4ab2a626794eab08e06a2023-12-03T12:35:28ZengMDPI AGBiomolecules2218-273X2021-02-0111223010.3390/biom11020230Repeated Measurements of Cardiac Troponin T and N-Terminal Pro-B-Type Natriuretic Peptide to Assess Long-Term Mortality Risk in Subjects with OsteoarthritisMartin Rehm0Gisela Büchele1Rolf Erwin Brenner2Klaus-Peter Günther3Hermann Brenner4Wolfgang Koenig5Dietrich Rothenbacher6Institute of Epidemiology and Medical Biometry, Ulm University, 89081 Ulm, GermanyInstitute of Epidemiology and Medical Biometry, Ulm University, 89081 Ulm, GermanyDivision for Biochemistry of Joint and Connective Tissue Diseases, Department of Orthopedics, Ulm University, 89081 Ulm, GermanyUniversity Center of Orthopedic and Trauma Surgery, Technical University of Dresden, 01307 Dresden, GermanyDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, GermanyInstitute of Epidemiology and Medical Biometry, Ulm University, 89081 Ulm, GermanyInstitute of Epidemiology and Medical Biometry, Ulm University, 89081 Ulm, GermanyOsteoarthritis (OA) is associated with higher cardiovascular mortality risk. High-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are well-characterized prognostic cardiac markers. We aimed to describe the changes in biomarkers measured one year apart in a cohort of 347 subjects with OA who underwent hip or knee replacement surgery in 1995/1996 and to analyze the prognostic value of repeated measurements for long-term mortality. During a median follow-up of 19 years, 209 (60.2%) subjects died. Substantial changes in cardiac biomarkers, especially for NT-proBNP, and an independent prognostic value of NT-proBNP for long-term mortality were found for both baseline measurement concentration (hazard ratio (HR) 1.32, 95% confidence interval (CI) (1.13–1.55)) and follow-up measurement concentration (HR 1.39, 95% CI 1.18–1.64) (all HR per standard deviation increase after natural log-transformation). Baseline concentrations were correlated with follow-up concentrations of NT-proBNP and no longer showed prognostic value when included simultaneously in a single model (HR 1.08, 95% CI 0.86–1.37), whereas the estimate for the one-year measurement remained robust (HR 1.31, 95% CI 1.04–1.66). Therefore, no significant additional benefit of repeated NT-proBNP measurements was found in this cohort, facilitating the use of a single NT-proBNP measurement as a stable prognostic marker.https://www.mdpi.com/2218-273X/11/2/230high-sensitivity cardiac troponin T (hs-cTnT)N-terminal pro-B-type natriuretic peptide (NT-proBNP)repeated measurementscohort studyosteoarthritismortality |
| spellingShingle | Martin Rehm Gisela Büchele Rolf Erwin Brenner Klaus-Peter Günther Hermann Brenner Wolfgang Koenig Dietrich Rothenbacher Repeated Measurements of Cardiac Troponin T and N-Terminal Pro-B-Type Natriuretic Peptide to Assess Long-Term Mortality Risk in Subjects with Osteoarthritis Biomolecules high-sensitivity cardiac troponin T (hs-cTnT) N-terminal pro-B-type natriuretic peptide (NT-proBNP) repeated measurements cohort study osteoarthritis mortality |
| title | Repeated Measurements of Cardiac Troponin T and N-Terminal Pro-B-Type Natriuretic Peptide to Assess Long-Term Mortality Risk in Subjects with Osteoarthritis |
| title_full | Repeated Measurements of Cardiac Troponin T and N-Terminal Pro-B-Type Natriuretic Peptide to Assess Long-Term Mortality Risk in Subjects with Osteoarthritis |
| title_fullStr | Repeated Measurements of Cardiac Troponin T and N-Terminal Pro-B-Type Natriuretic Peptide to Assess Long-Term Mortality Risk in Subjects with Osteoarthritis |
| title_full_unstemmed | Repeated Measurements of Cardiac Troponin T and N-Terminal Pro-B-Type Natriuretic Peptide to Assess Long-Term Mortality Risk in Subjects with Osteoarthritis |
| title_short | Repeated Measurements of Cardiac Troponin T and N-Terminal Pro-B-Type Natriuretic Peptide to Assess Long-Term Mortality Risk in Subjects with Osteoarthritis |
| title_sort | repeated measurements of cardiac troponin t and n terminal pro b type natriuretic peptide to assess long term mortality risk in subjects with osteoarthritis |
| topic | high-sensitivity cardiac troponin T (hs-cTnT) N-terminal pro-B-type natriuretic peptide (NT-proBNP) repeated measurements cohort study osteoarthritis mortality |
| url | https://www.mdpi.com/2218-273X/11/2/230 |
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