Combination of a Sindbis-SARS-CoV-2 Spike Vaccine and αOX40 Antibody Elicits Protective Immunity Against SARS-CoV-2 Induced Disease and Potentiates Long-Term SARS-CoV-2-Specific Humoral and T-Cell Immunity

Combination of a Sindbis-SARS-CoV-2 Spike Vaccine and αOX40 Antibody Elicits Protective Immunity Against SARS-CoV-2 Induced Disease and Potentiates Long-Term SARS-CoV-2-Specific Humoral and T-Cell Immunity

The COVID-19 pandemic caused by the coronavirus SARS-CoV-2 is a major global public threat. Currently, a worldwide effort has been mounted to generate billions of effective SARS-CoV-2 vaccine doses to immunize the world’s population at record speeds. However, there is still a demand for alternative...

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Bibliographic Details
Main Authors: Antonella Scaglione, Silvana Opp, Alicia Hurtado, Ziyan Lin, Christine Pampeno, Maria G. Noval, Sara A. Thannickal, Kenneth A. Stapleford, Daniel Meruelo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
Sindbis virus vaccine
αOX40
synergistic combination SARS-CoV-2 vaccine strategy
SARS-CoV-2 immunity
alphavirus vaccine
COVID19
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.719077/full

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