Role of Dectin-1 in peripheral nerve injury
Dectin-1, a C-type lectin receptor, plays a role in nerve injury in the central nervous system. However, whether it plays a role in the peripheral nervous system is not well understood. Our study showed the expression of Dectin-1 on the membrane of macrophages. We also used a sciatic nerve crushing...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2022.810647/full |
| _version_ | 1818041405124116480 |
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| author | Angela Yu-Huey Hsu Angela Yu-Huey Hsu Sung-Tsang Hsieh Sung-Tsang Hsieh Sung-Tsang Hsieh Sung-Tsang Hsieh |
| author_facet | Angela Yu-Huey Hsu Angela Yu-Huey Hsu Sung-Tsang Hsieh Sung-Tsang Hsieh Sung-Tsang Hsieh Sung-Tsang Hsieh |
| author_sort | Angela Yu-Huey Hsu |
| collection | DOAJ |
| description | Dectin-1, a C-type lectin receptor, plays a role in nerve injury in the central nervous system. However, whether it plays a role in the peripheral nervous system is not well understood. Our study showed the expression of Dectin-1 on the membrane of macrophages. We also used a sciatic nerve crushing injury model to demonstrate that there was a delay in nerve degeneration-related processes such as breakdown of injured myelinated nerve fibers and formation of myelin ovoid in groups injected with whole glucan particle soluble (WGPS), a Dectin-1 antagonist. There were also fewer intraneural blood vessels in the Dectin-1 antagonist treated group. Our study suggested inhibiting Dectin-1 delayed debris clearance, nerve degeneration, and angiogenesis after peripheral nerve injury. |
| first_indexed | 2024-12-10T08:29:54Z |
| format | Article |
| id | doaj.art-2249a904255d45b18a82f49d06fbea44 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-10T08:29:54Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-2249a904255d45b18a82f49d06fbea442022-12-22T01:56:07ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022022-07-011610.3389/fncel.2022.810647810647Role of Dectin-1 in peripheral nerve injuryAngela Yu-Huey Hsu0Angela Yu-Huey Hsu1Sung-Tsang Hsieh2Sung-Tsang Hsieh3Sung-Tsang Hsieh4Sung-Tsang Hsieh5School of Medicine, National Taiwan University, Taipei, TaiwanDepartment of Medical Education, National Taiwan University Hospital, Taipei, TaiwanDepartment of Anatomy and Cell Biology, National Taiwan University, Taipei, TaiwanGraduate Institute of Brain and Mind Sciences, National Taiwan University, Taipei, TaiwanCenter of Precision Medicine, National Taiwan University Hospital, Taipei, TaiwanDepartment of Neurology, National Taiwan University Hospital, Taipei, TaiwanDectin-1, a C-type lectin receptor, plays a role in nerve injury in the central nervous system. However, whether it plays a role in the peripheral nervous system is not well understood. Our study showed the expression of Dectin-1 on the membrane of macrophages. We also used a sciatic nerve crushing injury model to demonstrate that there was a delay in nerve degeneration-related processes such as breakdown of injured myelinated nerve fibers and formation of myelin ovoid in groups injected with whole glucan particle soluble (WGPS), a Dectin-1 antagonist. There were also fewer intraneural blood vessels in the Dectin-1 antagonist treated group. Our study suggested inhibiting Dectin-1 delayed debris clearance, nerve degeneration, and angiogenesis after peripheral nerve injury.https://www.frontiersin.org/articles/10.3389/fncel.2022.810647/fullWallerian degenerationmacrophageperipheral nerve injuryperipheral nerve regenerationDectin-1 |
| spellingShingle | Angela Yu-Huey Hsu Angela Yu-Huey Hsu Sung-Tsang Hsieh Sung-Tsang Hsieh Sung-Tsang Hsieh Sung-Tsang Hsieh Role of Dectin-1 in peripheral nerve injury Frontiers in Cellular Neuroscience Wallerian degeneration macrophage peripheral nerve injury peripheral nerve regeneration Dectin-1 |
| title | Role of Dectin-1 in peripheral nerve injury |
| title_full | Role of Dectin-1 in peripheral nerve injury |
| title_fullStr | Role of Dectin-1 in peripheral nerve injury |
| title_full_unstemmed | Role of Dectin-1 in peripheral nerve injury |
| title_short | Role of Dectin-1 in peripheral nerve injury |
| title_sort | role of dectin 1 in peripheral nerve injury |
| topic | Wallerian degeneration macrophage peripheral nerve injury peripheral nerve regeneration Dectin-1 |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2022.810647/full |
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