Multimorbidity of Allergic Conditions in Urban Citizens of Southern China: A Real-World Cross-Sectional Study
Background: Extensive knowledge of allergic multimorbidities is required to improve the management of allergic diseases with the industrialization of China. However, the demography and allergen distribution patterns of allergic multimorbidities in China remain unclear, despite the increasing prevale...
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MDPI AG
2023-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/6/2226 |
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| author | Ya-Ting Li Ming-Hui Hou Ya-Xin Lu Pei-Ran Chen Zhen-Yuan Dai Li-Fen Yang Ping-Ping Zhang Guo-Wei Xiong Zi-Feng Liu Qi-Lin Zhou Jing Su Yun Cheng Yu-Qi Zhou Jin Tao Xue-Kun Huang Min Dai Kun Zhang Min Zhou Qin-Tai Yang Pei-Ying Feng Zhuang-Gui Chen |
| author_facet | Ya-Ting Li Ming-Hui Hou Ya-Xin Lu Pei-Ran Chen Zhen-Yuan Dai Li-Fen Yang Ping-Ping Zhang Guo-Wei Xiong Zi-Feng Liu Qi-Lin Zhou Jing Su Yun Cheng Yu-Qi Zhou Jin Tao Xue-Kun Huang Min Dai Kun Zhang Min Zhou Qin-Tai Yang Pei-Ying Feng Zhuang-Gui Chen |
| author_sort | Ya-Ting Li |
| collection | DOAJ |
| description | Background: Extensive knowledge of allergic multimorbidities is required to improve the management of allergic diseases with the industrialization of China. However, the demography and allergen distribution patterns of allergic multimorbidities in China remain unclear, despite the increasing prevalence of allergies. Methods: This was a real-world, cross-sectional study of 1273 outpatients diagnosed with one or more allergic diseases in Guangzhou, the most populated city of southern China, with leading industrial and commercial centers, between April 2021 and March 2022. Seven allergic diseases (allergic rhinitis (AR), asthma (AS)/cough variant asthma (CVA), atopic dermatitis (AD)/eczema, food allergy (FA), allergic conjunctivitis (AC), drug allergy (DA), and anaphylaxis) were assessed. Positive rates of sensitization to different allergens were measured using an allergen detection system of the UniCAP (Pharmacia Diagnostics, Sweden) instrument platform to compare the groups of allergic multimorbidities against a single entity. Results: There were 659 (51.8%) males and 614 (48.2%) females aged from 4 months to 74 years included in the analysis. The study participants who were diagnosed with allergic diseases had an average of 1.6 diagnoses. Overall, 46.5% (592 of 1273) of the patients had more than one allergic condition, and allergic rhinitis was the most common type of multimorbidity. Women were more likely to suffer from an allergic disease alone, whereas allergic multimorbidities were more likely to be diagnosed in men (<i>p</i> = 0.005). In addition, allergic multimorbidities were common in all age groups, with an incidence ranging from 37.1% to 57.4%, in which children and adolescents were more frequently diagnosed with allergic multimorbidities than adults (18–60 years old) (all <i>p</i> < 0.05). Allergic multimorbidity was observed throughout the year. A difference in the positive rate of allergens sensitization and total immunoglobulin E (tIgE) levels between different allergic multimorbidities was observed. Conclusions: Allergic multimorbidities were very commonly found in nearly half of all patients with allergies. The proportion of allergic multimorbidities varied with the type of disease, sex, age, and allergen distribution pattern. These findings may help clinicians to develop “One health” strategies for the clinical management of allergic diseases. |
| first_indexed | 2024-03-11T06:21:50Z |
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| language | English |
| last_indexed | 2024-03-11T06:21:50Z |
| publishDate | 2023-03-01 |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-224ad9a59ca74678966e7894fc02a99d2023-11-17T11:49:52ZengMDPI AGJournal of Clinical Medicine2077-03832023-03-01126222610.3390/jcm12062226Multimorbidity of Allergic Conditions in Urban Citizens of Southern China: A Real-World Cross-Sectional StudyYa-Ting Li0Ming-Hui Hou1Ya-Xin Lu2Pei-Ran Chen3Zhen-Yuan Dai4Li-Fen Yang5Ping-Ping Zhang6Guo-Wei Xiong7Zi-Feng Liu8Qi-Lin Zhou9Jing Su10Yun Cheng11Yu-Qi Zhou12Jin Tao13Xue-Kun Huang14Min Dai15Kun Zhang16Min Zhou17Qin-Tai Yang18Pei-Ying Feng19Zhuang-Gui Chen20Department of Allergy, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaDepartment of Pediatrics, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaDepartment of Clinical Data Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaDepartment of Dermatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaDepartment of Pediatrics, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaDepartment of Pediatrics, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaDepartment of Allergy, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaDepartment of Allergy, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaDepartment of Clinical Data Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaDepartment of Allergy, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaDepartment of Allergy, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaDepartment of Allergy, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaDepartment of Allergy, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaDepartment of Allergy, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaDepartment of Allergy, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaDepartment of Allergy, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaDepartment of Allergy, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaDepartment of Allergy, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaDepartment of Allergy, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaDepartment of Allergy, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaDepartment of Allergy, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, ChinaBackground: Extensive knowledge of allergic multimorbidities is required to improve the management of allergic diseases with the industrialization of China. However, the demography and allergen distribution patterns of allergic multimorbidities in China remain unclear, despite the increasing prevalence of allergies. Methods: This was a real-world, cross-sectional study of 1273 outpatients diagnosed with one or more allergic diseases in Guangzhou, the most populated city of southern China, with leading industrial and commercial centers, between April 2021 and March 2022. Seven allergic diseases (allergic rhinitis (AR), asthma (AS)/cough variant asthma (CVA), atopic dermatitis (AD)/eczema, food allergy (FA), allergic conjunctivitis (AC), drug allergy (DA), and anaphylaxis) were assessed. Positive rates of sensitization to different allergens were measured using an allergen detection system of the UniCAP (Pharmacia Diagnostics, Sweden) instrument platform to compare the groups of allergic multimorbidities against a single entity. Results: There were 659 (51.8%) males and 614 (48.2%) females aged from 4 months to 74 years included in the analysis. The study participants who were diagnosed with allergic diseases had an average of 1.6 diagnoses. Overall, 46.5% (592 of 1273) of the patients had more than one allergic condition, and allergic rhinitis was the most common type of multimorbidity. Women were more likely to suffer from an allergic disease alone, whereas allergic multimorbidities were more likely to be diagnosed in men (<i>p</i> = 0.005). In addition, allergic multimorbidities were common in all age groups, with an incidence ranging from 37.1% to 57.4%, in which children and adolescents were more frequently diagnosed with allergic multimorbidities than adults (18–60 years old) (all <i>p</i> < 0.05). Allergic multimorbidity was observed throughout the year. A difference in the positive rate of allergens sensitization and total immunoglobulin E (tIgE) levels between different allergic multimorbidities was observed. Conclusions: Allergic multimorbidities were very commonly found in nearly half of all patients with allergies. The proportion of allergic multimorbidities varied with the type of disease, sex, age, and allergen distribution pattern. These findings may help clinicians to develop “One health” strategies for the clinical management of allergic diseases.https://www.mdpi.com/2077-0383/12/6/2226allergic diseasemultimorbiditiesSouthern Chinaallergy management |
| spellingShingle | Ya-Ting Li Ming-Hui Hou Ya-Xin Lu Pei-Ran Chen Zhen-Yuan Dai Li-Fen Yang Ping-Ping Zhang Guo-Wei Xiong Zi-Feng Liu Qi-Lin Zhou Jing Su Yun Cheng Yu-Qi Zhou Jin Tao Xue-Kun Huang Min Dai Kun Zhang Min Zhou Qin-Tai Yang Pei-Ying Feng Zhuang-Gui Chen Multimorbidity of Allergic Conditions in Urban Citizens of Southern China: A Real-World Cross-Sectional Study Journal of Clinical Medicine allergic disease multimorbidities Southern China allergy management |
| title | Multimorbidity of Allergic Conditions in Urban Citizens of Southern China: A Real-World Cross-Sectional Study |
| title_full | Multimorbidity of Allergic Conditions in Urban Citizens of Southern China: A Real-World Cross-Sectional Study |
| title_fullStr | Multimorbidity of Allergic Conditions in Urban Citizens of Southern China: A Real-World Cross-Sectional Study |
| title_full_unstemmed | Multimorbidity of Allergic Conditions in Urban Citizens of Southern China: A Real-World Cross-Sectional Study |
| title_short | Multimorbidity of Allergic Conditions in Urban Citizens of Southern China: A Real-World Cross-Sectional Study |
| title_sort | multimorbidity of allergic conditions in urban citizens of southern china a real world cross sectional study |
| topic | allergic disease multimorbidities Southern China allergy management |
| url | https://www.mdpi.com/2077-0383/12/6/2226 |
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