Prenatal and perinatal risk factors of food allergy in Taiwanese young children
Background: In recent decades, the prevalence of food allergy (FA) in children has increased in Western countries; however, there have been only limited studies on FA, especially among young children, in Asian countries, including Taiwan. In this study, we identified prenatal and perinatal risk fact...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | World Allergy Organization Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1939455122000394 |
| _version_ | 1817970046895390720 |
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| author | Lin Ching-Wei, MD Tsai Yi-Fen, MSc Su Yu-Tsun, MD Yu Hong-Ren, MD, PhD Li Hsing-Jung, MD Hung Chih-Hsing, MD, PhD Liu Li-Fan, PhD Tsai Hui-Ju, PhD Wang Jiu-Yao, MD, DPhil |
| author_facet | Lin Ching-Wei, MD Tsai Yi-Fen, MSc Su Yu-Tsun, MD Yu Hong-Ren, MD, PhD Li Hsing-Jung, MD Hung Chih-Hsing, MD, PhD Liu Li-Fan, PhD Tsai Hui-Ju, PhD Wang Jiu-Yao, MD, DPhil |
| author_sort | Lin Ching-Wei, MD |
| collection | DOAJ |
| description | Background: In recent decades, the prevalence of food allergy (FA) in children has increased in Western countries; however, there have been only limited studies on FA, especially among young children, in Asian countries, including Taiwan. In this study, we identified prenatal and perinatal risk factors associated with FA in young children in Taiwan. Methods: For this prospective birth cohort study, we adopted the Southern Taiwan Allergy Research Alliance (STARA)-FA questionnaire to collect data related to prenatal and perinatal risk factors and self-reported allergic symptoms in children aged 1–3 years in the well-baby clinics of 4 medical centers located in 3 cities, Chia-Yi, Tainan, and Kaohsiung, Taiwan. The STARA-FA questionnaire consisted of 99 questions to investigate the association of prenatal and perinatal risk factors with FA. Results: We recruited 903 young children aged 1–3 years in Taiwan. Among those, 95 (14.7%) children had allergic reactions to foods. The most common food allergens were eggs (26/95, 27.3%), milk (22/95, 23.2%), fruits (13/95, 13.7%), and seafood (12/95, 12.6%). We also found that there were 134 (14.8%) children with eczema, 86 (9.5%) with wheezing, and 240 (26.6%) with rhinitis. Children with a personal history of eczema (adjusted odds ratio [AOR], 2.48; 95% confidence interval [CI], 1.38–4.45) and a family allergy history (AOR, 2.06; 95% CI, 1.18–3.57) had a significantly increased risk of FA. Maternal peanut consumption during pregnancy was associated with a decreased risk of FA in children (AOR, 0.57; 95% CI, 0.33–0.98). Conclusions: In this study, the prevalence of FA in a cohort of Taiwanese young children was 14.7%. Risk factors associated with FA were a personal eczema history and a family allergy history, which might serve as predictive or prevention factors for the development of FA in young children in Taiwan. |
| first_indexed | 2024-04-13T20:29:13Z |
| format | Article |
| id | doaj.art-224f7209c40a41d1a5e8edce803b67e9 |
| institution | Directory Open Access Journal |
| issn | 1939-4551 |
| language | English |
| last_indexed | 2024-04-13T20:29:13Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Allergy Organization Journal |
| spelling | doaj.art-224f7209c40a41d1a5e8edce803b67e92022-12-22T02:31:13ZengElsevierWorld Allergy Organization Journal1939-45512022-07-01157100663Prenatal and perinatal risk factors of food allergy in Taiwanese young childrenLin Ching-Wei, MD0Tsai Yi-Fen, MSc1Su Yu-Tsun, MD2Yu Hong-Ren, MD, PhD3Li Hsing-Jung, MD4Hung Chih-Hsing, MD, PhD5Liu Li-Fan, PhD6Tsai Hui-Ju, PhD7Wang Jiu-Yao, MD, DPhil8Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, TaiwanDepartment of Pediatrics, E-Da Hospital, School of Medicine for International Students, I-Shou University, Kaohsiung, TaiwanDepartment of Pediatrics, Kaohsiung Chan Gung Memorial Hospital, Kaohsiung, TaiwanDepartment of Pediatrics, St. Martin De Porres Hospital, Chia-Yi, TaiwanDepartment of Pediatrics, Kaohsiung Municipal Siaogang Hospital, Kaohsiung, TaiwanInstitute of Gerontology, College of Medicine, National Cheng Kung University, Tainan, TaiwanInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, TaiwanDepartment of Allergy and Immunology, China Medical University Children's Hospital, Taichung, Taiwan; Research Center for Allergy, Immunology, and Microbiome (A.I.M.), China Medical University Hospital, Taichung, Taiwan; Corresponding author. Jiu-Yao Wang, MD, DPhil, China Medical University Children's Hospital, No.2, Yuh-Der Road, Taichung, 404, Taiwan.Background: In recent decades, the prevalence of food allergy (FA) in children has increased in Western countries; however, there have been only limited studies on FA, especially among young children, in Asian countries, including Taiwan. In this study, we identified prenatal and perinatal risk factors associated with FA in young children in Taiwan. Methods: For this prospective birth cohort study, we adopted the Southern Taiwan Allergy Research Alliance (STARA)-FA questionnaire to collect data related to prenatal and perinatal risk factors and self-reported allergic symptoms in children aged 1–3 years in the well-baby clinics of 4 medical centers located in 3 cities, Chia-Yi, Tainan, and Kaohsiung, Taiwan. The STARA-FA questionnaire consisted of 99 questions to investigate the association of prenatal and perinatal risk factors with FA. Results: We recruited 903 young children aged 1–3 years in Taiwan. Among those, 95 (14.7%) children had allergic reactions to foods. The most common food allergens were eggs (26/95, 27.3%), milk (22/95, 23.2%), fruits (13/95, 13.7%), and seafood (12/95, 12.6%). We also found that there were 134 (14.8%) children with eczema, 86 (9.5%) with wheezing, and 240 (26.6%) with rhinitis. Children with a personal history of eczema (adjusted odds ratio [AOR], 2.48; 95% confidence interval [CI], 1.38–4.45) and a family allergy history (AOR, 2.06; 95% CI, 1.18–3.57) had a significantly increased risk of FA. Maternal peanut consumption during pregnancy was associated with a decreased risk of FA in children (AOR, 0.57; 95% CI, 0.33–0.98). Conclusions: In this study, the prevalence of FA in a cohort of Taiwanese young children was 14.7%. Risk factors associated with FA were a personal eczema history and a family allergy history, which might serve as predictive or prevention factors for the development of FA in young children in Taiwan.http://www.sciencedirect.com/science/article/pii/S1939455122000394Food allergyPrevalenceQuestionnaireRisk factorsAtopy |
| spellingShingle | Lin Ching-Wei, MD Tsai Yi-Fen, MSc Su Yu-Tsun, MD Yu Hong-Ren, MD, PhD Li Hsing-Jung, MD Hung Chih-Hsing, MD, PhD Liu Li-Fan, PhD Tsai Hui-Ju, PhD Wang Jiu-Yao, MD, DPhil Prenatal and perinatal risk factors of food allergy in Taiwanese young children World Allergy Organization Journal Food allergy Prevalence Questionnaire Risk factors Atopy |
| title | Prenatal and perinatal risk factors of food allergy in Taiwanese young children |
| title_full | Prenatal and perinatal risk factors of food allergy in Taiwanese young children |
| title_fullStr | Prenatal and perinatal risk factors of food allergy in Taiwanese young children |
| title_full_unstemmed | Prenatal and perinatal risk factors of food allergy in Taiwanese young children |
| title_short | Prenatal and perinatal risk factors of food allergy in Taiwanese young children |
| title_sort | prenatal and perinatal risk factors of food allergy in taiwanese young children |
| topic | Food allergy Prevalence Questionnaire Risk factors Atopy |
| url | http://www.sciencedirect.com/science/article/pii/S1939455122000394 |
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