A Comparative Pharmacokinetic Study by UHPLC-MS/MS of Main Active Compounds after Oral Administration of Zushima-Gancao Extract in Normal and Adjuvant-Induced Arthritis Rats

A Comparative Pharmacokinetic Study by UHPLC-MS/MS of Main Active Compounds after Oral Administration of Zushima-Gancao Extract in Normal and Adjuvant-Induced Arthritis Rats

A sensitive and rapid ultra high-performance liquid-chromatography tandem mass spectrometry (UHPLC-MS/MS) method has been applied to investigate the influence of rheumatoid arthritis (RA) on the pharmacokinetics of nine analytes (daphnetin, daphnoretin, 7-hydroxycoumarin, liquiritin, isoliquiritin,...

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Bibliographic Details
Main Authors: Jinjun Shan, Wenjuan Qian, Linxiu Peng, Lianghui Chen, An Kang, Tong Xie, Liuqing Di
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:Molecules
Subjects:
Zushima-Gancao extract
UHPLC-MS/MS
rheumatoid arthritis
pharmacokinetics
Online Access:http://www.mdpi.com/1420-3049/23/1/227

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