Terpenes with antimicrobial and antioxidant activities from Lannea humilis (Oliv.)
This aim of this study was to isolate chemical compounds with antimicrobial and antioxidant activities from Lannea humilis. Lannea humilis stem bark was extracted with hexane, ethyl acetate and methanol using the maceration method. Two compounds were isolated from the ethyl acetate extract. GCMS and...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-11-01
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| Series: | Scientific African |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468227620302908 |
| _version_ | 1829502874387742720 |
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| author | J.I. Achika R.G. Ayo J.D. Habila A.O. Oyewale |
| author_facet | J.I. Achika R.G. Ayo J.D. Habila A.O. Oyewale |
| author_sort | J.I. Achika |
| collection | DOAJ |
| description | This aim of this study was to isolate chemical compounds with antimicrobial and antioxidant activities from Lannea humilis. Lannea humilis stem bark was extracted with hexane, ethyl acetate and methanol using the maceration method. Two compounds were isolated from the ethyl acetate extract. GCMS and NMR analyses were used to elucidate the compounds as Lupeol (A1) and Campesterol (J3) which were active against Klebsiella pneumoniae, Escherichia coli, Streptococcus pyogenes, Staphylococcus aureus, Bacillus subtilis, Proteus mirabilis, and Salmonella typhi. The minimum inhibition concentration was between 3.125 and 12.5 µg/mL. A1 and J3 had antioxidant activities of 70 and 75% respectively at a concentration of 240 µg/mL. The compounds isolated had significant antimicrobial and antioxidant activities and could be useful precursors in the synthesis of drugs used in treating nausea, cough, body pains, acute dysentery, cholera and asthma. |
| first_indexed | 2024-12-16T09:46:08Z |
| format | Article |
| id | doaj.art-2255bceaf4824097ab3d43e3489b905f |
| institution | Directory Open Access Journal |
| issn | 2468-2276 |
| language | English |
| last_indexed | 2024-12-16T09:46:08Z |
| publishDate | 2020-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Scientific African |
| spelling | doaj.art-2255bceaf4824097ab3d43e3489b905f2022-12-21T22:36:09ZengElsevierScientific African2468-22762020-11-0110e00552Terpenes with antimicrobial and antioxidant activities from Lannea humilis (Oliv.)J.I. Achika0R.G. Ayo1J.D. Habila2A.O. Oyewale3Department of Chemistry, Federal University Lokoja, Kogi State, Nigeria; Department of Chemistry, Ahmadu Bello University, Zaria, Kaduna State, Nigeria; Corresponding author.Department of Chemistry, Ahmadu Bello University, Zaria, Kaduna State, NigeriaDepartment of Chemistry, Ahmadu Bello University, Zaria, Kaduna State, NigeriaDepartment of Chemistry, Ahmadu Bello University, Zaria, Kaduna State, NigeriaThis aim of this study was to isolate chemical compounds with antimicrobial and antioxidant activities from Lannea humilis. Lannea humilis stem bark was extracted with hexane, ethyl acetate and methanol using the maceration method. Two compounds were isolated from the ethyl acetate extract. GCMS and NMR analyses were used to elucidate the compounds as Lupeol (A1) and Campesterol (J3) which were active against Klebsiella pneumoniae, Escherichia coli, Streptococcus pyogenes, Staphylococcus aureus, Bacillus subtilis, Proteus mirabilis, and Salmonella typhi. The minimum inhibition concentration was between 3.125 and 12.5 µg/mL. A1 and J3 had antioxidant activities of 70 and 75% respectively at a concentration of 240 µg/mL. The compounds isolated had significant antimicrobial and antioxidant activities and could be useful precursors in the synthesis of drugs used in treating nausea, cough, body pains, acute dysentery, cholera and asthma.http://www.sciencedirect.com/science/article/pii/S2468227620302908Lannea humilis antioxidantAntimicrobialLupeolCampesterol |
| spellingShingle | J.I. Achika R.G. Ayo J.D. Habila A.O. Oyewale Terpenes with antimicrobial and antioxidant activities from Lannea humilis (Oliv.) Scientific African Lannea humilis antioxidant Antimicrobial Lupeol Campesterol |
| title | Terpenes with antimicrobial and antioxidant activities from Lannea humilis (Oliv.) |
| title_full | Terpenes with antimicrobial and antioxidant activities from Lannea humilis (Oliv.) |
| title_fullStr | Terpenes with antimicrobial and antioxidant activities from Lannea humilis (Oliv.) |
| title_full_unstemmed | Terpenes with antimicrobial and antioxidant activities from Lannea humilis (Oliv.) |
| title_short | Terpenes with antimicrobial and antioxidant activities from Lannea humilis (Oliv.) |
| title_sort | terpenes with antimicrobial and antioxidant activities from lannea humilis oliv |
| topic | Lannea humilis antioxidant Antimicrobial Lupeol Campesterol |
| url | http://www.sciencedirect.com/science/article/pii/S2468227620302908 |
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