C(60) fullerene prevents genotoxic effects of doxorubicin in human lymphocytes in vitro
The self-ordering of C60 fullerene, doxorubicin and their mixture precipitated from aqueous solutions was investigated using atomic-force microscopy. The results suggest the complexation between the two compounds. The genotoxicity of doxorubicin in complex with C60 fullerene (С60+Dox) was evaluate...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2015-02-01
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| Series: | The Ukrainian Biochemical Journal |
| Subjects: | |
| Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2015/05/Afanasieva_1_15.pdf |
| _version_ | 1797422280967454720 |
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| author | K. S. Afanasieva S. V. Prylutska A. V. Lozovik K. I. Bogutska A. V. Sivolob Yu. I. Prylutskyy U. Ritter P. Scharff |
| author_facet | K. S. Afanasieva S. V. Prylutska A. V. Lozovik K. I. Bogutska A. V. Sivolob Yu. I. Prylutskyy U. Ritter P. Scharff |
| author_sort | K. S. Afanasieva |
| collection | DOAJ |
| description | The self-ordering of C60 fullerene, doxorubicin and their mixture precipitated from aqueous solutions was investigated using atomic-force microscopy. The results suggest the complexation between the two compounds. The genotoxicity of doxorubicin in complex with C60 fullerene (С60+Dox) was evaluated in vitro with comet assay using human lymphocytes. The obtained results show that the C60 fullerene prevents the toxic effect of Dox in normal cells and, thus, С60+Dox complex might be proposed for biomedical application. |
| first_indexed | 2024-03-09T07:29:56Z |
| format | Article |
| id | doaj.art-22562c7c68264ac3af36c5336f2570d4 |
| institution | Directory Open Access Journal |
| issn | 2409-4943 2413-5003 |
| language | English |
| last_indexed | 2024-03-09T07:29:56Z |
| publishDate | 2015-02-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | The Ukrainian Biochemical Journal |
| spelling | doaj.art-22562c7c68264ac3af36c5336f2570d42023-12-03T06:27:15ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryThe Ukrainian Biochemical Journal2409-49432413-50032015-02-01871919810.15407/ubj87.01.091C(60) fullerene prevents genotoxic effects of doxorubicin in human lymphocytes in vitroK. S. Afanasieva0S. V. Prylutska1A. V. Lozovik2K. I. Bogutska3A. V. Sivolob4Yu. I. Prylutskyy5U. Ritter6P. Scharff7Taras Shevchenko National University of Kyiv, UkraineTaras Shevchenko National University of Kyiv, UkraineTaras Shevchenko National University of Kyiv, UkraineTaras Shevchenko National University of Kyiv, UkraineTaras Shevchenko National University of Kyiv, UkraineTaras Shevchenko National University of Kyiv, UkraineTechnical University of Ilmenau, Institute of Chemistry and Biotechnology, Ilmenau, GermanyTechnical University of Ilmenau, Institute of Chemistry and Biotechnology, Ilmenau, GermanyThe self-ordering of C60 fullerene, doxorubicin and their mixture precipitated from aqueous solutions was investigated using atomic-force microscopy. The results suggest the complexation between the two compounds. The genotoxicity of doxorubicin in complex with C60 fullerene (С60+Dox) was evaluated in vitro with comet assay using human lymphocytes. The obtained results show that the C60 fullerene prevents the toxic effect of Dox in normal cells and, thus, С60+Dox complex might be proposed for biomedical application.http://ukrbiochemjournal.org/wp-content/uploads/2015/05/Afanasieva_1_15.pdfhuman lymphocytesgenotoxicitydoxorubicincomet assayC60 fullerene |
| spellingShingle | K. S. Afanasieva S. V. Prylutska A. V. Lozovik K. I. Bogutska A. V. Sivolob Yu. I. Prylutskyy U. Ritter P. Scharff C(60) fullerene prevents genotoxic effects of doxorubicin in human lymphocytes in vitro The Ukrainian Biochemical Journal human lymphocytes genotoxicity doxorubicin comet assay C60 fullerene |
| title | C(60) fullerene prevents genotoxic effects of doxorubicin in human lymphocytes in vitro |
| title_full | C(60) fullerene prevents genotoxic effects of doxorubicin in human lymphocytes in vitro |
| title_fullStr | C(60) fullerene prevents genotoxic effects of doxorubicin in human lymphocytes in vitro |
| title_full_unstemmed | C(60) fullerene prevents genotoxic effects of doxorubicin in human lymphocytes in vitro |
| title_short | C(60) fullerene prevents genotoxic effects of doxorubicin in human lymphocytes in vitro |
| title_sort | c 60 fullerene prevents genotoxic effects of doxorubicin in human lymphocytes in vitro |
| topic | human lymphocytes genotoxicity doxorubicin comet assay C60 fullerene |
| url | http://ukrbiochemjournal.org/wp-content/uploads/2015/05/Afanasieva_1_15.pdf |
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