Potential Inflammatory Biomarkers for Major Depressive Disorder Related to Suicidal Behaviors: A Systematic Review
Major depressive disorder (MDD) is a highly prevalent psychiatric condition affecting an estimated 280 million individuals globally. Despite the occurrence of suicidal behaviors across various psychiatric conditions, MDD is distinctly associated with the highest risk of suicide attempts and death wi...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-09-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/18/13907 |
| _version_ | 1797579712269123584 |
|---|---|
| author | Ka Young Kim Ki Young Shin Keun-A Chang |
| author_facet | Ka Young Kim Ki Young Shin Keun-A Chang |
| author_sort | Ka Young Kim |
| collection | DOAJ |
| description | Major depressive disorder (MDD) is a highly prevalent psychiatric condition affecting an estimated 280 million individuals globally. Despite the occurrence of suicidal behaviors across various psychiatric conditions, MDD is distinctly associated with the highest risk of suicide attempts and death within this population. In this study, we focused on MDD to identify potential inflammatory biomarkers associated with suicidal risk, given the relationship between depressive states and suicidal ideation. Articles published before June 2023 were searched in PubMed, Embase, Web of Science, and the Cochrane Library to identify all relevant studies reporting blood inflammatory biomarkers in patients with MDD with suicide-related behaviors. Of 571 articles, 24 were included in this study. Overall, 43 significant biomarkers associated with MDD and suicide-related behaviors were identified. Our study provided compelling evidence of significant alterations in peripheral inflammatory factors in MDD patients with suicide-related behaviors, demonstrating the potential roles of interleukin (IL)-1β, IL-6, C-reactive protein, C-C motif chemokine ligand 2, and tumor necrosis factor-α as biomarkers. These findings underscore the intricate relationship between the inflammatory processes of these biomarkers and their interactions in MDD with suicidal risk. |
| first_indexed | 2024-03-10T22:40:01Z |
| format | Article |
| id | doaj.art-22582b1f408448a0b3314c6e5d68d0a2 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T22:40:01Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-22582b1f408448a0b3314c6e5d68d0a22023-11-19T11:04:54ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124181390710.3390/ijms241813907Potential Inflammatory Biomarkers for Major Depressive Disorder Related to Suicidal Behaviors: A Systematic ReviewKa Young Kim0Ki Young Shin1Keun-A Chang2Department of Nursing, College of Nursing, Gachon University, Incheon 21936, Republic of KoreaBio-MAX Institute, Seoul National University, Seoul 08826, Republic of KoreaNeuroscience Research Institute, Gachon University, Incheon 21565, Republic of KoreaMajor depressive disorder (MDD) is a highly prevalent psychiatric condition affecting an estimated 280 million individuals globally. Despite the occurrence of suicidal behaviors across various psychiatric conditions, MDD is distinctly associated with the highest risk of suicide attempts and death within this population. In this study, we focused on MDD to identify potential inflammatory biomarkers associated with suicidal risk, given the relationship between depressive states and suicidal ideation. Articles published before June 2023 were searched in PubMed, Embase, Web of Science, and the Cochrane Library to identify all relevant studies reporting blood inflammatory biomarkers in patients with MDD with suicide-related behaviors. Of 571 articles, 24 were included in this study. Overall, 43 significant biomarkers associated with MDD and suicide-related behaviors were identified. Our study provided compelling evidence of significant alterations in peripheral inflammatory factors in MDD patients with suicide-related behaviors, demonstrating the potential roles of interleukin (IL)-1β, IL-6, C-reactive protein, C-C motif chemokine ligand 2, and tumor necrosis factor-α as biomarkers. These findings underscore the intricate relationship between the inflammatory processes of these biomarkers and their interactions in MDD with suicidal risk.https://www.mdpi.com/1422-0067/24/18/13907major depressive disordersuicidal behaviorblood biomarkerinflammation |
| spellingShingle | Ka Young Kim Ki Young Shin Keun-A Chang Potential Inflammatory Biomarkers for Major Depressive Disorder Related to Suicidal Behaviors: A Systematic Review International Journal of Molecular Sciences major depressive disorder suicidal behavior blood biomarker inflammation |
| title | Potential Inflammatory Biomarkers for Major Depressive Disorder Related to Suicidal Behaviors: A Systematic Review |
| title_full | Potential Inflammatory Biomarkers for Major Depressive Disorder Related to Suicidal Behaviors: A Systematic Review |
| title_fullStr | Potential Inflammatory Biomarkers for Major Depressive Disorder Related to Suicidal Behaviors: A Systematic Review |
| title_full_unstemmed | Potential Inflammatory Biomarkers for Major Depressive Disorder Related to Suicidal Behaviors: A Systematic Review |
| title_short | Potential Inflammatory Biomarkers for Major Depressive Disorder Related to Suicidal Behaviors: A Systematic Review |
| title_sort | potential inflammatory biomarkers for major depressive disorder related to suicidal behaviors a systematic review |
| topic | major depressive disorder suicidal behavior blood biomarker inflammation |
| url | https://www.mdpi.com/1422-0067/24/18/13907 |
| work_keys_str_mv | AT kayoungkim potentialinflammatorybiomarkersformajordepressivedisorderrelatedtosuicidalbehaviorsasystematicreview AT kiyoungshin potentialinflammatorybiomarkersformajordepressivedisorderrelatedtosuicidalbehaviorsasystematicreview AT keunachang potentialinflammatorybiomarkersformajordepressivedisorderrelatedtosuicidalbehaviorsasystematicreview |