Smoking affects symptom improvement in schizophrenia: a prospective longitudinal study of male patients with first-episode schizophrenia
Abstract Patients with schizophrenia (SCZ) smoke up to three times more than general people. However, there are conflicting results regarding the relationship between tobacco smoke and clinical symptom severity in SCZ. The aim of this study was to assess the impact of smoking on clinical symptoms af...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-03-01
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| Series: | Schizophrenia |
| Online Access: | https://doi.org/10.1038/s41537-024-00449-1 |
| _version_ | 1797259198229118976 |
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| author | Xishu Mu Wenjing Wu Sisi Wang Xiuru Su Hengyong Guan Xiaoni Guan Xiaobing Lu Zezhi Li |
| author_facet | Xishu Mu Wenjing Wu Sisi Wang Xiuru Su Hengyong Guan Xiaoni Guan Xiaobing Lu Zezhi Li |
| author_sort | Xishu Mu |
| collection | DOAJ |
| description | Abstract Patients with schizophrenia (SCZ) smoke up to three times more than general people. However, there are conflicting results regarding the relationship between tobacco smoke and clinical symptom severity in SCZ. The aim of this study was to assess the impact of smoking on clinical symptoms after antipsychotic treatment in a 12-week cohort study after controlling for confounding factors. One hundred and forty-five male patients with drug-naïve first-episode (DNFE) SCZ received antipsychotic monotherapy for 12 weeks. Symptom severity was assessed at baseline and at week 12 by the Positive and Negative Syndrome Scale (PANSS). We found no differences in clinical symptoms among male smokers with SCZ compared with male nonsmokers. However, male smokers showed greater improvement in negative symptoms after 12 weeks of treatment, controlling for age, years of education, onset age, and baseline body mass index (BMI). Our study showed that after 12 weeks of treatment with antipsychotics, male smokers showed greater improvement in negative symptoms than male nonsmokers. |
| first_indexed | 2024-04-24T23:05:37Z |
| format | Article |
| id | doaj.art-2259989989df4c62b117e59c2cb16e49 |
| institution | Directory Open Access Journal |
| issn | 2754-6993 |
| language | English |
| last_indexed | 2024-04-24T23:05:37Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Schizophrenia |
| spelling | doaj.art-2259989989df4c62b117e59c2cb16e492024-03-17T12:29:12ZengNature PortfolioSchizophrenia2754-69932024-03-011011510.1038/s41537-024-00449-1Smoking affects symptom improvement in schizophrenia: a prospective longitudinal study of male patients with first-episode schizophreniaXishu Mu0Wenjing Wu1Sisi Wang2Xiuru Su3Hengyong Guan4Xiaoni Guan5Xiaobing Lu6Zezhi Li7Hebei Province Veterans HospitalQingdao Mental Health CenterQingdao Mental Health CenterHebei Province Veterans HospitalHebei Province Veterans HospitalPeking University HuiLongGuan Clinical Medical School, Beijing HuiLongGuan HospitalDepartment of Nutritional and Metabolic Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical UniversityDepartment of Nutritional and Metabolic Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical UniversityAbstract Patients with schizophrenia (SCZ) smoke up to three times more than general people. However, there are conflicting results regarding the relationship between tobacco smoke and clinical symptom severity in SCZ. The aim of this study was to assess the impact of smoking on clinical symptoms after antipsychotic treatment in a 12-week cohort study after controlling for confounding factors. One hundred and forty-five male patients with drug-naïve first-episode (DNFE) SCZ received antipsychotic monotherapy for 12 weeks. Symptom severity was assessed at baseline and at week 12 by the Positive and Negative Syndrome Scale (PANSS). We found no differences in clinical symptoms among male smokers with SCZ compared with male nonsmokers. However, male smokers showed greater improvement in negative symptoms after 12 weeks of treatment, controlling for age, years of education, onset age, and baseline body mass index (BMI). Our study showed that after 12 weeks of treatment with antipsychotics, male smokers showed greater improvement in negative symptoms than male nonsmokers.https://doi.org/10.1038/s41537-024-00449-1 |
| spellingShingle | Xishu Mu Wenjing Wu Sisi Wang Xiuru Su Hengyong Guan Xiaoni Guan Xiaobing Lu Zezhi Li Smoking affects symptom improvement in schizophrenia: a prospective longitudinal study of male patients with first-episode schizophrenia Schizophrenia |
| title | Smoking affects symptom improvement in schizophrenia: a prospective longitudinal study of male patients with first-episode schizophrenia |
| title_full | Smoking affects symptom improvement in schizophrenia: a prospective longitudinal study of male patients with first-episode schizophrenia |
| title_fullStr | Smoking affects symptom improvement in schizophrenia: a prospective longitudinal study of male patients with first-episode schizophrenia |
| title_full_unstemmed | Smoking affects symptom improvement in schizophrenia: a prospective longitudinal study of male patients with first-episode schizophrenia |
| title_short | Smoking affects symptom improvement in schizophrenia: a prospective longitudinal study of male patients with first-episode schizophrenia |
| title_sort | smoking affects symptom improvement in schizophrenia a prospective longitudinal study of male patients with first episode schizophrenia |
| url | https://doi.org/10.1038/s41537-024-00449-1 |
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