Furosemide-related thiamine deficiency in hospitalized hypervolemic patients with renal failure and heart failure
Background: We aimed to describe the thiamine status in hospitalized hypervolemic heart failure (HF) and/or renal failure (RF) patients treated with furosemide and to investigate whether there was a difference in furosemide-related thiamine deficiency between patients with RF and HF. Methods: Patien...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Nefrología (English Edition) |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2013251422001389 |
| _version_ | 1797808382355177472 |
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| author | Irem Bicer Oguzhan Sıtkı Dizdar Engin Dondurmacı Merve Ozcetin Rumeysa Yılmaz Kursat Gundogan Ali Ihsan Gunal |
| author_facet | Irem Bicer Oguzhan Sıtkı Dizdar Engin Dondurmacı Merve Ozcetin Rumeysa Yılmaz Kursat Gundogan Ali Ihsan Gunal |
| author_sort | Irem Bicer |
| collection | DOAJ |
| description | Background: We aimed to describe the thiamine status in hospitalized hypervolemic heart failure (HF) and/or renal failure (RF) patients treated with furosemide and to investigate whether there was a difference in furosemide-related thiamine deficiency between patients with RF and HF. Methods: Patients who were diagnosed as hypervolemia and treated with intravenous furosemide (at least 40 mg/day) were included in this prospective observational study. Whole blood thiamine concentrations were measured 3 times during hospital follow-up of patients. Results: We evaluated 61 hospitalized hypervolemic patients, of which 22 (36%) were men and 39 (64%) were women, with a mean age of 69.00 ± 10.39 (45–90) years. The baseline and post–hospital admission days 2 and 4 mean thiamine levels were 51.71 ± 20.66 ng/ml, 47.64 ± 15.43 ng/ml and 43.78 ± 16.20 ng/ml, respectively. Thiamine levels of the hypervolemic patients decreased significantly during the hospital stay while furosemide treatment was continuing (p = 0.029). There was a significant decrease in thiamine levels in patients who had HF (p = 0.026) and also, thiamine was significantly lower in HF patients who had previously used oral furosemide before hospitalization. However, these findings were not present in patients with RF. Conclusions: Thiamine substantially decreases in most hypervolemic patients receiving intravenous furosemide treatment during the hospital stay. Thiamine levels were significantly decreased with furosemide treatment in especially HF patients, but the decrease in thiamine levels did not detected at the same rate in RF patients. Diuretic-induced thiamine loss may be less likely in RF patients, probably due to a reduction in excretion. Resumen: Antecedentes: Nos propusimos describir el estado de la tiamina en pacientes hospitalizados con insuficiencia cardíaca (IC) y/o insuficiencia renal (IR) hipervolémica tratados con furosemida, e investigar si había una diferencia en la deficiencia de tiamina relacionada con la furosemida entre los pacientes con IR y con IC. Métodos: En este estudio observacional prospectivo se incluyeron pacientes con diagnóstico de hipervolemia y tratados con furosemida intravenosa (al menos 40 mg/día). Se midieron las concentraciones de tiamina en sangre total 3 veces durante el seguimiento hospitalario de los pacientes. Resultados: Se evaluaron 61 pacientes hipervolémicos hospitalizados, de los cuales 22 (36%) eran hombres y 39 (64%) eran mujeres, con una edad media de 69,00±10,39 (45-90) años. Los niveles medios de tiamina en la línea de base y tras el ingreso hospitalario en los días 2 y 4 fueron de 51,71±20,66 ng/ml, 47,64±15,43 ng/ml y 43,78±16,20 ng/ml, respectivamente. Los niveles de tiamina de los pacientes hipervolémicos hipervolemia disminuyeron significativamente durante la estancia en el hospital mientras se mantenía el tratamiento con furosemida furosemida (p = 0,029). Hubo una disminución significativa de los niveles de tiamina en los pacientes que tenían IC (p = 0,026) y también, la tiamina fue significativamente menor en los pacientes con IC que habían habían utilizado previamente furosemida oral antes de la hospitalización. Sin embargo, estos hallazgos no se presentes en los pacientes con IC. Conclusiones: La tiamina disminuye sustancialmente en la mayoría de los pacientes hipervolémicos que reciben tratamiento con furosemida intravenosa durante la estancia hospitalaria. Los niveles de tiamina se redujeron significativamente con el tratamiento con furosemida, especialmente en los pacientes con IC, pero la disminución de los niveles de tiamina no se detectó al mismo ritmo en los pacientes con IC. La pérdida de tiamina inducida por los diuréticos inducida por los diuréticos puede ser menos probable en los pacientes con insuficiencia cardiaca, probablemente debido a una reducción de la excreción. |
| first_indexed | 2024-03-13T06:36:42Z |
| format | Article |
| id | doaj.art-225b20e0ab0046caa8424b8d217bc089 |
| institution | Directory Open Access Journal |
| issn | 2013-2514 |
| language | English |
| last_indexed | 2024-03-13T06:36:42Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Nefrología (English Edition) |
| spelling | doaj.art-225b20e0ab0046caa8424b8d217bc0892023-06-09T04:27:43ZengElsevierNefrología (English Edition)2013-25142023-01-01431111119Furosemide-related thiamine deficiency in hospitalized hypervolemic patients with renal failure and heart failureIrem Bicer0Oguzhan Sıtkı Dizdar1Engin Dondurmacı2Merve Ozcetin3Rumeysa Yılmaz4Kursat Gundogan5Ali Ihsan Gunal6Department of Internal Medicine, Kayseri City Training and Research Hospital, 38010 Kayseri, TurkeyDepartment of Internal Medicine and Clinical Nutrition, Kayseri City Training and Research Hospital, 38010 Kayseri, Turkey; Corresponding author.Department of Cardiology, Kayseri City Training and Research Hospital, 38010 Kayseri, TurkeyDepartment of Internal Medicine, Kayseri City Training and Research Hospital, 38010 Kayseri, TurkeyDepartment of Internal Medicine, Kayseri City Training and Research Hospital, 38010 Kayseri, TurkeyDivision of Intensive Care and Clinical Nutrition Unit, Erciyes University Medicine School, 38039 Kayseri, TurkeyDepartment of Internal Medicine Division of Nephrology, Kayseri City Training and Research Hospital, 38010 Kayseri, TurkeyBackground: We aimed to describe the thiamine status in hospitalized hypervolemic heart failure (HF) and/or renal failure (RF) patients treated with furosemide and to investigate whether there was a difference in furosemide-related thiamine deficiency between patients with RF and HF. Methods: Patients who were diagnosed as hypervolemia and treated with intravenous furosemide (at least 40 mg/day) were included in this prospective observational study. Whole blood thiamine concentrations were measured 3 times during hospital follow-up of patients. Results: We evaluated 61 hospitalized hypervolemic patients, of which 22 (36%) were men and 39 (64%) were women, with a mean age of 69.00 ± 10.39 (45–90) years. The baseline and post–hospital admission days 2 and 4 mean thiamine levels were 51.71 ± 20.66 ng/ml, 47.64 ± 15.43 ng/ml and 43.78 ± 16.20 ng/ml, respectively. Thiamine levels of the hypervolemic patients decreased significantly during the hospital stay while furosemide treatment was continuing (p = 0.029). There was a significant decrease in thiamine levels in patients who had HF (p = 0.026) and also, thiamine was significantly lower in HF patients who had previously used oral furosemide before hospitalization. However, these findings were not present in patients with RF. Conclusions: Thiamine substantially decreases in most hypervolemic patients receiving intravenous furosemide treatment during the hospital stay. Thiamine levels were significantly decreased with furosemide treatment in especially HF patients, but the decrease in thiamine levels did not detected at the same rate in RF patients. Diuretic-induced thiamine loss may be less likely in RF patients, probably due to a reduction in excretion. Resumen: Antecedentes: Nos propusimos describir el estado de la tiamina en pacientes hospitalizados con insuficiencia cardíaca (IC) y/o insuficiencia renal (IR) hipervolémica tratados con furosemida, e investigar si había una diferencia en la deficiencia de tiamina relacionada con la furosemida entre los pacientes con IR y con IC. Métodos: En este estudio observacional prospectivo se incluyeron pacientes con diagnóstico de hipervolemia y tratados con furosemida intravenosa (al menos 40 mg/día). Se midieron las concentraciones de tiamina en sangre total 3 veces durante el seguimiento hospitalario de los pacientes. Resultados: Se evaluaron 61 pacientes hipervolémicos hospitalizados, de los cuales 22 (36%) eran hombres y 39 (64%) eran mujeres, con una edad media de 69,00±10,39 (45-90) años. Los niveles medios de tiamina en la línea de base y tras el ingreso hospitalario en los días 2 y 4 fueron de 51,71±20,66 ng/ml, 47,64±15,43 ng/ml y 43,78±16,20 ng/ml, respectivamente. Los niveles de tiamina de los pacientes hipervolémicos hipervolemia disminuyeron significativamente durante la estancia en el hospital mientras se mantenía el tratamiento con furosemida furosemida (p = 0,029). Hubo una disminución significativa de los niveles de tiamina en los pacientes que tenían IC (p = 0,026) y también, la tiamina fue significativamente menor en los pacientes con IC que habían habían utilizado previamente furosemida oral antes de la hospitalización. Sin embargo, estos hallazgos no se presentes en los pacientes con IC. Conclusiones: La tiamina disminuye sustancialmente en la mayoría de los pacientes hipervolémicos que reciben tratamiento con furosemida intravenosa durante la estancia hospitalaria. Los niveles de tiamina se redujeron significativamente con el tratamiento con furosemida, especialmente en los pacientes con IC, pero la disminución de los niveles de tiamina no se detectó al mismo ritmo en los pacientes con IC. La pérdida de tiamina inducida por los diuréticos inducida por los diuréticos puede ser menos probable en los pacientes con insuficiencia cardiaca, probablemente debido a una reducción de la excreción.http://www.sciencedirect.com/science/article/pii/S2013251422001389FurosemidaTiaminaInsuficiencia renalInsuficiencia cardíacaHipervolemia |
| spellingShingle | Irem Bicer Oguzhan Sıtkı Dizdar Engin Dondurmacı Merve Ozcetin Rumeysa Yılmaz Kursat Gundogan Ali Ihsan Gunal Furosemide-related thiamine deficiency in hospitalized hypervolemic patients with renal failure and heart failure Nefrología (English Edition) Furosemida Tiamina Insuficiencia renal Insuficiencia cardíaca Hipervolemia |
| title | Furosemide-related thiamine deficiency in hospitalized hypervolemic patients with renal failure and heart failure |
| title_full | Furosemide-related thiamine deficiency in hospitalized hypervolemic patients with renal failure and heart failure |
| title_fullStr | Furosemide-related thiamine deficiency in hospitalized hypervolemic patients with renal failure and heart failure |
| title_full_unstemmed | Furosemide-related thiamine deficiency in hospitalized hypervolemic patients with renal failure and heart failure |
| title_short | Furosemide-related thiamine deficiency in hospitalized hypervolemic patients with renal failure and heart failure |
| title_sort | furosemide related thiamine deficiency in hospitalized hypervolemic patients with renal failure and heart failure |
| topic | Furosemida Tiamina Insuficiencia renal Insuficiencia cardíaca Hipervolemia |
| url | http://www.sciencedirect.com/science/article/pii/S2013251422001389 |
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