Nitisinone-Induced Keratopathy in Alkaptonuria Disease: A Case Report and Literature Review

We report a case of nitisinone-induced keratopathy in a 52-year-old male patient with Alkaptonuria (AKU) disease in Jordan. The patient presented with slight drop of left eye vision for the last four weeks, associated with a foreign body sensation in his left eye. On examination, it was found that h...

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Main Authors: Khalid Mousa Al Zubi, Mohammed Salem Alsbou, Mahmoud Hussein Alkhasawneh, Hani Mosleh Al-Shagahin
Format: Article
Language:English
Published: JCDR Research and Publications Private Limited 2018-06-01
Series:Journal of Clinical and Diagnostic Research
Subjects:
Online Access:https://jcdr.net/articles/PDF/11629/35741_CE(RA1)_F(T)_PF1(AB_SS)_PN(SL).pdf
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author Khalid Mousa Al Zubi
Mohammed Salem Alsbou
Mahmoud Hussein Alkhasawneh
Hani Mosleh Al-Shagahin
author_facet Khalid Mousa Al Zubi
Mohammed Salem Alsbou
Mahmoud Hussein Alkhasawneh
Hani Mosleh Al-Shagahin
author_sort Khalid Mousa Al Zubi
collection DOAJ
description We report a case of nitisinone-induced keratopathy in a 52-year-old male patient with Alkaptonuria (AKU) disease in Jordan. The patient presented with slight drop of left eye vision for the last four weeks, associated with a foreign body sensation in his left eye. On examination, it was found that his left eye vision was reduced to 6/12 and there were left dendrite-like corneal opacities in the left eye. He was given 10 mg of nitisinone per day, two years before his visual complaint. Three months following discontinuation of nitisinone, his visual acuity and corneal opacities disappeared completely. This is the fifth reported case of nitisinone-induced keratopathy, due to secondary tyrosinaemia in alkaptonuria.
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spelling doaj.art-225b7fe7d7554184acf4f6fc0597eeec2022-12-22T01:59:31ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2018-06-01126ND01ND0310.7860/JCDR/2018/35741.11629Nitisinone-Induced Keratopathy in Alkaptonuria Disease: A Case Report and Literature ReviewKhalid Mousa Al Zubi0Mohammed Salem Alsbou1Mahmoud Hussein Alkhasawneh2Hani Mosleh Al-Shagahin3Assistant Professor, Special Surgery, Mutah University, Amman, Jordan.Associate Professor, Pharmacology, Mutah University, Amman, Jordan.Assistant Professor, Radiology, Mutah University, Amman, Jordan.Associate Professor, Special Surgery, Mutah University, AlKarak, Amman, Jordan.We report a case of nitisinone-induced keratopathy in a 52-year-old male patient with Alkaptonuria (AKU) disease in Jordan. The patient presented with slight drop of left eye vision for the last four weeks, associated with a foreign body sensation in his left eye. On examination, it was found that his left eye vision was reduced to 6/12 and there were left dendrite-like corneal opacities in the left eye. He was given 10 mg of nitisinone per day, two years before his visual complaint. Three months following discontinuation of nitisinone, his visual acuity and corneal opacities disappeared completely. This is the fifth reported case of nitisinone-induced keratopathy, due to secondary tyrosinaemia in alkaptonuria.https://jcdr.net/articles/PDF/11629/35741_CE(RA1)_F(T)_PF1(AB_SS)_PN(SL).pdfpseudodendritic keratitisrichner–hanhart syndrometyrosinaemia
spellingShingle Khalid Mousa Al Zubi
Mohammed Salem Alsbou
Mahmoud Hussein Alkhasawneh
Hani Mosleh Al-Shagahin
Nitisinone-Induced Keratopathy in Alkaptonuria Disease: A Case Report and Literature Review
Journal of Clinical and Diagnostic Research
pseudodendritic keratitis
richner–hanhart syndrome
tyrosinaemia
title Nitisinone-Induced Keratopathy in Alkaptonuria Disease: A Case Report and Literature Review
title_full Nitisinone-Induced Keratopathy in Alkaptonuria Disease: A Case Report and Literature Review
title_fullStr Nitisinone-Induced Keratopathy in Alkaptonuria Disease: A Case Report and Literature Review
title_full_unstemmed Nitisinone-Induced Keratopathy in Alkaptonuria Disease: A Case Report and Literature Review
title_short Nitisinone-Induced Keratopathy in Alkaptonuria Disease: A Case Report and Literature Review
title_sort nitisinone induced keratopathy in alkaptonuria disease a case report and literature review
topic pseudodendritic keratitis
richner–hanhart syndrome
tyrosinaemia
url https://jcdr.net/articles/PDF/11629/35741_CE(RA1)_F(T)_PF1(AB_SS)_PN(SL).pdf
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AT mahmoudhusseinalkhasawneh nitisinoneinducedkeratopathyinalkaptonuriadiseaseacasereportandliteraturereview
AT hanimoslehalshagahin nitisinoneinducedkeratopathyinalkaptonuriadiseaseacasereportandliteraturereview