Nitisinone-Induced Keratopathy in Alkaptonuria Disease: A Case Report and Literature Review
We report a case of nitisinone-induced keratopathy in a 52-year-old male patient with Alkaptonuria (AKU) disease in Jordan. The patient presented with slight drop of left eye vision for the last four weeks, associated with a foreign body sensation in his left eye. On examination, it was found that h...
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JCDR Research and Publications Private Limited
2018-06-01
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Series: | Journal of Clinical and Diagnostic Research |
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Online Access: | https://jcdr.net/articles/PDF/11629/35741_CE(RA1)_F(T)_PF1(AB_SS)_PN(SL).pdf |
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author | Khalid Mousa Al Zubi Mohammed Salem Alsbou Mahmoud Hussein Alkhasawneh Hani Mosleh Al-Shagahin |
author_facet | Khalid Mousa Al Zubi Mohammed Salem Alsbou Mahmoud Hussein Alkhasawneh Hani Mosleh Al-Shagahin |
author_sort | Khalid Mousa Al Zubi |
collection | DOAJ |
description | We report a case of nitisinone-induced keratopathy in a 52-year-old male patient with Alkaptonuria (AKU) disease in Jordan. The patient presented with slight drop of left eye vision for the last four weeks, associated with a foreign body sensation in his left eye. On examination, it was found that his left eye vision was reduced to 6/12 and there were left dendrite-like corneal opacities in the left eye. He was given 10 mg of nitisinone per day, two years before his visual complaint. Three months following discontinuation of nitisinone, his visual acuity and corneal opacities disappeared completely. This is the fifth reported case of nitisinone-induced keratopathy, due to secondary tyrosinaemia in alkaptonuria. |
first_indexed | 2024-12-10T06:11:58Z |
format | Article |
id | doaj.art-225b7fe7d7554184acf4f6fc0597eeec |
institution | Directory Open Access Journal |
issn | 2249-782X 0973-709X |
language | English |
last_indexed | 2024-12-10T06:11:58Z |
publishDate | 2018-06-01 |
publisher | JCDR Research and Publications Private Limited |
record_format | Article |
series | Journal of Clinical and Diagnostic Research |
spelling | doaj.art-225b7fe7d7554184acf4f6fc0597eeec2022-12-22T01:59:31ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2018-06-01126ND01ND0310.7860/JCDR/2018/35741.11629Nitisinone-Induced Keratopathy in Alkaptonuria Disease: A Case Report and Literature ReviewKhalid Mousa Al Zubi0Mohammed Salem Alsbou1Mahmoud Hussein Alkhasawneh2Hani Mosleh Al-Shagahin3Assistant Professor, Special Surgery, Mutah University, Amman, Jordan.Associate Professor, Pharmacology, Mutah University, Amman, Jordan.Assistant Professor, Radiology, Mutah University, Amman, Jordan.Associate Professor, Special Surgery, Mutah University, AlKarak, Amman, Jordan.We report a case of nitisinone-induced keratopathy in a 52-year-old male patient with Alkaptonuria (AKU) disease in Jordan. The patient presented with slight drop of left eye vision for the last four weeks, associated with a foreign body sensation in his left eye. On examination, it was found that his left eye vision was reduced to 6/12 and there were left dendrite-like corneal opacities in the left eye. He was given 10 mg of nitisinone per day, two years before his visual complaint. Three months following discontinuation of nitisinone, his visual acuity and corneal opacities disappeared completely. This is the fifth reported case of nitisinone-induced keratopathy, due to secondary tyrosinaemia in alkaptonuria.https://jcdr.net/articles/PDF/11629/35741_CE(RA1)_F(T)_PF1(AB_SS)_PN(SL).pdfpseudodendritic keratitisrichner–hanhart syndrometyrosinaemia |
spellingShingle | Khalid Mousa Al Zubi Mohammed Salem Alsbou Mahmoud Hussein Alkhasawneh Hani Mosleh Al-Shagahin Nitisinone-Induced Keratopathy in Alkaptonuria Disease: A Case Report and Literature Review Journal of Clinical and Diagnostic Research pseudodendritic keratitis richner–hanhart syndrome tyrosinaemia |
title | Nitisinone-Induced Keratopathy in Alkaptonuria Disease: A Case Report and Literature Review |
title_full | Nitisinone-Induced Keratopathy in Alkaptonuria Disease: A Case Report and Literature Review |
title_fullStr | Nitisinone-Induced Keratopathy in Alkaptonuria Disease: A Case Report and Literature Review |
title_full_unstemmed | Nitisinone-Induced Keratopathy in Alkaptonuria Disease: A Case Report and Literature Review |
title_short | Nitisinone-Induced Keratopathy in Alkaptonuria Disease: A Case Report and Literature Review |
title_sort | nitisinone induced keratopathy in alkaptonuria disease a case report and literature review |
topic | pseudodendritic keratitis richner–hanhart syndrome tyrosinaemia |
url | https://jcdr.net/articles/PDF/11629/35741_CE(RA1)_F(T)_PF1(AB_SS)_PN(SL).pdf |
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