Adenosine 2 receptor regulates autophagy and apoptosis to alleviate ischemia reperfusion injury in type 2 diabetes via IRE-1 signaling

Adenosine 2 receptor regulates autophagy and apoptosis to alleviate ischemia reperfusion injury in type 2 diabetes via IRE-1 signaling

Abstract Purpose This study aimed to determine the effect and mechanism of action of adenosine 2 receptor (A2R) activation on myocardial ischemia reperfusion injury (MIRI) under diabetic conditions. Methods MIRI type 2 diabetic rats and H9C2 cardiomyocytes were treated with A2R agonist and then subj...

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Bibliographic Details
Main Authors: Mohamed Bassirou Yacouba Moukeila, Erick Thokerunga, Feng He, Christian Cedric Bongolo, Yun Xia, Fuyu Wang, Adamou Foumakoye Gado, Hama Mamoudou, Shahzad Khan, Bonkano Ousseina, Hadjara Abdoulkarim Ousmane, Drissa Diarra, Jianjuan Ke, Zongze Zhang, Yanlin Wang
Format: Article
Language:English
Published: BMC 2023-03-01
Series:BMC Cardiovascular Disorders
Subjects:
Adenosine2 receptor
Myocardium
Ischemia
Reperfusion
Endoplasmic reticulum stress
Online Access:https://doi.org/10.1186/s12872-023-03116-y

Internet

https://doi.org/10.1186/s12872-023-03116-y

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