Protective Effects of Higher Exposure to Aspirin and/or Clopidogrel on the Occurrence of Hip Fracture among Diabetic Patients: A Retrospective Cohort Study
Aspirin and clopidogrel are commonly prescribed alone or together among the type 2 diabetes mellitus (T2DM) patients, and both agents could affect bone metabolism. This study aimed at demonstrating the effects of the dosage and the duration of aspirin and/or clopidogrel alone or together on the occu...
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MDPI AG
2022-10-01
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| Online Access: | https://www.mdpi.com/2227-9059/10/10/2626 |
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| author | Jui-Ting Mao Jung-Nien Lai Yi-Hsiu Fu Hei-Tung Yip Yen-Chun Lai Chung-Y. Hsu Sung-Hsiung Chen Shu-Jui Kuo |
| author_facet | Jui-Ting Mao Jung-Nien Lai Yi-Hsiu Fu Hei-Tung Yip Yen-Chun Lai Chung-Y. Hsu Sung-Hsiung Chen Shu-Jui Kuo |
| author_sort | Jui-Ting Mao |
| collection | DOAJ |
| description | Aspirin and clopidogrel are commonly prescribed alone or together among the type 2 diabetes mellitus (T2DM) patients, and both agents could affect bone metabolism. This study aimed at demonstrating the effects of the dosage and the duration of aspirin and/or clopidogrel alone or together on the occurrence of hip fracture among T2DM patients. We chose the patients newly diagnosed with T2DM and divided them into four subgroups which are under aspirin monotherapy (78,522 patients), clopidogrel monotherapy (12,752 patients), dual therapy (7209 patients), and patients not taking antiplatelet drugs (401,686 patients). We found that only higher dosage (>360 cumulative daily defined dose (cDDD)) and longer duration (≥3 years) of antiplatelet agents could be associated with lower fracture risk. Compared with the subjects taking <1-year dual agents, the risk of hip fracture was 0.38-fold for the patients taking ≥3-year dual agents. Lower dosage (28–179 cDDD) and shorter duration (1~2 years) could even be associated with higher fracture risk. Overall, the best regimen to fend off the hip fracture was the use of aspirin and clopidogrel for ≥3 years. |
| first_indexed | 2024-03-09T20:37:38Z |
| format | Article |
| id | doaj.art-225c80319cb2401f94a78392ae9b848b |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T20:37:38Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-225c80319cb2401f94a78392ae9b848b2023-11-23T23:06:09ZengMDPI AGBiomedicines2227-90592022-10-011010262610.3390/biomedicines10102626Protective Effects of Higher Exposure to Aspirin and/or Clopidogrel on the Occurrence of Hip Fracture among Diabetic Patients: A Retrospective Cohort StudyJui-Ting Mao0Jung-Nien Lai1Yi-Hsiu Fu2Hei-Tung Yip3Yen-Chun Lai4Chung-Y. Hsu5Sung-Hsiung Chen6Shu-Jui Kuo7Department of Orthopedic Surgery, China Medical University Hospital, Taichung 404, TaiwanDepartment of Chinese Medicine, China Medical University Hospital, Taichung 404, TaiwanDepartment of Education, Taichung Veterans General Hospital, Taichung 407, TaiwanManagement office for Health Data, China Medical University Hospital, Taichung 404, TaiwanSchool of Medicine, National Taiwan University, Taipei 100, TaiwanGraduate Institute of Biomedical Sciences, China Medical University, Taichung 404, TaiwanDepartment of Orthopedic Surgery, College of Medicine, Chang Gung University, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, TaiwanDepartment of Orthopedic Surgery, China Medical University Hospital, Taichung 404, TaiwanAspirin and clopidogrel are commonly prescribed alone or together among the type 2 diabetes mellitus (T2DM) patients, and both agents could affect bone metabolism. This study aimed at demonstrating the effects of the dosage and the duration of aspirin and/or clopidogrel alone or together on the occurrence of hip fracture among T2DM patients. We chose the patients newly diagnosed with T2DM and divided them into four subgroups which are under aspirin monotherapy (78,522 patients), clopidogrel monotherapy (12,752 patients), dual therapy (7209 patients), and patients not taking antiplatelet drugs (401,686 patients). We found that only higher dosage (>360 cumulative daily defined dose (cDDD)) and longer duration (≥3 years) of antiplatelet agents could be associated with lower fracture risk. Compared with the subjects taking <1-year dual agents, the risk of hip fracture was 0.38-fold for the patients taking ≥3-year dual agents. Lower dosage (28–179 cDDD) and shorter duration (1~2 years) could even be associated with higher fracture risk. Overall, the best regimen to fend off the hip fracture was the use of aspirin and clopidogrel for ≥3 years.https://www.mdpi.com/2227-9059/10/10/2626aspirinclopidogrelhip fracturetype 2 diabetes |
| spellingShingle | Jui-Ting Mao Jung-Nien Lai Yi-Hsiu Fu Hei-Tung Yip Yen-Chun Lai Chung-Y. Hsu Sung-Hsiung Chen Shu-Jui Kuo Protective Effects of Higher Exposure to Aspirin and/or Clopidogrel on the Occurrence of Hip Fracture among Diabetic Patients: A Retrospective Cohort Study Biomedicines aspirin clopidogrel hip fracture type 2 diabetes |
| title | Protective Effects of Higher Exposure to Aspirin and/or Clopidogrel on the Occurrence of Hip Fracture among Diabetic Patients: A Retrospective Cohort Study |
| title_full | Protective Effects of Higher Exposure to Aspirin and/or Clopidogrel on the Occurrence of Hip Fracture among Diabetic Patients: A Retrospective Cohort Study |
| title_fullStr | Protective Effects of Higher Exposure to Aspirin and/or Clopidogrel on the Occurrence of Hip Fracture among Diabetic Patients: A Retrospective Cohort Study |
| title_full_unstemmed | Protective Effects of Higher Exposure to Aspirin and/or Clopidogrel on the Occurrence of Hip Fracture among Diabetic Patients: A Retrospective Cohort Study |
| title_short | Protective Effects of Higher Exposure to Aspirin and/or Clopidogrel on the Occurrence of Hip Fracture among Diabetic Patients: A Retrospective Cohort Study |
| title_sort | protective effects of higher exposure to aspirin and or clopidogrel on the occurrence of hip fracture among diabetic patients a retrospective cohort study |
| topic | aspirin clopidogrel hip fracture type 2 diabetes |
| url | https://www.mdpi.com/2227-9059/10/10/2626 |
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