A novel SARS-CoV-2 IgG line-blot for evaluating discrepant IgG test results – Observations in pre-pandemic and follow-up samples of five patients

To confirm discrepant SARS-CoV-2-IgG results in four standard assays we applied for the first time a prototype of a coronavirus IgG-line-blot which employs antigens from seasonal coronaviruses, SARS-1 and SARS-CoV-2 combined with avidity testing as a confirmatory tool in a follow-up of five cases in...

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Main Authors: Andrea Steiner, Mathias Pletz, Bettina Löffler, Michael Baier
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Journal of Microbiology, Immunology and Infection
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1684118221000566
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author Andrea Steiner
Mathias Pletz
Bettina Löffler
Michael Baier
author_facet Andrea Steiner
Mathias Pletz
Bettina Löffler
Michael Baier
author_sort Andrea Steiner
collection DOAJ
description To confirm discrepant SARS-CoV-2-IgG results in four standard assays we applied for the first time a prototype of a coronavirus IgG-line-blot which employs antigens from seasonal coronaviruses, SARS-1 and SARS-CoV-2 combined with avidity testing as a confirmatory tool in a follow-up of five cases including pre-pandemic samples.
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spelling doaj.art-225e7cec6c0b4305bc54ca2e36956b132022-12-21T18:23:48ZengElsevierJournal of Microbiology, Immunology and Infection1684-11822021-10-01545979982A novel SARS-CoV-2 IgG line-blot for evaluating discrepant IgG test results – Observations in pre-pandemic and follow-up samples of five patientsAndrea Steiner0Mathias Pletz1Bettina Löffler2Michael Baier3Department of Occupational Medicine, Jena University Hospital, Jena, GermanyCentre of Infectious Diseases and Infection Control, Jena University Hospital, Jena, GermanyInstitute for Medical Microbiology, Jena University Hospital, Jena, GermanyInstitute for Medical Microbiology, Jena University Hospital, Jena, Germany; Corresponding author.To confirm discrepant SARS-CoV-2-IgG results in four standard assays we applied for the first time a prototype of a coronavirus IgG-line-blot which employs antigens from seasonal coronaviruses, SARS-1 and SARS-CoV-2 combined with avidity testing as a confirmatory tool in a follow-up of five cases including pre-pandemic samples.http://www.sciencedirect.com/science/article/pii/S1684118221000566SARS-CoV-2Specific antibodiesLine blotNucleocapsidSpike proteinCOVID-19
spellingShingle Andrea Steiner
Mathias Pletz
Bettina Löffler
Michael Baier
A novel SARS-CoV-2 IgG line-blot for evaluating discrepant IgG test results – Observations in pre-pandemic and follow-up samples of five patients
Journal of Microbiology, Immunology and Infection
SARS-CoV-2
Specific antibodies
Line blot
Nucleocapsid
Spike protein
COVID-19
title A novel SARS-CoV-2 IgG line-blot for evaluating discrepant IgG test results – Observations in pre-pandemic and follow-up samples of five patients
title_full A novel SARS-CoV-2 IgG line-blot for evaluating discrepant IgG test results – Observations in pre-pandemic and follow-up samples of five patients
title_fullStr A novel SARS-CoV-2 IgG line-blot for evaluating discrepant IgG test results – Observations in pre-pandemic and follow-up samples of five patients
title_full_unstemmed A novel SARS-CoV-2 IgG line-blot for evaluating discrepant IgG test results – Observations in pre-pandemic and follow-up samples of five patients
title_short A novel SARS-CoV-2 IgG line-blot for evaluating discrepant IgG test results – Observations in pre-pandemic and follow-up samples of five patients
title_sort novel sars cov 2 igg line blot for evaluating discrepant igg test results observations in pre pandemic and follow up samples of five patients
topic SARS-CoV-2
Specific antibodies
Line blot
Nucleocapsid
Spike protein
COVID-19
url http://www.sciencedirect.com/science/article/pii/S1684118221000566
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