Impact of Human Papillomavirus-Negative Dominance in Oropharyngeal Cancer on Overall Survival: A Population-Based Analysis in Germany from 2018 to 2020
The impact of the relation of human papillomavirus (HPV) and smoking status of oropharyngeal squamous cell carcinoma (OPSCC) on overall survival (OS) was investigated in a retrospective population-based study in Thuringia, Germany. A total of 498 patients with OPSCC (76.9% men; mean age 62.5 years)...
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| Format: | Article |
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MDPI AG
2023-11-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/21/5259 |
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| author | Mussab Kouka Laura Gerlach Jens Büntzel Holger Kaftan Daniel Böger Andreas H. Müller Thomas Ernst Orlando Guntinas-Lichius |
| author_facet | Mussab Kouka Laura Gerlach Jens Büntzel Holger Kaftan Daniel Böger Andreas H. Müller Thomas Ernst Orlando Guntinas-Lichius |
| author_sort | Mussab Kouka |
| collection | DOAJ |
| description | The impact of the relation of human papillomavirus (HPV) and smoking status of oropharyngeal squamous cell carcinoma (OPSCC) on overall survival (OS) was investigated in a retrospective population-based study in Thuringia, Germany. A total of 498 patients with OPSCC (76.9% men; mean age 62.5 years) from 2018 to 2020 were included. OPSCC cases were 37.3% HPV-positive (+) (31.2% smokers; mean incidence: 2.91/100,000 population) and 57.8% HPV-negative (63.5% smokers; mean incidence: 4.50/100,000 population). Median follow-up was 20 months. HPV+ patients had significantly better OS than HPV-negative (−) patients (HPV+: 2-year OS: 90.9%; HPV−: 2-year OS: 73.6%; <i>p</i> < 0.001). In multivariable analysis, HPV− patients (hazard ratio (HR) = 4.5; 95% confidence interval (CI): 2.4–8.6), patients with higher N classification (N2: HR = 3.3; 95% CI: 1.71–6.20; N3: HR = 3.6; 95% CI: 1.75–7.31) and with a higher cancer staging (III: HR = 5.7; 95% CI: 1.8–17.6; IV: HR = 19.3; 95% CI: 6.3–57.3) had an increased hazard of death. HPV− smokers formed the majority in Thuringia. Nicotine and alcohol habits had no impact on OS. Optimizing OPSCC therapeutic strategies due to the dominance of HPV− is more important than discussing de-escalation strategies for HPV+ patients. |
| first_indexed | 2024-03-11T11:32:23Z |
| format | Article |
| id | doaj.art-2262ffdd7bea4da2aa2904dfd13482c4 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T11:32:23Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-2262ffdd7bea4da2aa2904dfd13482c42023-11-10T15:00:24ZengMDPI AGCancers2072-66942023-11-011521525910.3390/cancers15215259Impact of Human Papillomavirus-Negative Dominance in Oropharyngeal Cancer on Overall Survival: A Population-Based Analysis in Germany from 2018 to 2020Mussab Kouka0Laura Gerlach1Jens Büntzel2Holger Kaftan3Daniel Böger4Andreas H. Müller5Thomas Ernst6Orlando Guntinas-Lichius7Department of Otorhinolaryngology, Jena University Hospital, 07747 Jena, GermanyDepartment of Otorhinolaryngology, Jena University Hospital, 07747 Jena, GermanyDepartment of Otorhinolaryngology, Suedharzklinikum Nordhausen, 99734 Nordhausen, GermanyDepartment of Otorhinolaryngology, Helios-Klinikum Erfurt, 99089 Erfurt, GermanyDepartment of Otorhinolaryngology, SRH Zentralklinikum Suhl, 98527 Suhl, GermanyDepartment of Otorhinolaryngology, SRH Wald-Klinikum Gera, 07548 Gera, GermanyUniversity Tumor Center, Jena University Hospital, 07747 Jena, GermanyDepartment of Otorhinolaryngology, Jena University Hospital, 07747 Jena, GermanyThe impact of the relation of human papillomavirus (HPV) and smoking status of oropharyngeal squamous cell carcinoma (OPSCC) on overall survival (OS) was investigated in a retrospective population-based study in Thuringia, Germany. A total of 498 patients with OPSCC (76.9% men; mean age 62.5 years) from 2018 to 2020 were included. OPSCC cases were 37.3% HPV-positive (+) (31.2% smokers; mean incidence: 2.91/100,000 population) and 57.8% HPV-negative (63.5% smokers; mean incidence: 4.50/100,000 population). Median follow-up was 20 months. HPV+ patients had significantly better OS than HPV-negative (−) patients (HPV+: 2-year OS: 90.9%; HPV−: 2-year OS: 73.6%; <i>p</i> < 0.001). In multivariable analysis, HPV− patients (hazard ratio (HR) = 4.5; 95% confidence interval (CI): 2.4–8.6), patients with higher N classification (N2: HR = 3.3; 95% CI: 1.71–6.20; N3: HR = 3.6; 95% CI: 1.75–7.31) and with a higher cancer staging (III: HR = 5.7; 95% CI: 1.8–17.6; IV: HR = 19.3; 95% CI: 6.3–57.3) had an increased hazard of death. HPV− smokers formed the majority in Thuringia. Nicotine and alcohol habits had no impact on OS. Optimizing OPSCC therapeutic strategies due to the dominance of HPV− is more important than discussing de-escalation strategies for HPV+ patients.https://www.mdpi.com/2072-6694/15/21/5259HPVoropharyngeal cancerhead and neck cancersurvival |
| spellingShingle | Mussab Kouka Laura Gerlach Jens Büntzel Holger Kaftan Daniel Böger Andreas H. Müller Thomas Ernst Orlando Guntinas-Lichius Impact of Human Papillomavirus-Negative Dominance in Oropharyngeal Cancer on Overall Survival: A Population-Based Analysis in Germany from 2018 to 2020 Cancers HPV oropharyngeal cancer head and neck cancer survival |
| title | Impact of Human Papillomavirus-Negative Dominance in Oropharyngeal Cancer on Overall Survival: A Population-Based Analysis in Germany from 2018 to 2020 |
| title_full | Impact of Human Papillomavirus-Negative Dominance in Oropharyngeal Cancer on Overall Survival: A Population-Based Analysis in Germany from 2018 to 2020 |
| title_fullStr | Impact of Human Papillomavirus-Negative Dominance in Oropharyngeal Cancer on Overall Survival: A Population-Based Analysis in Germany from 2018 to 2020 |
| title_full_unstemmed | Impact of Human Papillomavirus-Negative Dominance in Oropharyngeal Cancer on Overall Survival: A Population-Based Analysis in Germany from 2018 to 2020 |
| title_short | Impact of Human Papillomavirus-Negative Dominance in Oropharyngeal Cancer on Overall Survival: A Population-Based Analysis in Germany from 2018 to 2020 |
| title_sort | impact of human papillomavirus negative dominance in oropharyngeal cancer on overall survival a population based analysis in germany from 2018 to 2020 |
| topic | HPV oropharyngeal cancer head and neck cancer survival |
| url | https://www.mdpi.com/2072-6694/15/21/5259 |
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