Intradermal Delivery of Synthetic mRNA Using Hollow Microneedles for Efficient and Rapid Production of Exogenous Proteins in Skin

Intradermal Delivery of Synthetic mRNA Using Hollow Microneedles for Efficient and Rapid Production of Exogenous Proteins in Skin

In recent years, synthetic mRNA-based applications to produce desired exogenous proteins in cells have been gaining importance. However, systemic delivery of synthetic mRNA can result in unspecific uptake into undesired cells or organs and, thereby, fail to target desired cells. Thus, local and targ...

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Bibliographic Details
Main Authors: Sonia Golombek, Martin Pilz, Heidrun Steinle, Efrat Kochba, Yotam Levin, Dominique Lunter, Christian Schlensak, Hans Peter Wendel, Meltem Avci-Adali
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
synthetic mRNA
microneedles
intradermal
delivery
protein expression
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253118300350

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