Dose-response analysis in the joint action of two effectors. A new approach to simulation, identification and modelling of some basic interactions.
In systems with several effectors, the results of dose-response (DR) experiments are usually assessed by checking them against two hypotheses: independent action (IA) and concentration addition (CA). Both are useful simplifications, but do not represent the only possible responses, and avoid to a la...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3634793?pdf=render |
| _version_ | 1818325150972510208 |
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| author | Miguel Anxo Murado García Miguel Ángel Prieto Lage |
| author_facet | Miguel Anxo Murado García Miguel Ángel Prieto Lage |
| author_sort | Miguel Anxo Murado García |
| collection | DOAJ |
| description | In systems with several effectors, the results of dose-response (DR) experiments are usually assessed by checking them against two hypotheses: independent action (IA) and concentration addition (CA). Both are useful simplifications, but do not represent the only possible responses, and avoid to a large extent the analysis of the interactions that are possible in the system. In addition, these are often applied in such a way that they produce insufficient descriptions of the problem that raises them, frequent inconclusive cases and doubtful decisions. In this work a generative approach is attempted, starting from some simple mechanisms necessarily underlying the response of an elementary biological entity to an effector agent. A set of simulations is formulated next through an equally simple system of logical rules, and several families of virtual responses are thus generated. These families include typical responses of IA and CA modes of action, other ones not less probable from a physiological point of view, and even other derived from common and expectable forms of interactions. The analysis of these responses enabled, firstly, to relate some phenomenological regularities with some general mechanistic principles, and to detect several causes by which the IA-CA dualism is necessarily ambiguous. Secondly, it allowed identifying different forms of synergy and antagonism that contribute to explain some controversial aspects of these notions. Finally, it led to propose two sets of explicit algebraic equations that describe accurately a wide diversity of possible and realistic responses. |
| first_indexed | 2024-12-13T11:39:55Z |
| format | Article |
| id | doaj.art-226385baf8db449ba7f97d462242a649 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T11:39:55Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-226385baf8db449ba7f97d462242a6492022-12-21T23:47:40ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0184e6139110.1371/journal.pone.0061391Dose-response analysis in the joint action of two effectors. A new approach to simulation, identification and modelling of some basic interactions.Miguel Anxo Murado GarcíaMiguel Ángel Prieto LageIn systems with several effectors, the results of dose-response (DR) experiments are usually assessed by checking them against two hypotheses: independent action (IA) and concentration addition (CA). Both are useful simplifications, but do not represent the only possible responses, and avoid to a large extent the analysis of the interactions that are possible in the system. In addition, these are often applied in such a way that they produce insufficient descriptions of the problem that raises them, frequent inconclusive cases and doubtful decisions. In this work a generative approach is attempted, starting from some simple mechanisms necessarily underlying the response of an elementary biological entity to an effector agent. A set of simulations is formulated next through an equally simple system of logical rules, and several families of virtual responses are thus generated. These families include typical responses of IA and CA modes of action, other ones not less probable from a physiological point of view, and even other derived from common and expectable forms of interactions. The analysis of these responses enabled, firstly, to relate some phenomenological regularities with some general mechanistic principles, and to detect several causes by which the IA-CA dualism is necessarily ambiguous. Secondly, it allowed identifying different forms of synergy and antagonism that contribute to explain some controversial aspects of these notions. Finally, it led to propose two sets of explicit algebraic equations that describe accurately a wide diversity of possible and realistic responses.http://europepmc.org/articles/PMC3634793?pdf=render |
| spellingShingle | Miguel Anxo Murado García Miguel Ángel Prieto Lage Dose-response analysis in the joint action of two effectors. A new approach to simulation, identification and modelling of some basic interactions. PLoS ONE |
| title | Dose-response analysis in the joint action of two effectors. A new approach to simulation, identification and modelling of some basic interactions. |
| title_full | Dose-response analysis in the joint action of two effectors. A new approach to simulation, identification and modelling of some basic interactions. |
| title_fullStr | Dose-response analysis in the joint action of two effectors. A new approach to simulation, identification and modelling of some basic interactions. |
| title_full_unstemmed | Dose-response analysis in the joint action of two effectors. A new approach to simulation, identification and modelling of some basic interactions. |
| title_short | Dose-response analysis in the joint action of two effectors. A new approach to simulation, identification and modelling of some basic interactions. |
| title_sort | dose response analysis in the joint action of two effectors a new approach to simulation identification and modelling of some basic interactions |
| url | http://europepmc.org/articles/PMC3634793?pdf=render |
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