The Prognostic Utilities of Various Risk Factors for Laryngeal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis
<i>Objective</i>: To assess the prognostic utilities of various risk factors for laryngeal squamous cell carcinoma. <i>Methods</i>: Six databases were searched to January 2022. Hazard ratios for overall survival and disease-free survival were collected and study characteristi...
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MDPI AG
2023-03-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/3/497 |
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| author | Do Hyun Kim Sung Won Kim Jae Sang Han Geun-Jeon Kim Mohammed Abdullah Basurrah Se Hwan Hwang |
| author_facet | Do Hyun Kim Sung Won Kim Jae Sang Han Geun-Jeon Kim Mohammed Abdullah Basurrah Se Hwan Hwang |
| author_sort | Do Hyun Kim |
| collection | DOAJ |
| description | <i>Objective</i>: To assess the prognostic utilities of various risk factors for laryngeal squamous cell carcinoma. <i>Methods</i>: Six databases were searched to January 2022. Hazard ratios for overall survival and disease-free survival were collected and study characteristics were recorded. The risk of bias was evaluated using the Newcastle–Ottawa scale. <i>Results</i>: Twenty-eight studies involving 32,128 patients were finally included. In terms of overall survival, older age, a history of alcohol consumption, a high Charlson comorbidity index score, a high TNM stage (III and IV), a high tumor stage (III and IV), nodal involvement, poor pathological differentiation, primary chemoradiotherapy and radiotherapy were associated with increased risks of death. In terms of disease-free survival, older age (≥60 years), TNM stages III and IV, tumor stages III and IV, supraglottic tumors, and nodal involvement all increased the risk of death. <i>Conclusions</i>: The TNM stage importantly predicts overall survival, and tumor location predicts the disease-free survival of patients with laryngeal squamous cell carcinoma. Of patients with risk factors, the Charlson comorbidity index usefully predicts overall survival. |
| first_indexed | 2024-03-11T06:12:04Z |
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| id | doaj.art-2266311947de4b8193dcc385c41355d5 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-11T06:12:04Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-2266311947de4b8193dcc385c41355d52023-11-17T12:31:28ZengMDPI AGMedicina1010-660X1648-91442023-03-0159349710.3390/medicina59030497The Prognostic Utilities of Various Risk Factors for Laryngeal Squamous Cell Carcinoma: A Systematic Review and Meta-AnalysisDo Hyun Kim0Sung Won Kim1Jae Sang Han2Geun-Jeon Kim3Mohammed Abdullah Basurrah4Se Hwan Hwang5Department of Otolaryngology-Head and Neck Surgery, Seoul Saint Mary’s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 06591, Republic of KoreaDepartment of Otolaryngology-Head and Neck Surgery, Seoul Saint Mary’s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 06591, Republic of KoreaDepartment of Otolaryngology-Head and Neck Surgery, Seoul Saint Mary’s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 06591, Republic of KoreaDepartment of Otolaryngology-Head and Neck Surgery, Seoul Saint Mary’s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 06591, Republic of KoreaDepartment of Surgery, College of Medicine, Taif University, Taif 21944, Saudi ArabiaDepartment of Otolaryngology-Head and Neck Surgery, Bucheon Saint Mary’s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea<i>Objective</i>: To assess the prognostic utilities of various risk factors for laryngeal squamous cell carcinoma. <i>Methods</i>: Six databases were searched to January 2022. Hazard ratios for overall survival and disease-free survival were collected and study characteristics were recorded. The risk of bias was evaluated using the Newcastle–Ottawa scale. <i>Results</i>: Twenty-eight studies involving 32,128 patients were finally included. In terms of overall survival, older age, a history of alcohol consumption, a high Charlson comorbidity index score, a high TNM stage (III and IV), a high tumor stage (III and IV), nodal involvement, poor pathological differentiation, primary chemoradiotherapy and radiotherapy were associated with increased risks of death. In terms of disease-free survival, older age (≥60 years), TNM stages III and IV, tumor stages III and IV, supraglottic tumors, and nodal involvement all increased the risk of death. <i>Conclusions</i>: The TNM stage importantly predicts overall survival, and tumor location predicts the disease-free survival of patients with laryngeal squamous cell carcinoma. Of patients with risk factors, the Charlson comorbidity index usefully predicts overall survival.https://www.mdpi.com/1648-9144/59/3/497prognosisrisk factorssurvival ratelaryngeal neoplasmsmeta-analysis |
| spellingShingle | Do Hyun Kim Sung Won Kim Jae Sang Han Geun-Jeon Kim Mohammed Abdullah Basurrah Se Hwan Hwang The Prognostic Utilities of Various Risk Factors for Laryngeal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis Medicina prognosis risk factors survival rate laryngeal neoplasms meta-analysis |
| title | The Prognostic Utilities of Various Risk Factors for Laryngeal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis |
| title_full | The Prognostic Utilities of Various Risk Factors for Laryngeal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis |
| title_fullStr | The Prognostic Utilities of Various Risk Factors for Laryngeal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | The Prognostic Utilities of Various Risk Factors for Laryngeal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis |
| title_short | The Prognostic Utilities of Various Risk Factors for Laryngeal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis |
| title_sort | prognostic utilities of various risk factors for laryngeal squamous cell carcinoma a systematic review and meta analysis |
| topic | prognosis risk factors survival rate laryngeal neoplasms meta-analysis |
| url | https://www.mdpi.com/1648-9144/59/3/497 |
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