Implication of functional platelet activity in pathogenesis of Q-fever
Aim. To ascertain the role of platelets in pathogenesis of clinical symptoms in patients with Q-fever. Material and methods. We studied hemostasis with estimation of functional platelet activity in 49 patients with Q-fever. Results. Hemorrhagic syndrome (HS) occurred in 34,4 % patients with Q-fever...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2011-11-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/30949 |
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| author | Elena Nikolaevna Lazareva Viktor Vasil'evich Maleev Khalip M Galimzyanov Aleksandr Vasil'evich Burkin Alla Markovna Polyakova Ol'ga Semenovna Astrina M A Babaeva M M Khok E N Lazareva V V Maleev Kh M Galimzyanov A V Burkin M M Khok A M Polyakova O S Astrina M A Babaeva |
| author_facet | Elena Nikolaevna Lazareva Viktor Vasil'evich Maleev Khalip M Galimzyanov Aleksandr Vasil'evich Burkin Alla Markovna Polyakova Ol'ga Semenovna Astrina M A Babaeva M M Khok E N Lazareva V V Maleev Kh M Galimzyanov A V Burkin M M Khok A M Polyakova O S Astrina M A Babaeva |
| author_sort | Elena Nikolaevna Lazareva |
| collection | DOAJ |
| description | Aim. To ascertain the role of platelets in pathogenesis of clinical symptoms in patients with Q-fever.
Material and methods. We studied hemostasis with estimation of functional platelet activity in 49 patients with Q-fever.
Results. Hemorrhagic syndrome (HS) occurred in 34,4 % patients with Q-fever (QF) during seasonal rise of morbidity. HS manifested with petechiae (12%), hematomas (32 %), nasal bleeding (17 %), stomatorrhagia (9 %), melena (12 %). Characteristics and duration of such symptoms as weakness (100%), myalgia (72%), arthralgia (52.9%) suggested hemocoagulatory disorders as a cause of the symptoms appearance. At the height of the disease thrombocytopenia was accompanied with inhibition of platelet aggregation activity, but regression of the clinical symptoms was associated with an increase in platelet count and platelet hyperaggregation. Fibrinogen content was elevated during hospitalization in 50% patients.
Conclusion. Clinical manifestations of HS are typical for Q-fever prevalent in the Astrakhan Region. Hemostatic disorders because of altered functional activity of platelets were registered in all the cases and evidence for pathogenetic unbalance of homeostasis in Q-fever patients. |
| first_indexed | 2024-12-13T12:03:03Z |
| format | Article |
| id | doaj.art-2267694cccbb48cf88eb79bd6e0c90fb |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-13T12:03:03Z |
| publishDate | 2011-11-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-2267694cccbb48cf88eb79bd6e0c90fb2022-12-21T23:47:03Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422011-11-018311515527965Implication of functional platelet activity in pathogenesis of Q-feverElena Nikolaevna LazarevaViktor Vasil'evich MaleevKhalip M GalimzyanovAleksandr Vasil'evich BurkinAlla Markovna PolyakovaOl'ga Semenovna AstrinaM A BabaevaM M KhokE N Lazareva0V V Maleev1Kh M Galimzyanov2A V Burkin3M M Khok4A M Polyakova5O S Astrina6M A Babaeva7Regional Infectious Hospital, Astrakhan;State Medical Academy, AstrakhanCentral Research Institute of Epidemiology, AstrakhanState Medical Academy, AstrakhanRegional Infectious Hospital, AstrakhanRegional Infectious Hospital, AstrakhanCentral Research Institute of Epidemiology, AstrakhanCentral Research Institute of Epidemiology, AstrakhanRegional Infectious Hospital, AstrakhanAim. To ascertain the role of platelets in pathogenesis of clinical symptoms in patients with Q-fever. Material and methods. We studied hemostasis with estimation of functional platelet activity in 49 patients with Q-fever. Results. Hemorrhagic syndrome (HS) occurred in 34,4 % patients with Q-fever (QF) during seasonal rise of morbidity. HS manifested with petechiae (12%), hematomas (32 %), nasal bleeding (17 %), stomatorrhagia (9 %), melena (12 %). Characteristics and duration of such symptoms as weakness (100%), myalgia (72%), arthralgia (52.9%) suggested hemocoagulatory disorders as a cause of the symptoms appearance. At the height of the disease thrombocytopenia was accompanied with inhibition of platelet aggregation activity, but regression of the clinical symptoms was associated with an increase in platelet count and platelet hyperaggregation. Fibrinogen content was elevated during hospitalization in 50% patients. Conclusion. Clinical manifestations of HS are typical for Q-fever prevalent in the Astrakhan Region. Hemostatic disorders because of altered functional activity of platelets were registered in all the cases and evidence for pathogenetic unbalance of homeostasis in Q-fever patients.https://ter-arkhiv.ru/0040-3660/article/view/30949hemorrhagic syndromethrombocytopeniahypo- and hyperaggregation of plateletsq-fever |
| spellingShingle | Elena Nikolaevna Lazareva Viktor Vasil'evich Maleev Khalip M Galimzyanov Aleksandr Vasil'evich Burkin Alla Markovna Polyakova Ol'ga Semenovna Astrina M A Babaeva M M Khok E N Lazareva V V Maleev Kh M Galimzyanov A V Burkin M M Khok A M Polyakova O S Astrina M A Babaeva Implication of functional platelet activity in pathogenesis of Q-fever Терапевтический архив hemorrhagic syndrome thrombocytopenia hypo- and hyperaggregation of platelets q-fever |
| title | Implication of functional platelet activity in pathogenesis of Q-fever |
| title_full | Implication of functional platelet activity in pathogenesis of Q-fever |
| title_fullStr | Implication of functional platelet activity in pathogenesis of Q-fever |
| title_full_unstemmed | Implication of functional platelet activity in pathogenesis of Q-fever |
| title_short | Implication of functional platelet activity in pathogenesis of Q-fever |
| title_sort | implication of functional platelet activity in pathogenesis of q fever |
| topic | hemorrhagic syndrome thrombocytopenia hypo- and hyperaggregation of platelets q-fever |
| url | https://ter-arkhiv.ru/0040-3660/article/view/30949 |
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