Synthesis and Evaluation of Rutin–Hydroxypropyl β-Cyclodextrin Inclusion Complexes Embedded in Xanthan Gum-Based (HPMC-<i>g</i>-AMPS) Hydrogels for Oral Controlled Drug Delivery
Oxidants play a significant role in causing oxidative stress in the body, which contributes to the development of diseases. Rutin—a powerful antioxidant—may be useful in the prevention and treatment of various diseases by scavenging oxidants and reducing oxidative stress. However, low solubility and...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/3/552 |
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| author | Abid Naeem Chengqun Yu Zhenzhong Zang Weifeng Zhu Xuezhen Deng Yongmei Guan |
| author_facet | Abid Naeem Chengqun Yu Zhenzhong Zang Weifeng Zhu Xuezhen Deng Yongmei Guan |
| author_sort | Abid Naeem |
| collection | DOAJ |
| description | Oxidants play a significant role in causing oxidative stress in the body, which contributes to the development of diseases. Rutin—a powerful antioxidant—may be useful in the prevention and treatment of various diseases by scavenging oxidants and reducing oxidative stress. However, low solubility and oral bioavailability have restricted its use. Due to the hydrophobic nature of rutin, it cannot be easily loaded inside hydrogels. Therefore, first rutin inclusion complexes (<i>RIC</i>) with hydroxypropyl-β-cyclodextrin (HP-βCD) were prepared to improve its solubility, followed by incorporation into xanthan gum-based (hydroxypropyl methylcellulose-grafted-2-acrylamido -2-methyl-1-propane sulfonic acid) hydrogels for controlled drug release in order to improve the bioavailability. Rutin inclusion complexes and hydrogels were validated by FTIR, XRD, SEM, TGA, and DSC. The highest swelling ratio and drug release occurred at pH 1.2 (28% swelling ratio and 70% drug release) versus pH 7.4 (22% swelling ratio, 65% drug release) after 48 h. Hydrogels showed high porosity (94%) and biodegradation (9% in 1 week in phosphate buffer saline). Moreover, in vitro antioxidative and antibacterial studies (<i>Staphylococcus aureus</i>, <i>Pseudomonas aeruginosa</i>, and <i>Escherichia coli</i>) confirmed the antioxidative and antibacterial potential of the developed hydrogels. |
| first_indexed | 2024-03-11T07:00:16Z |
| format | Article |
| id | doaj.art-22684138d488461785e06e7ecf8b2138 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T07:00:16Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-22684138d488461785e06e7ecf8b21382023-11-17T09:16:23ZengMDPI AGAntioxidants2076-39212023-02-0112355210.3390/antiox12030552Synthesis and Evaluation of Rutin–Hydroxypropyl β-Cyclodextrin Inclusion Complexes Embedded in Xanthan Gum-Based (HPMC-<i>g</i>-AMPS) Hydrogels for Oral Controlled Drug DeliveryAbid Naeem0Chengqun Yu1Zhenzhong Zang2Weifeng Zhu3Xuezhen Deng4Yongmei Guan5Key Laboratory of Modern Preparation of Traditional Chinese Medicines, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, ChinaKey Laboratory of Modern Preparation of Traditional Chinese Medicines, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, ChinaKey Laboratory of Modern Preparation of Traditional Chinese Medicines, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, ChinaKey Laboratory of Modern Preparation of Traditional Chinese Medicines, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, ChinaSchool of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, ChinaKey Laboratory of Modern Preparation of Traditional Chinese Medicines, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, ChinaOxidants play a significant role in causing oxidative stress in the body, which contributes to the development of diseases. Rutin—a powerful antioxidant—may be useful in the prevention and treatment of various diseases by scavenging oxidants and reducing oxidative stress. However, low solubility and oral bioavailability have restricted its use. Due to the hydrophobic nature of rutin, it cannot be easily loaded inside hydrogels. Therefore, first rutin inclusion complexes (<i>RIC</i>) with hydroxypropyl-β-cyclodextrin (HP-βCD) were prepared to improve its solubility, followed by incorporation into xanthan gum-based (hydroxypropyl methylcellulose-grafted-2-acrylamido -2-methyl-1-propane sulfonic acid) hydrogels for controlled drug release in order to improve the bioavailability. Rutin inclusion complexes and hydrogels were validated by FTIR, XRD, SEM, TGA, and DSC. The highest swelling ratio and drug release occurred at pH 1.2 (28% swelling ratio and 70% drug release) versus pH 7.4 (22% swelling ratio, 65% drug release) after 48 h. Hydrogels showed high porosity (94%) and biodegradation (9% in 1 week in phosphate buffer saline). Moreover, in vitro antioxidative and antibacterial studies (<i>Staphylococcus aureus</i>, <i>Pseudomonas aeruginosa</i>, and <i>Escherichia coli</i>) confirmed the antioxidative and antibacterial potential of the developed hydrogels.https://www.mdpi.com/2076-3921/12/3/552hydrogelsflavonoidsanti-oxidantsinclusion complexesoral formulations |
| spellingShingle | Abid Naeem Chengqun Yu Zhenzhong Zang Weifeng Zhu Xuezhen Deng Yongmei Guan Synthesis and Evaluation of Rutin–Hydroxypropyl β-Cyclodextrin Inclusion Complexes Embedded in Xanthan Gum-Based (HPMC-<i>g</i>-AMPS) Hydrogels for Oral Controlled Drug Delivery Antioxidants hydrogels flavonoids anti-oxidants inclusion complexes oral formulations |
| title | Synthesis and Evaluation of Rutin–Hydroxypropyl β-Cyclodextrin Inclusion Complexes Embedded in Xanthan Gum-Based (HPMC-<i>g</i>-AMPS) Hydrogels for Oral Controlled Drug Delivery |
| title_full | Synthesis and Evaluation of Rutin–Hydroxypropyl β-Cyclodextrin Inclusion Complexes Embedded in Xanthan Gum-Based (HPMC-<i>g</i>-AMPS) Hydrogels for Oral Controlled Drug Delivery |
| title_fullStr | Synthesis and Evaluation of Rutin–Hydroxypropyl β-Cyclodextrin Inclusion Complexes Embedded in Xanthan Gum-Based (HPMC-<i>g</i>-AMPS) Hydrogels for Oral Controlled Drug Delivery |
| title_full_unstemmed | Synthesis and Evaluation of Rutin–Hydroxypropyl β-Cyclodextrin Inclusion Complexes Embedded in Xanthan Gum-Based (HPMC-<i>g</i>-AMPS) Hydrogels for Oral Controlled Drug Delivery |
| title_short | Synthesis and Evaluation of Rutin–Hydroxypropyl β-Cyclodextrin Inclusion Complexes Embedded in Xanthan Gum-Based (HPMC-<i>g</i>-AMPS) Hydrogels for Oral Controlled Drug Delivery |
| title_sort | synthesis and evaluation of rutin hydroxypropyl β cyclodextrin inclusion complexes embedded in xanthan gum based hpmc i g i amps hydrogels for oral controlled drug delivery |
| topic | hydrogels flavonoids anti-oxidants inclusion complexes oral formulations |
| url | https://www.mdpi.com/2076-3921/12/3/552 |
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