uPAR EXPRESSION IN CANINE NORMAL PROSTATE AND WITH PROLIFERATIVE DISORDERS
Prostatic lesions such as prostatic intraepithelial neoplasia (PIN) and proliferative inflammatory atrophy (PIA) are studied in human and canine species due to their malignance potential. The plasminogen activator (PA) system has been suggested to play a central role in cell adhesion, angiogenesis,...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universidade Federal de Goiás
2013-06-01
|
| Series: | Ciência Animal Brasileira |
| Subjects: | |
| Online Access: | http://www.revistas.ufg.br/index.php/vet/article/view/18930/14544 |
| _version_ | 1819203166747492352 |
|---|---|
| author | Mariana Rodrigues Faleiro Denise Caroline Toledo Marcela Marcondes Pinto Rodrigues Renee Laufer Amorim Luiz Augusto Batista Brito Adilson Donizeti Damasceno Veridiana Maria Brianezi Dignani De Moura |
| author_facet | Mariana Rodrigues Faleiro Denise Caroline Toledo Marcela Marcondes Pinto Rodrigues Renee Laufer Amorim Luiz Augusto Batista Brito Adilson Donizeti Damasceno Veridiana Maria Brianezi Dignani De Moura |
| author_sort | Mariana Rodrigues Faleiro |
| collection | DOAJ |
| description | Prostatic lesions such as prostatic intraepithelial neoplasia (PIN) and proliferative inflammatory atrophy (PIA) are studied in human and canine species due to their malignance potential. The plasminogen activator (PA) system has been suggested to play a central role in cell adhesion, angiogenesis, inflammation, and tumor invasion. The urokinase-type plasminogen activator receptor (uPAR) is a component of the PA, with a range of expression in tumor and stromal cells. In this study, uPAR expression in both canine normal prostates and with proliferative disorders (benign prostatic hyperplasia-BPH, proliferative inflammatory atrophy-PIA, prostatic intraepithelial neoplasia-PIN, and carcinoma-PC) was evaluated by immunohistochemistry in a tissue microarray (TMA) slide to establish the role of this enzyme in extracellular matrix (ECM) remodeling and in the processes of tissue invasion. A total of 298 cores and 355 diagnoses were obtained, with 36 (10.1%) normal prostates, 46 (13.0%) with BPH, 128 (36.1%) with PIA, 74 (20.8%) with PIN and 71 (20.0%) with PC. There is variation in the expression of uPAR in canine prostate according to the lesion, with lower expression in normal tissue and with BPH, and higher expression in tissue with PIA, PIN and PC. The high expression of uPAR in inflammatory and neoplastic microenvironment indicates increased proteolytic activity in canine prostates with PIA, PIN, and PC. |
| first_indexed | 2024-12-23T04:15:36Z |
| format | Article |
| id | doaj.art-226a130f8806457cb65a1ac9e1133fd3 |
| institution | Directory Open Access Journal |
| issn | 1518-2797 1809-6891 |
| language | English |
| last_indexed | 2024-12-23T04:15:36Z |
| publishDate | 2013-06-01 |
| publisher | Universidade Federal de Goiás |
| record_format | Article |
| series | Ciência Animal Brasileira |
| spelling | doaj.art-226a130f8806457cb65a1ac9e1133fd32022-12-21T18:00:22ZengUniversidade Federal de GoiásCiência Animal Brasileira1518-27971809-68912013-06-0114223724410.5216/cab.v14i2.18930uPAR EXPRESSION IN CANINE NORMAL PROSTATE AND WITH PROLIFERATIVE DISORDERSMariana Rodrigues FaleiroDenise Caroline ToledoMarcela Marcondes Pinto RodriguesRenee Laufer AmorimLuiz Augusto Batista BritoAdilson Donizeti DamascenoVeridiana Maria Brianezi Dignani De MouraProstatic lesions such as prostatic intraepithelial neoplasia (PIN) and proliferative inflammatory atrophy (PIA) are studied in human and canine species due to their malignance potential. The plasminogen activator (PA) system has been suggested to play a central role in cell adhesion, angiogenesis, inflammation, and tumor invasion. The urokinase-type plasminogen activator receptor (uPAR) is a component of the PA, with a range of expression in tumor and stromal cells. In this study, uPAR expression in both canine normal prostates and with proliferative disorders (benign prostatic hyperplasia-BPH, proliferative inflammatory atrophy-PIA, prostatic intraepithelial neoplasia-PIN, and carcinoma-PC) was evaluated by immunohistochemistry in a tissue microarray (TMA) slide to establish the role of this enzyme in extracellular matrix (ECM) remodeling and in the processes of tissue invasion. A total of 298 cores and 355 diagnoses were obtained, with 36 (10.1%) normal prostates, 46 (13.0%) with BPH, 128 (36.1%) with PIA, 74 (20.8%) with PIN and 71 (20.0%) with PC. There is variation in the expression of uPAR in canine prostate according to the lesion, with lower expression in normal tissue and with BPH, and higher expression in tissue with PIA, PIN and PC. The high expression of uPAR in inflammatory and neoplastic microenvironment indicates increased proteolytic activity in canine prostates with PIA, PIN, and PC.http://www.revistas.ufg.br/index.php/vet/article/view/18930/14544CD87PIAPINprostatic carcinomaTMA. |
| spellingShingle | Mariana Rodrigues Faleiro Denise Caroline Toledo Marcela Marcondes Pinto Rodrigues Renee Laufer Amorim Luiz Augusto Batista Brito Adilson Donizeti Damasceno Veridiana Maria Brianezi Dignani De Moura uPAR EXPRESSION IN CANINE NORMAL PROSTATE AND WITH PROLIFERATIVE DISORDERS Ciência Animal Brasileira CD87 PIA PIN prostatic carcinoma TMA. |
| title | uPAR EXPRESSION IN CANINE NORMAL PROSTATE AND WITH PROLIFERATIVE DISORDERS |
| title_full | uPAR EXPRESSION IN CANINE NORMAL PROSTATE AND WITH PROLIFERATIVE DISORDERS |
| title_fullStr | uPAR EXPRESSION IN CANINE NORMAL PROSTATE AND WITH PROLIFERATIVE DISORDERS |
| title_full_unstemmed | uPAR EXPRESSION IN CANINE NORMAL PROSTATE AND WITH PROLIFERATIVE DISORDERS |
| title_short | uPAR EXPRESSION IN CANINE NORMAL PROSTATE AND WITH PROLIFERATIVE DISORDERS |
| title_sort | upar expression in canine normal prostate and with proliferative disorders |
| topic | CD87 PIA PIN prostatic carcinoma TMA. |
| url | http://www.revistas.ufg.br/index.php/vet/article/view/18930/14544 |
| work_keys_str_mv | AT marianarodriguesfaleiro uparexpressionincaninenormalprostateandwithproliferativedisorders AT denisecarolinetoledo uparexpressionincaninenormalprostateandwithproliferativedisorders AT marcelamarcondespintorodrigues uparexpressionincaninenormalprostateandwithproliferativedisorders AT reneelauferamorim uparexpressionincaninenormalprostateandwithproliferativedisorders AT luizaugustobatistabrito uparexpressionincaninenormalprostateandwithproliferativedisorders AT adilsondonizetidamasceno uparexpressionincaninenormalprostateandwithproliferativedisorders AT veridianamariabrianezidignanidemoura uparexpressionincaninenormalprostateandwithproliferativedisorders |