Discriminant Profiles of Volatile Compounds in the Alveolar Air of Patients with Squamous Cell Lung Cancer, Lung Adenocarcinoma or Colon Cancer
The objective of the present work was to analyze volatile compounds in alveolar air in patients with squamous cell lung cancer, lung adenocarcinoma or colon cancer, to prepare algorithms able to discriminate such specific pathological conditions. The concentration of 95 volatile compounds was measur...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/3/550 |
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| author | Leonardo Politi Lorenzo Monasta Maria Novella Rigressi Andrea Princivalle Alessandro Gonfiotti Gianna Camiciottoli Luigi Perbellini |
| author_facet | Leonardo Politi Lorenzo Monasta Maria Novella Rigressi Andrea Princivalle Alessandro Gonfiotti Gianna Camiciottoli Luigi Perbellini |
| author_sort | Leonardo Politi |
| collection | DOAJ |
| description | The objective of the present work was to analyze volatile compounds in alveolar air in patients with squamous cell lung cancer, lung adenocarcinoma or colon cancer, to prepare algorithms able to discriminate such specific pathological conditions. The concentration of 95 volatile compounds was measured in the alveolar air of 45 control subjects, 36 patients with lung adenocarcinoma, 25 patients with squamous cell lung cancer and 52 patients with colon cancer. Volatile compounds were measured with ion molecule reaction mass spectrometry (IMR-MS). An iterated least absolute shrinkage and selection operator multivariate logistic regression model was used to generate specific algorithms and discriminate control subjects from patients with different kinds of cancer. The final predictive models reached the following performance: by using 11 compounds, patients with lung adenocarcinoma were identified with a sensitivity of 86% and specificity of 84%; nine compounds allowed us to identify patients with lung squamous cell carcinoma with a sensitivity of 88% and specificity of 84%; patients with colon adenocarcinoma could be identified with a sensitivity of 96% and a specificity of 73% using a model comprising 13 volatile compounds. The different alveolar profiles of volatile compounds, obtained from patients with three different kinds of cancer, suggest dissimilar biological–biochemistry conditions; each kind of cancer has probably got a specific alveolar profile. |
| first_indexed | 2024-03-09T04:02:13Z |
| format | Article |
| id | doaj.art-226c9bda6a3c4473aeba77731bf84053 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T04:02:13Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-226c9bda6a3c4473aeba77731bf840532023-12-03T14:10:51ZengMDPI AGMolecules1420-30492021-01-0126355010.3390/molecules26030550Discriminant Profiles of Volatile Compounds in the Alveolar Air of Patients with Squamous Cell Lung Cancer, Lung Adenocarcinoma or Colon CancerLeonardo Politi0Lorenzo Monasta1Maria Novella Rigressi2Andrea Princivalle3Alessandro Gonfiotti4Gianna Camiciottoli5Luigi Perbellini6Department of Clinical and Experimental Medicine, Careggi University Hospital, 50134 Florence, ItalyInstitute for Maternal and Child Health—IRCCS Burlo Garofolo, 34137 Trieste, ItalyDepartment of Clinical and Experimental Medicine, Careggi University Hospital, 50134 Florence, ItalyOccupational Medicine, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, ItalyDepartment of Clinical and Experimental Medicine, Careggi University Hospital, 50134 Florence, ItalyDepartment of Clinical and Experimental Medicine, Careggi University Hospital, 50134 Florence, ItalyOccupational Medicine, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, ItalyThe objective of the present work was to analyze volatile compounds in alveolar air in patients with squamous cell lung cancer, lung adenocarcinoma or colon cancer, to prepare algorithms able to discriminate such specific pathological conditions. The concentration of 95 volatile compounds was measured in the alveolar air of 45 control subjects, 36 patients with lung adenocarcinoma, 25 patients with squamous cell lung cancer and 52 patients with colon cancer. Volatile compounds were measured with ion molecule reaction mass spectrometry (IMR-MS). An iterated least absolute shrinkage and selection operator multivariate logistic regression model was used to generate specific algorithms and discriminate control subjects from patients with different kinds of cancer. The final predictive models reached the following performance: by using 11 compounds, patients with lung adenocarcinoma were identified with a sensitivity of 86% and specificity of 84%; nine compounds allowed us to identify patients with lung squamous cell carcinoma with a sensitivity of 88% and specificity of 84%; patients with colon adenocarcinoma could be identified with a sensitivity of 96% and a specificity of 73% using a model comprising 13 volatile compounds. The different alveolar profiles of volatile compounds, obtained from patients with three different kinds of cancer, suggest dissimilar biological–biochemistry conditions; each kind of cancer has probably got a specific alveolar profile.https://www.mdpi.com/1420-3049/26/3/550volatile compoundsalveolar airsquamous cell lung cancerlung adenocarcinomacolon cancerion-molecule reaction mass spectrometry (IMR-MS) |
| spellingShingle | Leonardo Politi Lorenzo Monasta Maria Novella Rigressi Andrea Princivalle Alessandro Gonfiotti Gianna Camiciottoli Luigi Perbellini Discriminant Profiles of Volatile Compounds in the Alveolar Air of Patients with Squamous Cell Lung Cancer, Lung Adenocarcinoma or Colon Cancer Molecules volatile compounds alveolar air squamous cell lung cancer lung adenocarcinoma colon cancer ion-molecule reaction mass spectrometry (IMR-MS) |
| title | Discriminant Profiles of Volatile Compounds in the Alveolar Air of Patients with Squamous Cell Lung Cancer, Lung Adenocarcinoma or Colon Cancer |
| title_full | Discriminant Profiles of Volatile Compounds in the Alveolar Air of Patients with Squamous Cell Lung Cancer, Lung Adenocarcinoma or Colon Cancer |
| title_fullStr | Discriminant Profiles of Volatile Compounds in the Alveolar Air of Patients with Squamous Cell Lung Cancer, Lung Adenocarcinoma or Colon Cancer |
| title_full_unstemmed | Discriminant Profiles of Volatile Compounds in the Alveolar Air of Patients with Squamous Cell Lung Cancer, Lung Adenocarcinoma or Colon Cancer |
| title_short | Discriminant Profiles of Volatile Compounds in the Alveolar Air of Patients with Squamous Cell Lung Cancer, Lung Adenocarcinoma or Colon Cancer |
| title_sort | discriminant profiles of volatile compounds in the alveolar air of patients with squamous cell lung cancer lung adenocarcinoma or colon cancer |
| topic | volatile compounds alveolar air squamous cell lung cancer lung adenocarcinoma colon cancer ion-molecule reaction mass spectrometry (IMR-MS) |
| url | https://www.mdpi.com/1420-3049/26/3/550 |
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