Modulation of Insulin Sensitivity by Insulin-Degrading Enzyme

Modulation of Insulin Sensitivity by Insulin-Degrading Enzyme

Insulin-degrading enzyme (IDE) is a highly conserved and ubiquitously expressed metalloprotease that degrades insulin and several other intermediate-size peptides. For many decades, IDE had been assumed to be involved primarily in hepatic insulin clearance, a key process that regulates availability...

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Bibliographic Details
Main Authors: Carlos M. González-Casimiro, Beatriz Merino, Elena Casanueva-Álvarez, Tamara Postigo-Casado, Patricia Cámara-Torres, Cristina M. Fernández-Díaz, Malcolm A. Leissring, Irene Cózar-Castellano, Germán Perdomo
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Biomedicines
Subjects:
insulin-degrading enzyme
insulin resistance
pancreas
liver
insulin receptor
glucose transporters
Online Access:https://www.mdpi.com/2227-9059/9/1/86

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