The practice of fecal microbiota transplantation in inflammatory bowel disease
Current evidence posits a central role for gut microbiota and the metabolome in the pathogenesis and progression of inflammatory bowel disease (IBD). Fecal microbiota transplantation (FMT) has been established as a means to manipulate this microbiome safely and sustainably. Several aspects of the te...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Korean Association for the Study of Intestinal Diseases
2024-01-01
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| Series: | Intestinal Research |
| Subjects: | |
| Online Access: | http://irjournal.org/upload/pdf/ir-2023-00085.pdf |
| _version_ | 1797323656282505216 |
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| author | Umang Arora Saurabh Kedia Vineet Ahuja |
| author_facet | Umang Arora Saurabh Kedia Vineet Ahuja |
| author_sort | Umang Arora |
| collection | DOAJ |
| description | Current evidence posits a central role for gut microbiota and the metabolome in the pathogenesis and progression of inflammatory bowel disease (IBD). Fecal microbiota transplantation (FMT) has been established as a means to manipulate this microbiome safely and sustainably. Several aspects of the technical improvement including pretreatment with antibiotics, use of frozen stool samples as well as short donor-to-recipient time are proposed to improve its response rates. Its efficacy in ulcerative colitis has been proven in clinical trials while data is emerging for Crohn’s disease. This review describes briefly the biology behind FMT, the available evidence for its use in IBD, and the host, recipient and procedural factors which determine the clinical outcomes. |
| first_indexed | 2024-03-08T05:31:44Z |
| format | Article |
| id | doaj.art-2273701a4d0941069e041874f961e139 |
| institution | Directory Open Access Journal |
| issn | 1598-9100 2288-1956 |
| language | English |
| last_indexed | 2024-03-08T05:31:44Z |
| publishDate | 2024-01-01 |
| publisher | Korean Association for the Study of Intestinal Diseases |
| record_format | Article |
| series | Intestinal Research |
| spelling | doaj.art-2273701a4d0941069e041874f961e1392024-02-06T04:27:29ZengKorean Association for the Study of Intestinal DiseasesIntestinal Research1598-91002288-19562024-01-01221446410.5217/ir.2023.000851033The practice of fecal microbiota transplantation in inflammatory bowel diseaseUmang Arora0Saurabh Kedia1Vineet Ahuja Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi, India Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi, IndiaCurrent evidence posits a central role for gut microbiota and the metabolome in the pathogenesis and progression of inflammatory bowel disease (IBD). Fecal microbiota transplantation (FMT) has been established as a means to manipulate this microbiome safely and sustainably. Several aspects of the technical improvement including pretreatment with antibiotics, use of frozen stool samples as well as short donor-to-recipient time are proposed to improve its response rates. Its efficacy in ulcerative colitis has been proven in clinical trials while data is emerging for Crohn’s disease. This review describes briefly the biology behind FMT, the available evidence for its use in IBD, and the host, recipient and procedural factors which determine the clinical outcomes.http://irjournal.org/upload/pdf/ir-2023-00085.pdffecal microbiota transplantationmicrobiotainflammatory bowel diseasesmicrobiome manipulation therapy |
| spellingShingle | Umang Arora Saurabh Kedia Vineet Ahuja The practice of fecal microbiota transplantation in inflammatory bowel disease Intestinal Research fecal microbiota transplantation microbiota inflammatory bowel diseases microbiome manipulation therapy |
| title | The practice of fecal microbiota transplantation in inflammatory bowel disease |
| title_full | The practice of fecal microbiota transplantation in inflammatory bowel disease |
| title_fullStr | The practice of fecal microbiota transplantation in inflammatory bowel disease |
| title_full_unstemmed | The practice of fecal microbiota transplantation in inflammatory bowel disease |
| title_short | The practice of fecal microbiota transplantation in inflammatory bowel disease |
| title_sort | practice of fecal microbiota transplantation in inflammatory bowel disease |
| topic | fecal microbiota transplantation microbiota inflammatory bowel diseases microbiome manipulation therapy |
| url | http://irjournal.org/upload/pdf/ir-2023-00085.pdf |
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