Local chromatin environment of a Polycomb target gene instructs its own epigenetic inheritance
Inheritance of gene expression states is fundamental for cells to ‘remember’ past events, such as environmental or developmental cues. The conserved Polycomb Repressive Complex 2 (PRC2) maintains epigenetic repression of many genes in animals and plants and modifies chromatin at its targets. Histone...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2015-05-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/07205 |
| _version_ | 1811181444019519488 |
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| author | Scott Berry Matthew Hartley Tjelvar S G Olsson Caroline Dean Martin Howard |
| author_facet | Scott Berry Matthew Hartley Tjelvar S G Olsson Caroline Dean Martin Howard |
| author_sort | Scott Berry |
| collection | DOAJ |
| description | Inheritance of gene expression states is fundamental for cells to ‘remember’ past events, such as environmental or developmental cues. The conserved Polycomb Repressive Complex 2 (PRC2) maintains epigenetic repression of many genes in animals and plants and modifies chromatin at its targets. Histones modified by PRC2 can be inherited through cell division. However, it remains unclear whether this inheritance can direct long-term memory of individual gene expression states (cis memory) or instead if local chromatin states are dictated by the concentrations of diffusible factors (trans memory). By monitoring the expression of two copies of the Arabidopsis Polycomb target gene FLOWERING LOCUS C (FLC) in the same plants, we show that one copy can be repressed while the other is active. Furthermore, this ‘mixed’ expression state is inherited through many cell divisions as plants develop. These data demonstrate that epigenetic memory of FLC expression is stored not in trans but in cis. |
| first_indexed | 2024-04-11T09:17:49Z |
| format | Article |
| id | doaj.art-227381fa56a9438b82336adda48e6ad0 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:17:49Z |
| publishDate | 2015-05-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-227381fa56a9438b82336adda48e6ad02022-12-22T04:32:17ZengeLife Sciences Publications LtdeLife2050-084X2015-05-01410.7554/eLife.07205Local chromatin environment of a Polycomb target gene instructs its own epigenetic inheritanceScott Berry0https://orcid.org/0000-0002-1838-4976Matthew Hartley1https://orcid.org/0000-0001-6178-2884Tjelvar S G Olsson2https://orcid.org/0000-0001-8791-4531Caroline Dean3Martin Howard4John Innes Centre, Norwich, United KingdomJohn Innes Centre, Norwich, United KingdomJohn Innes Centre, Norwich, United KingdomJohn Innes Centre, Norwich, United KingdomJohn Innes Centre, Norwich, United KingdomInheritance of gene expression states is fundamental for cells to ‘remember’ past events, such as environmental or developmental cues. The conserved Polycomb Repressive Complex 2 (PRC2) maintains epigenetic repression of many genes in animals and plants and modifies chromatin at its targets. Histones modified by PRC2 can be inherited through cell division. However, it remains unclear whether this inheritance can direct long-term memory of individual gene expression states (cis memory) or instead if local chromatin states are dictated by the concentrations of diffusible factors (trans memory). By monitoring the expression of two copies of the Arabidopsis Polycomb target gene FLOWERING LOCUS C (FLC) in the same plants, we show that one copy can be repressed while the other is active. Furthermore, this ‘mixed’ expression state is inherited through many cell divisions as plants develop. These data demonstrate that epigenetic memory of FLC expression is stored not in trans but in cis.https://elifesciences.org/articles/07205epigeneticcis memoryPolycombFLOWERING LOCUS Cvernalization |
| spellingShingle | Scott Berry Matthew Hartley Tjelvar S G Olsson Caroline Dean Martin Howard Local chromatin environment of a Polycomb target gene instructs its own epigenetic inheritance eLife epigenetic cis memory Polycomb FLOWERING LOCUS C vernalization |
| title | Local chromatin environment of a Polycomb target gene instructs its own epigenetic inheritance |
| title_full | Local chromatin environment of a Polycomb target gene instructs its own epigenetic inheritance |
| title_fullStr | Local chromatin environment of a Polycomb target gene instructs its own epigenetic inheritance |
| title_full_unstemmed | Local chromatin environment of a Polycomb target gene instructs its own epigenetic inheritance |
| title_short | Local chromatin environment of a Polycomb target gene instructs its own epigenetic inheritance |
| title_sort | local chromatin environment of a polycomb target gene instructs its own epigenetic inheritance |
| topic | epigenetic cis memory Polycomb FLOWERING LOCUS C vernalization |
| url | https://elifesciences.org/articles/07205 |
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