| Summary: | Background: One of the most common sites for primary sarcoma is the proximal humerus. Despite several methods of reconstruction, an ideal method for reconstruction after proximal humeral resection is controversial. Reconstructional methods, including endoprosthesis, allograft recycled autograft, and vascularized fibular graft. A total replacement of the humeral bone with allograft following complete resection of a malignant bone tumor has not been reported in the literature. Case report: In this study, we report a case of humerus chondrosarcoma that invaded surrounding soft tissue, which presented with the chief complaint of progressive left arm pain in addition to arm swelling. The left humerus was resected entirely and successfully replaced by a total humerus allograft. Conclusion: Complete replacement of the humerus by an allograft can be one of the treatment choices for this malignancy.
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