Central Precocious Puberty Following Treatment of Precocious Pseudo-Puberty Caused by Leydig Cell Tumor: A Pediatric Case and Literature Review
Leydig cell tumors can cause precocious puberty in prepubertal males. Radical orchiectomy is the standard therapy for Leydig cell tumors, with a good overall prognosis. Here, we present a rare case of secondary central precocious puberty caused by a Leydig cell tumor in a 5 year-old boy. He had an i...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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The Korean Society of Pediatric Hematology-Oncology
2022-10-01
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| Series: | Clinical Pediatric Hematology-Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.15264/cpho.2022.29.2.74 |
| _version_ | 1828338802592055296 |
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| author | Jeong Ho Ahn Ji Kyoung Park Soo Jin Jung Jeong Eun Lee |
| author_facet | Jeong Ho Ahn Ji Kyoung Park Soo Jin Jung Jeong Eun Lee |
| author_sort | Jeong Ho Ahn |
| collection | DOAJ |
| description | Leydig cell tumors can cause precocious puberty in prepubertal males. Radical orchiectomy is the standard therapy for Leydig cell tumors, with a good overall prognosis. Here, we present a rare case of secondary central precocious puberty caused by a Leydig cell tumor in a 5 year-old boy. He had an isosexual precocity and advanced bone age. Laboratory investigations showed high testosterone and low gonadotropin levels, presenting as precocious pseudo-puberty. Seven months after surgical removal of the tumor, the patient was diagnosed with central precocious puberty by GnRH stimulation test. He was initiated on GnRH agonist therapy, which has been administered every 13 weeks to date. Post-surgery surveillance of Leydig cell tumors should include evaluation for progression to secondary central precocious puberty as well as recurrence of Leydig cell tumor or metachronous tumors in prepubertal children. |
| first_indexed | 2024-04-13T22:33:08Z |
| format | Article |
| id | doaj.art-2275f06bac1d48058840fd26d93c00d0 |
| institution | Directory Open Access Journal |
| issn | 2233-5250 |
| language | English |
| last_indexed | 2024-04-13T22:33:08Z |
| publishDate | 2022-10-01 |
| publisher | The Korean Society of Pediatric Hematology-Oncology |
| record_format | Article |
| series | Clinical Pediatric Hematology-Oncology |
| spelling | doaj.art-2275f06bac1d48058840fd26d93c00d02022-12-22T02:26:51ZengThe Korean Society of Pediatric Hematology-OncologyClinical Pediatric Hematology-Oncology2233-52502022-10-01292747810.15264/cpho.2022.29.2.74cpho.2022.29.2.74Central Precocious Puberty Following Treatment of Precocious Pseudo-Puberty Caused by Leydig Cell Tumor: A Pediatric Case and Literature ReviewJeong Ho Ahn0Ji Kyoung Park1Soo Jin Jung2Jeong Eun Lee3Department of Pediatrics, Busan Paik Hospital, Inje University College of Medicine, Busan, KoreaDepartment of Pediatrics, Busan Paik Hospital, Inje University College of Medicine, Busan, KoreaDepartment of Pathology, Busan Paik Hospital, Inje University College of Medicine, Busan, KoreaDepartment of Pediatrics, Busan Paik Hospital, Inje University College of Medicine, Busan, KoreaLeydig cell tumors can cause precocious puberty in prepubertal males. Radical orchiectomy is the standard therapy for Leydig cell tumors, with a good overall prognosis. Here, we present a rare case of secondary central precocious puberty caused by a Leydig cell tumor in a 5 year-old boy. He had an isosexual precocity and advanced bone age. Laboratory investigations showed high testosterone and low gonadotropin levels, presenting as precocious pseudo-puberty. Seven months after surgical removal of the tumor, the patient was diagnosed with central precocious puberty by GnRH stimulation test. He was initiated on GnRH agonist therapy, which has been administered every 13 weeks to date. Post-surgery surveillance of Leydig cell tumors should include evaluation for progression to secondary central precocious puberty as well as recurrence of Leydig cell tumor or metachronous tumors in prepubertal children.https://doi.org/10.15264/cpho.2022.29.2.74leydig cell tumorprecocious pseudo-pubertycentral precocious puberty |
| spellingShingle | Jeong Ho Ahn Ji Kyoung Park Soo Jin Jung Jeong Eun Lee Central Precocious Puberty Following Treatment of Precocious Pseudo-Puberty Caused by Leydig Cell Tumor: A Pediatric Case and Literature Review Clinical Pediatric Hematology-Oncology leydig cell tumor precocious pseudo-puberty central precocious puberty |
| title | Central Precocious Puberty Following Treatment of Precocious Pseudo-Puberty Caused by Leydig Cell Tumor: A Pediatric Case and Literature Review |
| title_full | Central Precocious Puberty Following Treatment of Precocious Pseudo-Puberty Caused by Leydig Cell Tumor: A Pediatric Case and Literature Review |
| title_fullStr | Central Precocious Puberty Following Treatment of Precocious Pseudo-Puberty Caused by Leydig Cell Tumor: A Pediatric Case and Literature Review |
| title_full_unstemmed | Central Precocious Puberty Following Treatment of Precocious Pseudo-Puberty Caused by Leydig Cell Tumor: A Pediatric Case and Literature Review |
| title_short | Central Precocious Puberty Following Treatment of Precocious Pseudo-Puberty Caused by Leydig Cell Tumor: A Pediatric Case and Literature Review |
| title_sort | central precocious puberty following treatment of precocious pseudo puberty caused by leydig cell tumor a pediatric case and literature review |
| topic | leydig cell tumor precocious pseudo-puberty central precocious puberty |
| url | https://doi.org/10.15264/cpho.2022.29.2.74 |
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