Association between Statins Administration and Influenza Susceptibility: A Systematic Review and Meta-Analysis of Longitudinal Studies
Previous studies reported that the association between statins use and influenza infection was contradictory. A systematic review and meta-analysis of longitudinal studies were performed to determine the association between statins use and influenza susceptibility. The literature search was conducte...
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2024-02-01
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Online Access: | https://www.mdpi.com/1999-4915/16/2/278 |
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author | Fan Wu Congcong Wang Shunran Li Ying Ye Mingting Cui Yajie Liu Shiqiang Jiang Jun Qian Jianhui Yuan Yuelong Shu Caijun Sun |
author_facet | Fan Wu Congcong Wang Shunran Li Ying Ye Mingting Cui Yajie Liu Shiqiang Jiang Jun Qian Jianhui Yuan Yuelong Shu Caijun Sun |
author_sort | Fan Wu |
collection | DOAJ |
description | Previous studies reported that the association between statins use and influenza infection was contradictory. A systematic review and meta-analysis of longitudinal studies were performed to determine the association between statins use and influenza susceptibility. The literature search was conducted in PubMed, Embase, and Web of Science, from each database’s inception to 21 May 2023. The fixed effect model and random effects model were used for data synthesis. In our study, a total of 1,472,239 statins users and 1,486,881 statins non-users from five articles were included. The pooled risk ratio (RR) of all included participants was 1.05 (95% CI: 1.03–1.07), and there were still significant differences after adjusting for vaccination status. Of note, RR values in statins users were 1.06 (95% CI: 1.03–1.08) in people aged ≥60 years old and 1.05 (95% CI: 1.03–1.07) in participant groups with a higher proportion of females. Administration of statins might be associated with an increased risk of influenza infection, especially among females and elderly people. For those people using statins, we should pay more attention to surveillance of their health conditions and take measures to prevent influenza infection. |
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institution | Directory Open Access Journal |
issn | 1999-4915 |
language | English |
last_indexed | 2024-03-07T22:09:52Z |
publishDate | 2024-02-01 |
publisher | MDPI AG |
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series | Viruses |
spelling | doaj.art-2278c3d9585a4db485377e115aa100542024-02-23T15:37:41ZengMDPI AGViruses1999-49152024-02-0116227810.3390/v16020278Association between Statins Administration and Influenza Susceptibility: A Systematic Review and Meta-Analysis of Longitudinal StudiesFan Wu0Congcong Wang1Shunran Li2Ying Ye3Mingting Cui4Yajie Liu5Shiqiang Jiang6Jun Qian7Jianhui Yuan8Yuelong Shu9Caijun Sun10School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen 518107, ChinaSchool of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen 518107, ChinaSchool of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen 518107, ChinaSchool of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen 518107, ChinaSchool of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen 518107, ChinaSchool of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen 518107, ChinaNanshan District Center for Disease Control and Prevention, Shenzhen 518000, ChinaSchool of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen 518107, ChinaNanshan District Center for Disease Control and Prevention, Shenzhen 518000, ChinaNHC Key Laboratory of System Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, ChinaSchool of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen 518107, ChinaPrevious studies reported that the association between statins use and influenza infection was contradictory. A systematic review and meta-analysis of longitudinal studies were performed to determine the association between statins use and influenza susceptibility. The literature search was conducted in PubMed, Embase, and Web of Science, from each database’s inception to 21 May 2023. The fixed effect model and random effects model were used for data synthesis. In our study, a total of 1,472,239 statins users and 1,486,881 statins non-users from five articles were included. The pooled risk ratio (RR) of all included participants was 1.05 (95% CI: 1.03–1.07), and there were still significant differences after adjusting for vaccination status. Of note, RR values in statins users were 1.06 (95% CI: 1.03–1.08) in people aged ≥60 years old and 1.05 (95% CI: 1.03–1.07) in participant groups with a higher proportion of females. Administration of statins might be associated with an increased risk of influenza infection, especially among females and elderly people. For those people using statins, we should pay more attention to surveillance of their health conditions and take measures to prevent influenza infection.https://www.mdpi.com/1999-4915/16/2/278statinsinfluenzasusceptibilityinfection risk |
spellingShingle | Fan Wu Congcong Wang Shunran Li Ying Ye Mingting Cui Yajie Liu Shiqiang Jiang Jun Qian Jianhui Yuan Yuelong Shu Caijun Sun Association between Statins Administration and Influenza Susceptibility: A Systematic Review and Meta-Analysis of Longitudinal Studies Viruses statins influenza susceptibility infection risk |
title | Association between Statins Administration and Influenza Susceptibility: A Systematic Review and Meta-Analysis of Longitudinal Studies |
title_full | Association between Statins Administration and Influenza Susceptibility: A Systematic Review and Meta-Analysis of Longitudinal Studies |
title_fullStr | Association between Statins Administration and Influenza Susceptibility: A Systematic Review and Meta-Analysis of Longitudinal Studies |
title_full_unstemmed | Association between Statins Administration and Influenza Susceptibility: A Systematic Review and Meta-Analysis of Longitudinal Studies |
title_short | Association between Statins Administration and Influenza Susceptibility: A Systematic Review and Meta-Analysis of Longitudinal Studies |
title_sort | association between statins administration and influenza susceptibility a systematic review and meta analysis of longitudinal studies |
topic | statins influenza susceptibility infection risk |
url | https://www.mdpi.com/1999-4915/16/2/278 |
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