Oxyresveratrol Ameliorates Dextran Sulfate Sodium-Induced Colitis in Rats by Suppressing Inflammation
Colitis causes destruction of the intestinal mucus layer and increases intestinal inflammation. The use of antioxidants and anti-inflammatory agents derived from natural sources has been recently highlighted as a new approach for the treatment of colitis. Oxyresveratrol (OXY) is an antioxidant known...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-04-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/26/9/2630 |
| _version_ | 1827693612757942272 |
|---|---|
| author | Jiah Yeom Seongho Ma Jeong-Keun Kim Young-Hee Lim |
| author_facet | Jiah Yeom Seongho Ma Jeong-Keun Kim Young-Hee Lim |
| author_sort | Jiah Yeom |
| collection | DOAJ |
| description | Colitis causes destruction of the intestinal mucus layer and increases intestinal inflammation. The use of antioxidants and anti-inflammatory agents derived from natural sources has been recently highlighted as a new approach for the treatment of colitis. Oxyresveratrol (OXY) is an antioxidant known to have various beneficial effects on human health, such as anti-inflammatory, antibacterial activity, and antiviral activity. The aim of this study was to investigate the therapeutic effect of OXY in rats with dextran sulfate sodium (DSS)-induced acute colitis. OXY ameliorated DSS-induced colitis and repaired damaged intestinal mucosa. OXY downregulated the expression of pro-inflammatory cytokine genes (<i>TNF-</i>α, <i>IL-6</i>, and <i>IL-1</i>β) and chemokine gene <i>MCP-1</i>, while promoting the production of anti-inflammatory cytokine IL-10. OXY treatment also suppressed inflammation via inhibiting cyclooxygenase-2 (<i>COX-2</i>) and inducible nitric oxide synthase (<i>iNOS</i>) expression in the colon, as well as the activity of myeloperoxidase (MPO). OXY exhibited anti-apoptotic effects, shifting the Bax/Bcl-2 balance. In conclusion, OXY might improve DSS-induced colitis by restoring the intestinal mucus layer and reducing inflammation within the intestine. |
| first_indexed | 2024-03-10T11:47:55Z |
| format | Article |
| id | doaj.art-22797e8afd4b4b56ad7672f74cde4605 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T11:47:55Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-22797e8afd4b4b56ad7672f74cde46052023-11-21T17:56:53ZengMDPI AGMolecules1420-30492021-04-01269263010.3390/molecules26092630Oxyresveratrol Ameliorates Dextran Sulfate Sodium-Induced Colitis in Rats by Suppressing InflammationJiah Yeom0Seongho Ma1Jeong-Keun Kim2Young-Hee Lim3Department of Integrated Biomedical and Life Sciences, Graduate School, Korea University, Seoul 02841, KoreaDepartment of Integrated Biomedical and Life Sciences, Graduate School, Korea University, Seoul 02841, KoreaDepartment of Chemical Engineering and Biotechnology, Korea Polytechnic University, Shihung-si 15073, Gyeonggi-do, KoreaDepartment of Integrated Biomedical and Life Sciences, Graduate School, Korea University, Seoul 02841, KoreaColitis causes destruction of the intestinal mucus layer and increases intestinal inflammation. The use of antioxidants and anti-inflammatory agents derived from natural sources has been recently highlighted as a new approach for the treatment of colitis. Oxyresveratrol (OXY) is an antioxidant known to have various beneficial effects on human health, such as anti-inflammatory, antibacterial activity, and antiviral activity. The aim of this study was to investigate the therapeutic effect of OXY in rats with dextran sulfate sodium (DSS)-induced acute colitis. OXY ameliorated DSS-induced colitis and repaired damaged intestinal mucosa. OXY downregulated the expression of pro-inflammatory cytokine genes (<i>TNF-</i>α, <i>IL-6</i>, and <i>IL-1</i>β) and chemokine gene <i>MCP-1</i>, while promoting the production of anti-inflammatory cytokine IL-10. OXY treatment also suppressed inflammation via inhibiting cyclooxygenase-2 (<i>COX-2</i>) and inducible nitric oxide synthase (<i>iNOS</i>) expression in the colon, as well as the activity of myeloperoxidase (MPO). OXY exhibited anti-apoptotic effects, shifting the Bax/Bcl-2 balance. In conclusion, OXY might improve DSS-induced colitis by restoring the intestinal mucus layer and reducing inflammation within the intestine.https://www.mdpi.com/1420-3049/26/9/2630oxyresveratrolcolitisanti-inflammatoryintestinal mucus layer |
| spellingShingle | Jiah Yeom Seongho Ma Jeong-Keun Kim Young-Hee Lim Oxyresveratrol Ameliorates Dextran Sulfate Sodium-Induced Colitis in Rats by Suppressing Inflammation Molecules oxyresveratrol colitis anti-inflammatory intestinal mucus layer |
| title | Oxyresveratrol Ameliorates Dextran Sulfate Sodium-Induced Colitis in Rats by Suppressing Inflammation |
| title_full | Oxyresveratrol Ameliorates Dextran Sulfate Sodium-Induced Colitis in Rats by Suppressing Inflammation |
| title_fullStr | Oxyresveratrol Ameliorates Dextran Sulfate Sodium-Induced Colitis in Rats by Suppressing Inflammation |
| title_full_unstemmed | Oxyresveratrol Ameliorates Dextran Sulfate Sodium-Induced Colitis in Rats by Suppressing Inflammation |
| title_short | Oxyresveratrol Ameliorates Dextran Sulfate Sodium-Induced Colitis in Rats by Suppressing Inflammation |
| title_sort | oxyresveratrol ameliorates dextran sulfate sodium induced colitis in rats by suppressing inflammation |
| topic | oxyresveratrol colitis anti-inflammatory intestinal mucus layer |
| url | https://www.mdpi.com/1420-3049/26/9/2630 |
| work_keys_str_mv | AT jiahyeom oxyresveratrolamelioratesdextransulfatesodiuminducedcolitisinratsbysuppressinginflammation AT seonghoma oxyresveratrolamelioratesdextransulfatesodiuminducedcolitisinratsbysuppressinginflammation AT jeongkeunkim oxyresveratrolamelioratesdextransulfatesodiuminducedcolitisinratsbysuppressinginflammation AT youngheelim oxyresveratrolamelioratesdextransulfatesodiuminducedcolitisinratsbysuppressinginflammation |