Biomaterials-based formulations and surfaces to combat viral infectious diseases
Rapidly growing viral infections are potent risks to public health worldwide. Accessible virus-specific antiviral vaccines and drugs are therapeutically inert to emerging viruses, such as Zika, Ebola, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Therefore, discovering ways to pr...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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AIP Publishing LLC
2021-03-01
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| Series: | APL Bioengineering |
| Online Access: | http://dx.doi.org/10.1063/5.0029486 |
| _version_ | 1818644205258407936 |
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| author | Sushma Kumari Kaushik Chatterjee |
| author_facet | Sushma Kumari Kaushik Chatterjee |
| author_sort | Sushma Kumari |
| collection | DOAJ |
| description | Rapidly growing viral infections are potent risks to public health worldwide. Accessible virus-specific antiviral vaccines and drugs are therapeutically inert to emerging viruses, such as Zika, Ebola, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Therefore, discovering ways to prevent and control viral infections is among the foremost medical challenge of our time. Recently, innovative technologies are emerging that involve the development of new biomaterial-based formulations and surfaces endowed with broad-spectrum antiviral properties. Here, we review emerging biomaterials technologies for controlling viral infections. Relevant advances in biomaterials employed with nanotechnology to inactivate viruses or to inhibit virus replication and further their translation in safe and effective antiviral formulations in clinical trials are discussed. We have included antiviral approaches based on both organic and inorganic nanoparticles (NPs), which offer many advantages over molecular medicine. An insight into the development of immunomodulatory scaffolds in designing new platforms for personalized vaccines is also considered. Substantial research on natural products and herbal medicines and their potential in novel antiviral drugs are discussed. Furthermore, to control contagious viral infections, i.e., to reduce the viral load on surfaces, current strategies focusing on biomimetic anti-adhesive surfaces through nanostructured topography and hydrophobic surface modification techniques are introduced. Biomaterial surfaces functionalized with antimicrobial polymers and nanoparticles against viral infections are also discussed. We recognize the importance of research on antiviral biomaterials and present potential strategies for future directions in applying these biomaterial-based approaches to control viral infections and SARS-CoV-2. |
| first_indexed | 2024-12-17T00:11:09Z |
| format | Article |
| id | doaj.art-227c54bc216544b5a8f38edb565a7dbc |
| institution | Directory Open Access Journal |
| issn | 2473-2877 |
| language | English |
| last_indexed | 2024-12-17T00:11:09Z |
| publishDate | 2021-03-01 |
| publisher | AIP Publishing LLC |
| record_format | Article |
| series | APL Bioengineering |
| spelling | doaj.art-227c54bc216544b5a8f38edb565a7dbc2022-12-21T22:10:50ZengAIP Publishing LLCAPL Bioengineering2473-28772021-03-0151011503011503-1410.1063/5.0029486Biomaterials-based formulations and surfaces to combat viral infectious diseasesSushma Kumari0Kaushik Chatterjee1 Department of Materials Engineering, Indian Institute of Science, Bangalore 560012, India Department of Materials Engineering, Indian Institute of Science, Bangalore 560012, India Rapidly growing viral infections are potent risks to public health worldwide. Accessible virus-specific antiviral vaccines and drugs are therapeutically inert to emerging viruses, such as Zika, Ebola, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Therefore, discovering ways to prevent and control viral infections is among the foremost medical challenge of our time. Recently, innovative technologies are emerging that involve the development of new biomaterial-based formulations and surfaces endowed with broad-spectrum antiviral properties. Here, we review emerging biomaterials technologies for controlling viral infections. Relevant advances in biomaterials employed with nanotechnology to inactivate viruses or to inhibit virus replication and further their translation in safe and effective antiviral formulations in clinical trials are discussed. We have included antiviral approaches based on both organic and inorganic nanoparticles (NPs), which offer many advantages over molecular medicine. An insight into the development of immunomodulatory scaffolds in designing new platforms for personalized vaccines is also considered. Substantial research on natural products and herbal medicines and their potential in novel antiviral drugs are discussed. Furthermore, to control contagious viral infections, i.e., to reduce the viral load on surfaces, current strategies focusing on biomimetic anti-adhesive surfaces through nanostructured topography and hydrophobic surface modification techniques are introduced. Biomaterial surfaces functionalized with antimicrobial polymers and nanoparticles against viral infections are also discussed. We recognize the importance of research on antiviral biomaterials and present potential strategies for future directions in applying these biomaterial-based approaches to control viral infections and SARS-CoV-2.http://dx.doi.org/10.1063/5.0029486 |
| spellingShingle | Sushma Kumari Kaushik Chatterjee Biomaterials-based formulations and surfaces to combat viral infectious diseases APL Bioengineering |
| title | Biomaterials-based formulations and surfaces to combat viral infectious diseases |
| title_full | Biomaterials-based formulations and surfaces to combat viral infectious diseases |
| title_fullStr | Biomaterials-based formulations and surfaces to combat viral infectious diseases |
| title_full_unstemmed | Biomaterials-based formulations and surfaces to combat viral infectious diseases |
| title_short | Biomaterials-based formulations and surfaces to combat viral infectious diseases |
| title_sort | biomaterials based formulations and surfaces to combat viral infectious diseases |
| url | http://dx.doi.org/10.1063/5.0029486 |
| work_keys_str_mv | AT sushmakumari biomaterialsbasedformulationsandsurfacestocombatviralinfectiousdiseases AT kaushikchatterjee biomaterialsbasedformulationsandsurfacestocombatviralinfectiousdiseases |