Prophylactic Versus Therapeutic Antibiotic Therapy Following Appendicectomy
Background: In the first 4 hours after a breach in an epithelial surface and underlying connective tissues made during surgery or trauma, there is a delay before host defences can become mobilised through acute inflammatory, humeral and cellular processes. This period is called the ‘decisive p...
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| Format: | Article |
| Language: | English |
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College of medicine/ University of Diyala
2018-08-01
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| Series: | Diyala Journal of Medicine |
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| Online Access: | http://djm.uodiyala.edu.iq/index.php/djm/article/view/94 |
| _version_ | 1797454748350152704 |
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| author | Muqdad Fuad Abdulkareem Humamalddin Edan Hussein |
| author_facet | Muqdad Fuad Abdulkareem Humamalddin Edan Hussein |
| author_sort | Muqdad Fuad Abdulkareem |
| collection | DOAJ |
| description |
Background: In the first 4 hours after a breach in an epithelial surface and underlying connective tissues made during surgery or trauma, there is a delay before host defences can become mobilised through acute inflammatory, humeral and cellular processes. This period is called the ‘decisive period’ and it is during these first 4 hours after incision that bacterial colonisation and established infection can begin. It is logical that prophylactic antibiotics will be most effective during this time. Following closure of the wound, local intravascular coagulation and the events of early inflammation that initiate wound healing seal its environment: this may explain why the postoperative administration of antibiotics is ineffective in preventing wound infection.
Objective: To investigate the benefit of prolonged antibiotic therapy following appendicectomy of uncomplicated appendicitis in preventing surgical site infection. Patients and Methods: Two hundred patients who undergone appendicectomy had been reviewed prospectively over a period of one year and eight months (January 2009-Augest 2010) in the surgical ward in Baquba teaching hospital, reviewed for the need for prolonged antibiotic therapy in decreasing the incidence of surgical site infection. All of the patients have uncomplicated appendicitis (non-perforated) .The patients are divided into two groups. In group 1 the patients given single dose of antibiotic (Cefazolin) at the time of induction of anesthesia and only two doses postoperatively. In group 2, the patients did not receive preoperative antibiotic but given prolonged antibiotic cover first parenteral then enteral till the time of removal of stitches. The two groups are examined for the development of surgical site infection.
Results: No significant difference in the incidence of occurrence of surgical site infection between the two groups.
Conclusion: Prolonged postoperative antibiotic therapy is of no value in preventing surgical site infection in patient underwent appendicectomy for uncomplicated appendicitis.
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| first_indexed | 2024-03-09T15:41:34Z |
| format | Article |
| id | doaj.art-227c6dc88c574715ab506f9cf4a866a8 |
| institution | Directory Open Access Journal |
| issn | 2219-9764 2617-8982 |
| language | English |
| last_indexed | 2024-03-09T15:41:34Z |
| publishDate | 2018-08-01 |
| publisher | College of medicine/ University of Diyala |
| record_format | Article |
| series | Diyala Journal of Medicine |
| spelling | doaj.art-227c6dc88c574715ab506f9cf4a866a82023-11-24T23:24:53ZengCollege of medicine/ University of DiyalaDiyala Journal of Medicine2219-97642617-89822018-08-01132Prophylactic Versus Therapeutic Antibiotic Therapy Following AppendicectomyMuqdad Fuad AbdulkareemHumamalddin Edan Hussein Background: In the first 4 hours after a breach in an epithelial surface and underlying connective tissues made during surgery or trauma, there is a delay before host defences can become mobilised through acute inflammatory, humeral and cellular processes. This period is called the ‘decisive period’ and it is during these first 4 hours after incision that bacterial colonisation and established infection can begin. It is logical that prophylactic antibiotics will be most effective during this time. Following closure of the wound, local intravascular coagulation and the events of early inflammation that initiate wound healing seal its environment: this may explain why the postoperative administration of antibiotics is ineffective in preventing wound infection. Objective: To investigate the benefit of prolonged antibiotic therapy following appendicectomy of uncomplicated appendicitis in preventing surgical site infection. Patients and Methods: Two hundred patients who undergone appendicectomy had been reviewed prospectively over a period of one year and eight months (January 2009-Augest 2010) in the surgical ward in Baquba teaching hospital, reviewed for the need for prolonged antibiotic therapy in decreasing the incidence of surgical site infection. All of the patients have uncomplicated appendicitis (non-perforated) .The patients are divided into two groups. In group 1 the patients given single dose of antibiotic (Cefazolin) at the time of induction of anesthesia and only two doses postoperatively. In group 2, the patients did not receive preoperative antibiotic but given prolonged antibiotic cover first parenteral then enteral till the time of removal of stitches. The two groups are examined for the development of surgical site infection. Results: No significant difference in the incidence of occurrence of surgical site infection between the two groups. Conclusion: Prolonged postoperative antibiotic therapy is of no value in preventing surgical site infection in patient underwent appendicectomy for uncomplicated appendicitis. http://djm.uodiyala.edu.iq/index.php/djm/article/view/94Appendicitis, Surgical site infection |
| spellingShingle | Muqdad Fuad Abdulkareem Humamalddin Edan Hussein Prophylactic Versus Therapeutic Antibiotic Therapy Following Appendicectomy Diyala Journal of Medicine Appendicitis, Surgical site infection |
| title | Prophylactic Versus Therapeutic Antibiotic Therapy Following Appendicectomy |
| title_full | Prophylactic Versus Therapeutic Antibiotic Therapy Following Appendicectomy |
| title_fullStr | Prophylactic Versus Therapeutic Antibiotic Therapy Following Appendicectomy |
| title_full_unstemmed | Prophylactic Versus Therapeutic Antibiotic Therapy Following Appendicectomy |
| title_short | Prophylactic Versus Therapeutic Antibiotic Therapy Following Appendicectomy |
| title_sort | prophylactic versus therapeutic antibiotic therapy following appendicectomy |
| topic | Appendicitis, Surgical site infection |
| url | http://djm.uodiyala.edu.iq/index.php/djm/article/view/94 |
| work_keys_str_mv | AT muqdadfuadabdulkareem prophylacticversustherapeuticantibiotictherapyfollowingappendicectomy AT humamalddinedanhussein prophylacticversustherapeuticantibiotictherapyfollowingappendicectomy |