Linear-g-hyperbranched and cyclodextrin-based amphiphilic block copolymer as a multifunctional nanocarrier
In this paper, a novel, multifunctional polymer nanocarrier was designed to provide adequate volume for high drug loading, to afford a multiregion encapsulation ability, and to achieve controlled drug release. An amphiphilic, triblock polymer (ABC) with hyperbranched polycarbonsilane (HBPCSi) and β-...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2014-11-01
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| Series: | Beilstein Journal of Organic Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjoc.10.284 |
| _version_ | 1818733579690049536 |
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| author | Yamei Zhao Wei Tian Guang Yang Xiaodong Fan |
| author_facet | Yamei Zhao Wei Tian Guang Yang Xiaodong Fan |
| author_sort | Yamei Zhao |
| collection | DOAJ |
| description | In this paper, a novel, multifunctional polymer nanocarrier was designed to provide adequate volume for high drug loading, to afford a multiregion encapsulation ability, and to achieve controlled drug release. An amphiphilic, triblock polymer (ABC) with hyperbranched polycarbonsilane (HBPCSi) and β-cyclodextrin (β-CD) moieties were first synthesized by the combination of a two-step reversible addition-fragmentation transfer polymerization into a pseudo-one-step hydrosilylation and quaternization reaction. The ABC then self-assembled into stable micelles with a core–shell structure in aqueous solution. These resulting micelles are multifunctional nanocarriers which possess higher drug loading capability due to the introduction of HBPCSi segments and β-CD moieties, and exhibit controlled drug release based on the diffusion release mechanism. The novel multifunctional nanocarrier may be applicable to produce highly efficient and specialized delivery systems for drugs, genes, and diagnostic agents. |
| first_indexed | 2024-12-17T23:51:43Z |
| format | Article |
| id | doaj.art-227cde1210fd4740ac45dc6d932af0a9 |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-12-17T23:51:43Z |
| publishDate | 2014-11-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-227cde1210fd4740ac45dc6d932af0a92022-12-21T21:28:11ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972014-11-011012696270310.3762/bjoc.10.2841860-5397-10-284Linear-g-hyperbranched and cyclodextrin-based amphiphilic block copolymer as a multifunctional nanocarrierYamei Zhao0Wei Tian1Guang Yang2Xiaodong Fan3College of Environmental and Chemical Engineering, Xi’an Polytechnic University, Xi’an, 710048, P. R. China,The Key Laboratory of Space Applied Physics and Chemistry, Ministry of Education and Shanxi Key Laboratory of Macromolecular Science and Technology, School of Science, Northwestern Polytechnical University, Xi’an, 710072, P. R. ChinaThe Key Laboratory of Space Applied Physics and Chemistry, Ministry of Education and Shanxi Key Laboratory of Macromolecular Science and Technology, School of Science, Northwestern Polytechnical University, Xi’an, 710072, P. R. ChinaThe Key Laboratory of Space Applied Physics and Chemistry, Ministry of Education and Shanxi Key Laboratory of Macromolecular Science and Technology, School of Science, Northwestern Polytechnical University, Xi’an, 710072, P. R. ChinaIn this paper, a novel, multifunctional polymer nanocarrier was designed to provide adequate volume for high drug loading, to afford a multiregion encapsulation ability, and to achieve controlled drug release. An amphiphilic, triblock polymer (ABC) with hyperbranched polycarbonsilane (HBPCSi) and β-cyclodextrin (β-CD) moieties were first synthesized by the combination of a two-step reversible addition-fragmentation transfer polymerization into a pseudo-one-step hydrosilylation and quaternization reaction. The ABC then self-assembled into stable micelles with a core–shell structure in aqueous solution. These resulting micelles are multifunctional nanocarriers which possess higher drug loading capability due to the introduction of HBPCSi segments and β-CD moieties, and exhibit controlled drug release based on the diffusion release mechanism. The novel multifunctional nanocarrier may be applicable to produce highly efficient and specialized delivery systems for drugs, genes, and diagnostic agents.https://doi.org/10.3762/bjoc.10.284amphiphilic block copolymercyclodextrin polymerhyperbranched polymermultifunctionalitypolymer nanocarrier |
| spellingShingle | Yamei Zhao Wei Tian Guang Yang Xiaodong Fan Linear-g-hyperbranched and cyclodextrin-based amphiphilic block copolymer as a multifunctional nanocarrier Beilstein Journal of Organic Chemistry amphiphilic block copolymer cyclodextrin polymer hyperbranched polymer multifunctionality polymer nanocarrier |
| title | Linear-g-hyperbranched and cyclodextrin-based amphiphilic block copolymer as a multifunctional nanocarrier |
| title_full | Linear-g-hyperbranched and cyclodextrin-based amphiphilic block copolymer as a multifunctional nanocarrier |
| title_fullStr | Linear-g-hyperbranched and cyclodextrin-based amphiphilic block copolymer as a multifunctional nanocarrier |
| title_full_unstemmed | Linear-g-hyperbranched and cyclodextrin-based amphiphilic block copolymer as a multifunctional nanocarrier |
| title_short | Linear-g-hyperbranched and cyclodextrin-based amphiphilic block copolymer as a multifunctional nanocarrier |
| title_sort | linear g hyperbranched and cyclodextrin based amphiphilic block copolymer as a multifunctional nanocarrier |
| topic | amphiphilic block copolymer cyclodextrin polymer hyperbranched polymer multifunctionality polymer nanocarrier |
| url | https://doi.org/10.3762/bjoc.10.284 |
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