The research development of STAT3 in hepatic ischemia-reperfusion injury
Ischemia-reperfusion injury (IRI) is a common complication of surgery, which can cause rapid deterioration of the liver function, increase the risk of graft rejection, and seriously affect the prognosis of patients. The signal transducer and activator of transcription 3 (STAT3) protein has been impl...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2023-01-01
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Series: | Frontiers in Immunology |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1066222/full |
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author | Hanwen Yang Pengpeng Zhang Qiang Wang Ke Cheng Yujun Zhao |
author_facet | Hanwen Yang Pengpeng Zhang Qiang Wang Ke Cheng Yujun Zhao |
author_sort | Hanwen Yang |
collection | DOAJ |
description | Ischemia-reperfusion injury (IRI) is a common complication of surgery, which can cause rapid deterioration of the liver function, increase the risk of graft rejection, and seriously affect the prognosis of patients. The signal transducer and activator of transcription 3 (STAT3) protein has been implicated in pathogenesis of IRI. STAT3 influences the mitochondria through multiple pathways and is also involved in apoptosis and other forms of programmed cell death. STAT3 is associated with Janus kinase (JAK), phosphoinositide-3 kinase (PI3K), and heme oxygenase-1 (HO-1) in liver IRI. The STAT3 pathway plays a dual role in IRI as it can also regulate lipid metabolism which may have potential for treating IRI fatty liver. In this review, we summarize research on the function of STAT3 in liver IRI to provide references for its application in the clinic. |
first_indexed | 2024-04-10T20:46:38Z |
format | Article |
id | doaj.art-228042db91e94570be986cbd4412ded9 |
institution | Directory Open Access Journal |
issn | 1664-3224 |
language | English |
last_indexed | 2024-04-10T20:46:38Z |
publishDate | 2023-01-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Immunology |
spelling | doaj.art-228042db91e94570be986cbd4412ded92023-01-24T07:02:58ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-01-011410.3389/fimmu.2023.10662221066222The research development of STAT3 in hepatic ischemia-reperfusion injuryHanwen YangPengpeng ZhangQiang WangKe ChengYujun ZhaoIschemia-reperfusion injury (IRI) is a common complication of surgery, which can cause rapid deterioration of the liver function, increase the risk of graft rejection, and seriously affect the prognosis of patients. The signal transducer and activator of transcription 3 (STAT3) protein has been implicated in pathogenesis of IRI. STAT3 influences the mitochondria through multiple pathways and is also involved in apoptosis and other forms of programmed cell death. STAT3 is associated with Janus kinase (JAK), phosphoinositide-3 kinase (PI3K), and heme oxygenase-1 (HO-1) in liver IRI. The STAT3 pathway plays a dual role in IRI as it can also regulate lipid metabolism which may have potential for treating IRI fatty liver. In this review, we summarize research on the function of STAT3 in liver IRI to provide references for its application in the clinic.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1066222/fullsignal transducers and activators of transcription3 (STAT3)ischemia-reperfusion injury (IRI)mitochondriacell apoptosisliver |
spellingShingle | Hanwen Yang Pengpeng Zhang Qiang Wang Ke Cheng Yujun Zhao The research development of STAT3 in hepatic ischemia-reperfusion injury Frontiers in Immunology signal transducers and activators of transcription3 (STAT3) ischemia-reperfusion injury (IRI) mitochondria cell apoptosis liver |
title | The research development of STAT3 in hepatic ischemia-reperfusion injury |
title_full | The research development of STAT3 in hepatic ischemia-reperfusion injury |
title_fullStr | The research development of STAT3 in hepatic ischemia-reperfusion injury |
title_full_unstemmed | The research development of STAT3 in hepatic ischemia-reperfusion injury |
title_short | The research development of STAT3 in hepatic ischemia-reperfusion injury |
title_sort | research development of stat3 in hepatic ischemia reperfusion injury |
topic | signal transducers and activators of transcription3 (STAT3) ischemia-reperfusion injury (IRI) mitochondria cell apoptosis liver |
url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1066222/full |
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