Drugs and clinical trials in neurodegenerative diseases
Neurodegenerative diseases are disabling conditions continuously increasing due to aging of population. A disease modifying therapy that slows or stops disease progression is therefore a major unmet medical need. Unfortunately, research for effective treatments is hampered by lack of knowledge on th...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Istituto Superiore di Sanità
2011-01-01
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| Series: | Annali dell'Istituto Superiore di Sanità |
| Subjects: | |
| Online Access: | http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0021-25712011000100011&lng=en&tlng=en |
| _version_ | 1819296310055927808 |
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| author | Paolo Stanzione Domenicantonio Tropepi |
| author_facet | Paolo Stanzione Domenicantonio Tropepi |
| author_sort | Paolo Stanzione |
| collection | DOAJ |
| description | Neurodegenerative diseases are disabling conditions continuously increasing due to aging of population. A disease modifying therapy that slows or stops disease progression is therefore a major unmet medical need. Unfortunately, research for effective treatments is hampered by lack of knowledge on the pathologic processes underpinning these diseases and of reliable biomarkers. Clinical trials are difficult, as they require large populations that need to be followed for very long periods to capture possible effects on disease progression. These difficulties produce frequent failures and waste of human and economic resources. Since research has to continue in this area, until comprehensive knowledge of basic pathologic processes is obtained, alternative study designs can be considered to identify disease modifiers and to reduce costs of clinical studies. |
| first_indexed | 2024-12-24T04:56:04Z |
| format | Article |
| id | doaj.art-22812d8f640546f2815666720e08b58b |
| institution | Directory Open Access Journal |
| issn | 0021-2571 |
| language | English |
| last_indexed | 2024-12-24T04:56:04Z |
| publishDate | 2011-01-01 |
| publisher | Istituto Superiore di Sanità |
| record_format | Article |
| series | Annali dell'Istituto Superiore di Sanità |
| spelling | doaj.art-22812d8f640546f2815666720e08b58b2022-12-21T17:14:23ZengIstituto Superiore di SanitàAnnali dell'Istituto Superiore di Sanità0021-25712011-01-01471495410.4415/ANN_11_01_11S0021-25712011000100011Drugs and clinical trials in neurodegenerative diseasesPaolo Stanzione0Domenicantonio Tropepi1Università degli Studi Tor VergataIRCCS Fondazione S. LuciaNeurodegenerative diseases are disabling conditions continuously increasing due to aging of population. A disease modifying therapy that slows or stops disease progression is therefore a major unmet medical need. Unfortunately, research for effective treatments is hampered by lack of knowledge on the pathologic processes underpinning these diseases and of reliable biomarkers. Clinical trials are difficult, as they require large populations that need to be followed for very long periods to capture possible effects on disease progression. These difficulties produce frequent failures and waste of human and economic resources. Since research has to continue in this area, until comprehensive knowledge of basic pathologic processes is obtained, alternative study designs can be considered to identify disease modifiers and to reduce costs of clinical studies.http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0021-25712011000100011&lng=en&tlng=enmalattie neurodegenerativedisease modifierdelayed start designrandomized withdrawal designstudio di futilità |
| spellingShingle | Paolo Stanzione Domenicantonio Tropepi Drugs and clinical trials in neurodegenerative diseases Annali dell'Istituto Superiore di Sanità malattie neurodegenerative disease modifier delayed start design randomized withdrawal design studio di futilità |
| title | Drugs and clinical trials in neurodegenerative diseases |
| title_full | Drugs and clinical trials in neurodegenerative diseases |
| title_fullStr | Drugs and clinical trials in neurodegenerative diseases |
| title_full_unstemmed | Drugs and clinical trials in neurodegenerative diseases |
| title_short | Drugs and clinical trials in neurodegenerative diseases |
| title_sort | drugs and clinical trials in neurodegenerative diseases |
| topic | malattie neurodegenerative disease modifier delayed start design randomized withdrawal design studio di futilità |
| url | http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0021-25712011000100011&lng=en&tlng=en |
| work_keys_str_mv | AT paolostanzione drugsandclinicaltrialsinneurodegenerativediseases AT domenicantoniotropepi drugsandclinicaltrialsinneurodegenerativediseases |