Potentially Inappropriate Medication Among People With Dementia in China: A Nationwide Cross-Sectional Study
Objectives: The purpose of this study was to explore the prevalence of potentially inappropriate medication (PIM) among older outpatients (age ≥ 65 years old) with dementia in eight cities in China using the AGS Beers criteria of 2019 and to identify the potential factor increasing the number of PIM...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.929584/full |
| _version_ | 1828554712427790336 |
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| author | Mengnan Zhao Mengnan Zhao Zhaoyan Chen Fangyuan Tian Ting Xu Ting Xu |
| author_facet | Mengnan Zhao Mengnan Zhao Zhaoyan Chen Fangyuan Tian Ting Xu Ting Xu |
| author_sort | Mengnan Zhao |
| collection | DOAJ |
| description | Objectives: The purpose of this study was to explore the prevalence of potentially inappropriate medication (PIM) among older outpatients (age ≥ 65 years old) with dementia in eight cities in China using the AGS Beers criteria of 2019 and to identify the potential factor increasing the number of PIMs.Methods: A cross-sectional study about PIM in older outpatients with dementia from January 2020 to December 2020 was carried out in eight cities in China, Chengdu, Beijing, Guangzhou, Shanghai, Shenyang, Tianjin, Zhengzhou, and Hangzhou, distributing five major geographical regions in China (east, west, north, south, central). The diagnosis of dementia was based on the International Classification of Diseases (ICD-10) to identify. Based on the 2019 AGS Beers criteria, the PIM prescriptions were evaluated. The identification of potential factors was completed using a binary logistic regression model.Results: Of 18,624 older outpatients with dementia, 3.52% were detected with 1 PIM, and 35.91% received at least two PIMs. The antipsychotic drugs quetiapine and olanzapine were most frequently prescribed in patients with PIM, accounting for 8.01 and 7.36%, respectively. Logistic regression analyses showed that female patients with dementia aged >80 years who took more medications were exposed easily to PIM use.Conclusion: PIM use among older outpatients with dementia in China is highly prevalent, and the associated risk factors were increasing age, female sex, and number of medications. The most frequently prescribed drugs by clinicians were anpsychotropic drugs, which were much more frequent than other drugs. |
| first_indexed | 2024-12-12T05:40:37Z |
| format | Article |
| id | doaj.art-2281327b84de4d39bc9077d98f1b74f7 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-12T05:40:37Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-2281327b84de4d39bc9077d98f1b74f72022-12-22T00:35:55ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-06-011310.3389/fphar.2022.929584929584Potentially Inappropriate Medication Among People With Dementia in China: A Nationwide Cross-Sectional StudyMengnan Zhao0Mengnan Zhao1Zhaoyan Chen2Fangyuan Tian3Ting Xu4Ting Xu5Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, ChinaWest China School of Medicine, Sichuan University, Chengdu, ChinaDepartment of Pharmacy, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Pharmacy, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Pharmacy, West China Hospital, Sichuan University, Chengdu, ChinaWest China School of Medicine, Sichuan University, Chengdu, ChinaObjectives: The purpose of this study was to explore the prevalence of potentially inappropriate medication (PIM) among older outpatients (age ≥ 65 years old) with dementia in eight cities in China using the AGS Beers criteria of 2019 and to identify the potential factor increasing the number of PIMs.Methods: A cross-sectional study about PIM in older outpatients with dementia from January 2020 to December 2020 was carried out in eight cities in China, Chengdu, Beijing, Guangzhou, Shanghai, Shenyang, Tianjin, Zhengzhou, and Hangzhou, distributing five major geographical regions in China (east, west, north, south, central). The diagnosis of dementia was based on the International Classification of Diseases (ICD-10) to identify. Based on the 2019 AGS Beers criteria, the PIM prescriptions were evaluated. The identification of potential factors was completed using a binary logistic regression model.Results: Of 18,624 older outpatients with dementia, 3.52% were detected with 1 PIM, and 35.91% received at least two PIMs. The antipsychotic drugs quetiapine and olanzapine were most frequently prescribed in patients with PIM, accounting for 8.01 and 7.36%, respectively. Logistic regression analyses showed that female patients with dementia aged >80 years who took more medications were exposed easily to PIM use.Conclusion: PIM use among older outpatients with dementia in China is highly prevalent, and the associated risk factors were increasing age, female sex, and number of medications. The most frequently prescribed drugs by clinicians were anpsychotropic drugs, which were much more frequent than other drugs.https://www.frontiersin.org/articles/10.3389/fphar.2022.929584/fullpotentially inappropriate medicationsdementiaoutpatientolderpsychotropic drugs |
| spellingShingle | Mengnan Zhao Mengnan Zhao Zhaoyan Chen Fangyuan Tian Ting Xu Ting Xu Potentially Inappropriate Medication Among People With Dementia in China: A Nationwide Cross-Sectional Study Frontiers in Pharmacology potentially inappropriate medications dementia outpatient older psychotropic drugs |
| title | Potentially Inappropriate Medication Among People With Dementia in China: A Nationwide Cross-Sectional Study |
| title_full | Potentially Inappropriate Medication Among People With Dementia in China: A Nationwide Cross-Sectional Study |
| title_fullStr | Potentially Inappropriate Medication Among People With Dementia in China: A Nationwide Cross-Sectional Study |
| title_full_unstemmed | Potentially Inappropriate Medication Among People With Dementia in China: A Nationwide Cross-Sectional Study |
| title_short | Potentially Inappropriate Medication Among People With Dementia in China: A Nationwide Cross-Sectional Study |
| title_sort | potentially inappropriate medication among people with dementia in china a nationwide cross sectional study |
| topic | potentially inappropriate medications dementia outpatient older psychotropic drugs |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.929584/full |
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