Serum nesfatin in overweight and obese children
BACKGROUND: Obesity is one of the most common children diseases. In present time it is being actively studied the natural hormones role in the pathogenesis of obesity. AIMS: To determine the relationship between serum nesfatin level with impaired lipid metabolism in school age children with overweig...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2020-09-01
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| Series: | Ожирение и метаболизм |
| Subjects: | |
| Online Access: | https://www.omet-endojournals.ru/jour/article/view/12075 |
| _version_ | 1827121693139664896 |
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| author | Vladimir V. Bazarnyi Elena V. Anufrieva Arina Yu. Maksimova Larisa G. Polushina Olga P. Kovtun |
| author_facet | Vladimir V. Bazarnyi Elena V. Anufrieva Arina Yu. Maksimova Larisa G. Polushina Olga P. Kovtun |
| author_sort | Vladimir V. Bazarnyi |
| collection | DOAJ |
| description | BACKGROUND: Obesity is one of the most common children diseases. In present time it is being actively studied the natural hormones role in the pathogenesis of obesity. AIMS: To determine the relationship between serum nesfatin level with impaired lipid metabolism in school age children with overweight and obesity. MATERIALS AND METHODS: The study included children with overweight and obesity («case») and healthy children with normal body mass («control») aged 9 to 15 years. All children were determined by concentration in cholesterol blood and its factions, apoA-1, apoB. Enzyme-linked immunosorbent assay (Bio Human Nesfatin Enzyme Immunoassay Kit). RESULTS: Groups of patients with overweight and obesity (n = 53) and healthy children (n = 31) were comparable by age and sex. In obese children, a significant decrease in the level of nesfatin-1 was revealed compared with the group with normal body weight. In cases of children obesity there is a marked decrease in the concentration of nesfatin-1 in serum, especially expressed in the dyslipidemia presence. The nesfatin-1 level are negatively correlated to BMI and body fat content. CONCLUSIONS: The obtained data suggest that along with the known key role of nesfatin in the regulation of eating behavior and appetite, it also affects anthropometric indicators, primarily associated with the accumulation of excess fat mass. Based on the data obtained, nesfatin-1 should be considered as a possible marker for the development of obesity in children. |
| first_indexed | 2024-03-08T09:12:57Z |
| format | Article |
| id | doaj.art-2284c49418e6491ea307f9688cd71406 |
| institution | Directory Open Access Journal |
| issn | 2071-8713 2306-5524 |
| language | English |
| last_indexed | 2025-03-20T13:57:11Z |
| publishDate | 2020-09-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Ожирение и метаболизм |
| spelling | doaj.art-2284c49418e6491ea307f9688cd714062024-09-11T16:17:52ZengEndocrinology Research CentreОжирение и метаболизм2071-87132306-55242020-09-0117220020710.14341/omet1207510752Serum nesfatin in overweight and obese childrenVladimir V. Bazarnyi0Elena V. Anufrieva1Arina Yu. Maksimova2Larisa G. Polushina3Olga P. Kovtun4Ural State Medical UniversityUral State Medical UniversityUral State Medical UniversityUral State Medical UniversityUral State Medical UniversityBACKGROUND: Obesity is one of the most common children diseases. In present time it is being actively studied the natural hormones role in the pathogenesis of obesity. AIMS: To determine the relationship between serum nesfatin level with impaired lipid metabolism in school age children with overweight and obesity. MATERIALS AND METHODS: The study included children with overweight and obesity («case») and healthy children with normal body mass («control») aged 9 to 15 years. All children were determined by concentration in cholesterol blood and its factions, apoA-1, apoB. Enzyme-linked immunosorbent assay (Bio Human Nesfatin Enzyme Immunoassay Kit). RESULTS: Groups of patients with overweight and obesity (n = 53) and healthy children (n = 31) were comparable by age and sex. In obese children, a significant decrease in the level of nesfatin-1 was revealed compared with the group with normal body weight. In cases of children obesity there is a marked decrease in the concentration of nesfatin-1 in serum, especially expressed in the dyslipidemia presence. The nesfatin-1 level are negatively correlated to BMI and body fat content. CONCLUSIONS: The obtained data suggest that along with the known key role of nesfatin in the regulation of eating behavior and appetite, it also affects anthropometric indicators, primarily associated with the accumulation of excess fat mass. Based on the data obtained, nesfatin-1 should be considered as a possible marker for the development of obesity in children.https://www.omet-endojournals.ru/jour/article/view/12075nesfatin-1childcholesteroloverweightobesity |
| spellingShingle | Vladimir V. Bazarnyi Elena V. Anufrieva Arina Yu. Maksimova Larisa G. Polushina Olga P. Kovtun Serum nesfatin in overweight and obese children Ожирение и метаболизм nesfatin-1 child cholesterol overweight obesity |
| title | Serum nesfatin in overweight and obese children |
| title_full | Serum nesfatin in overweight and obese children |
| title_fullStr | Serum nesfatin in overweight and obese children |
| title_full_unstemmed | Serum nesfatin in overweight and obese children |
| title_short | Serum nesfatin in overweight and obese children |
| title_sort | serum nesfatin in overweight and obese children |
| topic | nesfatin-1 child cholesterol overweight obesity |
| url | https://www.omet-endojournals.ru/jour/article/view/12075 |
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